Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes

Ursolic acid (UA), a triterpenoid compound, is reported to have a glucose-lowering effect. However, the mechanisms are not fully understood. Adipose tissue is one of peripheral tissues that collectively control the circulating glucose levels. The objective of the present study was to determine the e...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110711-e110711
Hauptverfasser:	He, Yonghan, Li, Wen, Li, Ying, Zhang, Shuocheng, Wang, Yanwen, Sun, Changhao
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 3T3-L1 Cells Acids Adipocytes Adipocytes - cytology Adipocytes - metabolism Adipose tissue AKT protein AMP Animals Anti-Infective Agents - pharmacology Biology and Life Sciences Cell Membrane - metabolism Councils Crop diseases Cytoplasm Cytoplasm - metabolism Diabetes Diabetes mellitus Enzyme inhibitors Fluorescence Glucose Glucose - metabolism Glucose transport Glucose transporter Glucose Transporter Type 4 - metabolism Homeostasis Hygiene Inhibitors Insulin Insulin resistance Kinases Laboratories Life sciences Liver diseases MAP kinase Medicine and Health Sciences Metabolism Mice Nutrition research Phosphatidylinositol 3-Kinases - metabolism Preadipocytes Protein kinase C Protein Kinase Inhibitors - pharmacology Protein Transport - drug effects Proteins Public health Rodents Signal transduction Signal Transduction - drug effects Signaling Tissues Translocation Triterpenes - pharmacology Ursolic Acid Western blotting Wortmannin
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