Aerobic exercise training prevents heart failure-induced skeletal muscle atrophy by anti-catabolic, but not anabolic actions

Heart failure (HF) is associated with cachexia and consequent exercise intolerance. Given the beneficial effects of aerobic exercise training (ET) in HF, the aim of this study was to determine if the ET performed during the transition from cardiac dysfunction to HF would alter the expression of anab...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110020-e110020
Hauptverfasser:	Souza, Rodrigo W A, Piedade, Warlen P, Soares, Luana C, Souza, Paula A T, Aguiar, Andreo F, Vechetti-Júnior, Ivan J, Campos, Dijon H S, Fernandes, Ana A H, Okoshi, Katashi, Carvalho, Robson F, Cicogna, Antonio C, Dal-Pai-Silva, Maeli
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Aorta Aortic stenosis Atrophy Biochemistry Biology and Life Sciences Cachexia Dietary fiber Exercise Fitness training programs Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXO1 protein Health aspects Heart Heart diseases Heart failure Heart Failure - complications Insulin-like growth factor I Insulin-like growth factors Internal medicine Intolerance Laboratory animals Male Medicine and Health Sciences Metabolism Morphology Muscle Proteins - genetics Muscle Proteins - metabolism Muscle, Skeletal - metabolism Muscles Muscular Atrophy - etiology Muscular Atrophy - prevention & control Musculoskeletal system Myostatin Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Ostomy Physical Exertion Protein synthesis Proteins Rats Rats, Wistar Rodents Serum levels Skeletal muscle SKP Cullin F-Box Protein Ligases - genetics SKP Cullin F-Box Protein Ligases - metabolism Stenosis Surgery TOR protein Training Tripartite Motif Proteins Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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