Novosphingobium and its potential role in chronic obstructive pulmonary diseases: insights from microbiome studies

Bacterial infection of lung airways underlies some of the main complications of COPD, significantly impacting disease progression and outcome. Colonization by bacteria may further synergize, amplify, or trigger pathways of tissue damage started by cigarette smoke, contributing to the characteristic...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e111150-e111150
Hauptverfasser:	Rutebemberwa, Alleluiah, Stevens, Mark J, Perez, Mario J, Smith, Lynelle P, Sanders, Linda, Cosgrove, Gregory, Robertson, Charles E, Tuder, Rubin M, Harris, J Kirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alphaproteobacteria - isolation & purification Alphaproteobacteria - pathogenicity Alveoli Animals Bacteria Bacterial infections Biology and Life Sciences Bronchoalveolar Lavage Bronchus Cell Separation Chronic infection Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Colonization Complications Critical care Cystic fibrosis Development and progression Emphysema Exposure Female Flow Cytometry Gene sequencing Health aspects Humans Inflammation Inhalation Leukocytes (neutrophilic) Lung - metabolism Lung - microbiology Lung - physiopathology Lung diseases Lungs Macrophages Macrophages - microbiology Male Medical research Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Microbiomes Microbiota Middle Aged Neutrophils - microbiology Novosphingobium Obstructive lung disease Pediatrics Polymerase Chain Reaction Pulmonary Disease, Chronic Obstructive - microbiology Research and Analysis Methods Respiration Respiratory tract Respiratory tract diseases Ribonucleic acid RNA rRNA Sequence Analysis, DNA Smoke Smoking Smoking - adverse effects Sphingomonas Sphingomonas paucimobilis Streptococcus infections Synergism Tobacco
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