Oxidized low-density lipoprotein suppresses expression of prostaglandin E receptor subtype EP3 in human THP-1 macrophages

EP3, one of four prostaglandin E2 (PGE2) receptors, is significantly lower in atherosclerotic plaques than in normal arteries and is localized predominantly in macrophages of the plaque shoulder region. However, mechanisms behind this EP3 expression pattern are still unknown. We investigated the und...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110828
Hauptverfasser:	Sui, Xuxia, Liu, Yanmin, Li, Qi, Liu, Gefei, Song, Xuhong, Su, Zhongjing, Chang, Xiaolan, Zhou, Yingbi, Liang, Bin, Huang, Dongyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Arteries Arteriosclerosis Atherosclerosis Cancer Cell activation Cell culture Cell Differentiation - drug effects Cell Line Chromatin Down-regulation Gene expression Gene Expression Regulation - drug effects Genomics Higher education Humans Immunoprecipitation Inflammation Inhibition Kinases Laboratories Leukemia Lipoproteins, LDL - administration & dosage Lipoproteins, LDL - metabolism Low density lipoprotein Low density lipoproteins Macrophages Macrophages - drug effects Macrophages - metabolism Medicine and Health Sciences Molecular biology NF-kappa B - biosynthesis NF-κB protein Penicillin Peroxisome proliferator-activated receptors Phorbol 12-myristate 13-acetate Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Plaques PPAR gamma - biosynthesis PPAR gamma - genetics Prostaglandin E Prostaglandin E2 Prostaglandins E Proteins Receptors Receptors, Prostaglandin E, EP3 Subtype - biosynthesis Receptors, Prostaglandin E, EP3 Subtype - genetics RNA RNA, Messenger - biosynthesis Tetradecanoylphorbol Acetate - administration & dosage Tetradecanoylphorbol Acetate - analogs & derivatives
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