Blood levels of S-100 calcium-binding protein B, high-sensitivity C-reactive protein, and interleukin-6 for changes in depressive symptom severity after coronary artery bypass grafting: prospective cohort nested within a randomized, controlled trial
Cross-sectional and retrospective studies have associated major depressive disorder with glial activation and injury as well as blood-brain barrier disruption, but these associations have not been assessed prospectively. Here, we aimed to determine the relationship between changes in depressive symp...
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| Veröffentlicht in: | PloS one 2014-10, Vol.9 (10), p.e111110-e111110 |
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| description | Cross-sectional and retrospective studies have associated major depressive disorder with glial activation and injury as well as blood-brain barrier disruption, but these associations have not been assessed prospectively. Here, we aimed to determine the relationship between changes in depressive symptom severity and in blood levels of S-100 calcium-binding protein B (S-100B), high-sensitivity C-reactive protein, and interleukin-6 following an inflammatory challenge.
Fifty unselected participants were recruited from a randomized, controlled trial comparing coronary artery bypass grafting procedures performed with versus without cardiopulmonary bypass for the risk of neurocognitive decline. Depressive symptom severity was measured at baseline, discharge, and six-month follow-up using the Beck Depression Inventory II (BDI-II). The primary outcome of the present biomarker study was acute change in depressive symptom severity, defined as the intra-subject difference between baseline and discharge BDI-II scores. Blood biomarker levels were determined at baseline and 2 days postoperative.
Changes in S-100B levels correlated positively with acute changes in depressive symptom severity (Spearman ρ, 0.62; P = 0.0004) and accounted for about one-fourth of their observed variance (R2, 0.23; P = 0.0105). This association remained statistically significant after adjusting for baseline S-100B levels, age, weight, body-mass index, or β-blocker use, but not baseline BDI-II scores (P = 0.064). There was no statistically significant association between the primary outcome and baseline S-100B levels, baseline high-sensitivity C-reactive protein or interleukin-6 levels, or changes in high-sensitivity C-reactive protein or interleukin-6 levels. Among most participants, levels of all three biomarkers were normal at baseline and markedly elevated at 2 days postoperative.
Acute changes in depressive symptom severity were specifically associated with incremental changes in S-100B blood levels, largely independent of covariates associated with either. These findings support the hypothesis that glial activation and injury and blood-brain barrier disruption can be mechanistically linked to acute exacerbation of depressive symptoms in some individuals. |
| doi_str_mv | 10.1371/journal.pone.0111110 |
| format | Article |
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Fifty unselected participants were recruited from a randomized, controlled trial comparing coronary artery bypass grafting procedures performed with versus without cardiopulmonary bypass for the risk of neurocognitive decline. Depressive symptom severity was measured at baseline, discharge, and six-month follow-up using the Beck Depression Inventory II (BDI-II). The primary outcome of the present biomarker study was acute change in depressive symptom severity, defined as the intra-subject difference between baseline and discharge BDI-II scores. Blood biomarker levels were determined at baseline and 2 days postoperative.
Changes in S-100B levels correlated positively with acute changes in depressive symptom severity (Spearman ρ, 0.62; P = 0.0004) and accounted for about one-fourth of their observed variance (R2, 0.23; P = 0.0105). This association remained statistically significant after adjusting for baseline S-100B levels, age, weight, body-mass index, or β-blocker use, but not baseline BDI-II scores (P = 0.064). There was no statistically significant association between the primary outcome and baseline S-100B levels, baseline high-sensitivity C-reactive protein or interleukin-6 levels, or changes in high-sensitivity C-reactive protein or interleukin-6 levels. Among most participants, levels of all three biomarkers were normal at baseline and markedly elevated at 2 days postoperative.
