Blood levels of S-100 calcium-binding protein B, high-sensitivity C-reactive protein, and interleukin-6 for changes in depressive symptom severity after coronary artery bypass grafting: prospective cohort nested within a randomized, controlled trial

Cross-sectional and retrospective studies have associated major depressive disorder with glial activation and injury as well as blood-brain barrier disruption, but these associations have not been assessed prospectively. Here, we aimed to determine the relationship between changes in depressive symp...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e111110-e111110
Hauptverfasser:	Pearlman, Daniel M, Brown, Jeremiah R, MacKenzie, Todd A, Hernandez, Jr, Felix, Najjar, Souhel
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adult Aged Aged, 80 and over Analysis Binding proteins Biology and Life Sciences Biomarkers Biomarkers - blood Blood Blood levels Blood-brain barrier Bone surgery Brain Brain injury Brain research Bypasses C-reactive protein C-Reactive Protein - metabolism Calcium Calcium (blood) Calcium-binding protein Calmodulin Cardiology Clinical medicine Cognition Coronary artery Coronary artery bypass Coronary Artery Bypass - adverse effects Coronary vessels Cytokines Depression (Mood disorder) Depression - blood Depression - etiology Discharge Epidemiology Female Grafting Heart surgery Humans Inflammation Informed consent Interleukin 6 Interleukin-6 - blood Interleukins Male Medicine Medicine and Health Sciences Mental depression Middle Aged Postoperative Complications - blood Prospective Studies Protein B Protein binding Proteins Randomization Research and Analysis Methods S100 Calcium Binding Protein beta Subunit - blood S100b protein Sensitivity Severity of Illness Index Statistical analysis Statistical significance Surgery Traumatic brain injury Veins & arteries
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