Mechanisms underlying cancer growth and apoptosis by DEK overexpression in colorectal cancer

Our previous study indicated that DEK protein was overexpressed in colorectal carcinoma (CRC) compared with the normal colorectal mucosa. DEK was also significantly correlated with the prognostic characteristics of patients with CRC, demonstrating that DEK played an important role in CRC progression...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e111260-e111260
Hauptverfasser:	Lin, Lijuan, Piao, Junjie, Ma, Yibing, Jin, Tiefeng, Quan, Chengshi, Kong, Jienan, Li, Yulin, Lin, Zhenhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bcl-2 protein Biological effects Biomarkers Cancer Cancer therapies Caspase Cell cycle Cell Line, Tumor Cell Proliferation Chemotherapy Chromosomal Proteins, Non-Histone - metabolism Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - enzymology Colorectal Neoplasms - pathology DEK protein Disease Progression Gene Expression Profiling Growth HCT116 Cells Health aspects Humans Immunohistochemistry Intestinal Mucosa - pathology Ki-67 Antigen - metabolism Laboratories Leukemia Medical prognosis Medical research Medicine and Health Sciences Metastasis Microscopy, Fluorescence Molecular modelling Mortality Mucosa Oncogene Proteins - metabolism p53 Protein Pathology Poly-ADP-Ribose Binding Proteins Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Research and Analysis Methods RNA, Small Interfering - metabolism RNA-mediated interference Surgery Therapeutic applications Tissues Tumor Suppressor Protein p53 - metabolism
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