Acute changes in depressive symptom severity were specifically associated with incremental changes in S-100B blood levels, largely independent of covariates associated with either. These findings support the hypothesis that glial activation and injury and blood-brain barrier disruption can be mechanistically linked to acute exacerbation of depressive symptoms in some individuals.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0111110</identifier><identifier>PMID: 25329583</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Binding proteins ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Blood ; Blood levels ; Blood-brain barrier ; Bone surgery ; Brain ; Brain injury ; Brain research ; Bypasses ; C-reactive protein ; C-Reactive Protein - metabolism ; Calcium ; Calcium (blood) ; Calcium-binding protein ; Calmodulin ; Cardiology ; Clinical medicine ; Cognition ; Coronary artery ; Coronary artery bypass ; Coronary Artery Bypass - adverse effects ; Coronary vessels ; Cytokines ; Depression (Mood disorder) ; Depression - blood ; Depression - etiology ; Discharge ; Epidemiology ; Female ; Grafting ; Heart surgery ; Humans ; Inflammation ; Informed consent ; Interleukin 6 ; Interleukin-6 - blood ; Interleukins ; Male ; Medicine ; Medicine and Health Sciences ; Mental depression ; Middle Aged ; Postoperative Complications - blood ; Prospective Studies ; Protein B ; Protein binding ; Proteins ; Randomization ; Research and Analysis Methods ; S100 Calcium Binding Protein beta Subunit - blood ; S100b protein ; Sensitivity ; Severity of Illness Index ; Statistical analysis ; Statistical significance ; Surgery ; Traumatic brain injury ; Veins & arteries</subject><ispartof>PloS one, 2014-10, Vol.9 (10), p.e111110-e111110</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Pearlman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Pearlman et al 2014 Pearlman et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-7353736c719b67a31359ef36a74f7fe4f34a491cb8dab231ef7a19a7f9af7fab3</citedby><cites>FETCH-LOGICAL-c692t-7353736c719b67a31359ef36a74f7fe4f34a491cb8dab231ef7a19a7f9af7fab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203837/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203837/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25329583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pearlman, Daniel M</creatorcontrib><creatorcontrib>Brown, Jeremiah R</creatorcontrib><creatorcontrib>MacKenzie, Todd A</creatorcontrib><creatorcontrib>Hernandez, Jr, Felix</creatorcontrib><creatorcontrib>Najjar, Souhel</creatorcontrib><title>Blood levels of S-100 calcium-binding protein B, high-sensitivity C-reactive protein, and interleukin-6 for changes in depressive symptom severity after coronary artery bypass grafting: prospective cohort nested within a randomized, controlled trial</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Cross-sectional and retrospective studies have associated major depressive disorder with glial activation and injury as well as blood-brain barrier disruption, but these associations have not been assessed prospectively. Here, we aimed to determine the relationship between changes in depressive symptom severity and in blood levels of S-100 calcium-binding protein B (S-100B), high-sensitivity C-reactive protein, and interleukin-6 following an inflammatory challenge.
Fifty unselected participants were recruited from a randomized, controlled trial comparing coronary artery bypass grafting procedures performed with versus without cardiopulmonary bypass for the risk of neurocognitive decline. Depressive symptom severity was measured at baseline, discharge, and six-month follow-up using the Beck Depression Inventory II (BDI-II). The primary outcome of the present biomarker study was acute change in depressive symptom severity, defined as the intra-subject difference between baseline and discharge BDI-II scores. Blood biomarker levels were determined at baseline and 2 days postoperative.
Changes in S-100B levels correlated positively with acute changes in depressive symptom severity (Spearman ρ, 0.62; P = 0.0004) and accounted for about one-fourth of their observed variance (R2, 0.23; P = 0.0105). This association remained statistically significant after adjusting for baseline S-100B levels, age, weight, body-mass index, or β-blocker use, but not baseline BDI-II scores (P = 0.064). There was no statistically significant association between the primary outcome and baseline S-100B levels, baseline high-sensitivity C-reactive protein or interleukin-6 levels, or changes in high-sensitivity C-reactive protein or interleukin-6 levels. Among most participants, levels of all three biomarkers were normal at baseline and markedly elevated at 2 days postoperative.
Acute changes in depressive symptom severity were specifically associated with incremental changes in S-100B blood levels, largely independent of covariates associated with either. These findings support the hypothesis that glial activation and injury and blood-brain barrier disruption can be mechanistically linked to acute exacerbation of depressive symptoms in some individuals.</description><subject>Activation</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Binding proteins</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Blood-brain barrier</subject><subject>Bone surgery</subject><subject>Brain</subject><subject>Brain injury</subject><subject>Brain research</subject><subject>Bypasses</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Calcium</subject><subject>Calcium (blood)</subject><subject>Calcium-binding protein</subject><subject>Calmodulin</subject><subject>Cardiology</subject><subject>Clinical medicine</subject><subject>Cognition</subject><subject>Coronary artery</subject><subject>Coronary artery bypass</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Depression (Mood disorder)</subject><subject>Depression - blood</subject><subject>Depression - etiology</subject><subject>Discharge</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Grafting</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Informed consent</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Interleukins</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Postoperative Complications - blood</subject><subject>Prospective Studies</subject><subject>Protein B</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>Randomization</subject><subject>Research and Analysis Methods</subject><subject>S100 Calcium Binding Protein beta Subunit - blood</subject><subject>S100b protein</subject><subject>Sensitivity</subject><subject>Severity of Illness Index</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Surgery</subject><subject>Traumatic brain injury</subject><subject>Veins & arteries</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk91r1TAUwIsobk7_A9GAIArrbJp--iBsw4_BYODU15Cmp21mmtQknV7_c9883b0bu7IH24f25PzOd04UPaXJAWUlfXNhZ2eEPpisgYOELk9yL9qlNUvjIk3Y_Vv_O9Ej7y-SJGdVUTyMdtKcpXVesd3oz5G2tiUaLkF7YjtyHtMkIVJoqeYxbpRplenJ5GwAZcjRPhlUP8QejFdBXaqwIsexAyFRgGtsnwjTEmUCOA3zd2XignTWETkI04NHDWlhcuD9YuRX4xTsSDzm4BaHokNDIq2zRjgUHYor0qwm4T3pHaoxpbdLMD_BOrC0g3WBGPABWvJThQFjCOIwDzuq39DuI2KCs1qjPjgl9OPoQSe0hyeb71709cP7L8ef4tOzjyfHh6exLOo0xCXLWckKWdK6KUrBKMtr6FghyqwrO8g6lomsprKpWtGkjEJXClqLsqsF6kXD9qLna7-Ttp5vpuY5LWjGyrpMUyRO1kRrxQWfnBqxbG6F4lcH1vUce6CkBt6lQlZ5mjcJhs7zpsobVma0yJcEi1agr3ebaHMzQisBixZ6y-m2xqiB9_aSZ3hNKqx0L3q1ceDsjxn7yUflJWgtDNj5Ku88LShLK0Rf_IPeXd2G6gUWoExnMa5cnPLDjFaU1axgSB3cQeHbwqhwdNApPN8yeL1lsIwXfoVezN7zk_PP_8-efdtmX95iBxA6DN7qOShr_DaYrUGJ99A76G6aTBO-bOh1N_iyoXyzoWj27PaAboyuV5L9Bf-ZPFY</recordid><startdate>20141020</startdate><enddate>20141020</enddate><creator>Pearlman, Daniel M</creator><creator>Brown, Jeremiah R</creator><creator>MacKenzie, Todd A</creator><creator>Hernandez, Jr, Felix</creator><creator>Najjar, Souhel</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141020</creationdate><title>Blood levels of S-100 calcium-binding protein B, high-sensitivity C-reactive protein, and interleukin-6 for changes in depressive symptom severity after coronary artery bypass grafting: prospective cohort nested within a randomized, controlled trial</title><author>Pearlman, Daniel M ; Brown, Jeremiah R ; MacKenzie, Todd A ; Hernandez, Jr, Felix ; Najjar, Souhel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-7353736c719b67a31359ef36a74f7fe4f34a491cb8dab231ef7a19a7f9af7fab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Activation</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Binding proteins</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pearlman, Daniel M</au><au>Brown, Jeremiah R</au><au>MacKenzie, Todd A</au><au>Hernandez, Jr, Felix</au><au>Najjar, Souhel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood levels of S-100 calcium-binding protein B, high-sensitivity C-reactive protein, and interleukin-6 for changes in depressive symptom severity after coronary artery bypass grafting: prospective cohort nested within a randomized, controlled trial</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-10-20</date><risdate>2014</risdate><volume>9</volume><issue>10</issue><spage>e111110</spage><epage>e111110</epage><pages>e111110-e111110</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Cross-sectional and retrospective studies have associated major depressive disorder with glial activation and injury as well as blood-brain barrier disruption, but these associations have not been assessed prospectively. Here, we aimed to determine the relationship between changes in depressive symptom severity and in blood levels of S-100 calcium-binding protein B (S-100B), high-sensitivity C-reactive protein, and interleukin-6 following an inflammatory challenge.
Fifty unselected participants were recruited from a randomized, controlled trial comparing coronary artery bypass grafting procedures performed with versus without cardiopulmonary bypass for the risk of neurocognitive decline. Depressive symptom severity was measured at baseline, discharge, and six-month follow-up using the Beck Depression Inventory II (BDI-II). The primary outcome of the present biomarker study was acute change in depressive symptom severity, defined as the intra-subject difference between baseline and discharge BDI-II scores. Blood biomarker levels were determined at baseline and 2 days postoperative.
Changes in S-100B levels correlated positively with acute changes in depressive symptom severity (Spearman ρ, 0.62; P = 0.0004) and accounted for about one-fourth of their observed variance (R2, 0.23; P = 0.0105). This association remained statistically significant after adjusting for baseline S-100B levels, age, weight, body-mass index, or β-blocker use, but not baseline BDI-II scores (P = 0.064). There was no statistically significant association between the primary outcome and baseline S-100B levels, baseline high-sensitivity C-reactive protein or interleukin-6 levels, or changes in high-sensitivity C-reactive protein or interleukin-6 levels. Among most participants, levels of all three biomarkers were normal at baseline and markedly elevated at 2 days postoperative.
Acute changes in depressive symptom severity were specifically associated with incremental changes in S-100B blood levels, largely independent of covariates associated with either. These findings support the hypothesis that glial activation and injury and blood-brain barrier disruption can be mechanistically linked to acute exacerbation of depressive symptoms in some individuals.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25329583</pmid><doi>10.1371/journal.pone.0111110</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-10, Vol.9 (10), p.e111110-e111110 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1614379722 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activation Adult Aged Aged, 80 and over Analysis Binding proteins Biology and Life Sciences Biomarkers Biomarkers - blood Blood Blood levels Blood-brain barrier Bone surgery Brain Brain injury Brain research Bypasses C-reactive protein C-Reactive Protein - metabolism Calcium Calcium (blood) Calcium-binding protein Calmodulin Cardiology Clinical medicine Cognition Coronary artery Coronary artery bypass Coronary Artery Bypass - adverse effects Coronary vessels Cytokines Depression (Mood disorder) Depression - blood Depression - etiology Discharge Epidemiology Female Grafting Heart surgery Humans Inflammation Informed consent Interleukin 6 Interleukin-6 - blood Interleukins Male Medicine Medicine and Health Sciences Mental depression Middle Aged Postoperative Complications - blood Prospective Studies Protein B Protein binding Proteins Randomization Research and Analysis Methods S100 Calcium Binding Protein beta Subunit - blood S100b protein Sensitivity Severity of Illness Index Statistical analysis Statistical significance Surgery Traumatic brain injury Veins & arteries |
| title | Blood levels of S-100 calcium-binding protein B, high-sensitivity C-reactive protein, and interleukin-6 for changes in depressive symptom severity after coronary artery bypass grafting: prospective cohort nested within a randomized, controlled trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T07%3A34%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Blood%20levels%20of%20S-100%20calcium-binding%20protein%20B,%20high-sensitivity%20C-reactive%20protein,%20and%20interleukin-6%20for%20changes%20in%20depressive%20symptom%20severity%20after%20coronary%20artery%20bypass%20grafting:%20prospective%20cohort%20nested%20within%20a%20randomized,%20controlled%20trial&rft.jtitle=PloS%20one&rft.au=Pearlman,%20Daniel%20M&rft.date=2014-10-20&rft.volume=9&rft.issue=10&rft.spage=e111110&rft.epage=e111110&rft.pages=e111110-e111110&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0111110&rft_dat=%3Cgale_plos_%3EA418139363%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1614379722&rft_id=info:pmid/25329583&rft_galeid=A418139363&rft_doaj_id=oai_doaj_org_article_f2ac8525b0fe455b85b3741656c716da&rfr_iscdi=true |