Effects of vivo morpholino knockdown of lateral hypothalamus orexin/hypocretin on renewal of alcohol seeking

Two experiments used vivo morpholinos to assess the role of orexin/hypocretin in ABA renewal of extinguished alcohol seeking. Rats were trained to respond for alcoholic beer in a distinctive context, A, and then extinguished in a second distinctive context, B. When rats were tested in the extinction...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110385
Hauptverfasser:	Prasad, Asheeta A, McNally, Gavan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohol use Alcoholism - genetics Alcoholism - physiopathology Alcohols Analysis of Variance Animal behavior Animals Antisense Antisense therapy Beer Biology and Life Sciences Cocaine Drug-Seeking Behavior - physiology Experiments Extinction Food Gene Knockdown Techniques Heroin Hypothalamic Area, Lateral - metabolism Hypothalamic Hormones - metabolism Hypothalamus Hypothalamus (lateral) Immunohistochemistry Intracellular Signaling Peptides and Proteins - metabolism Laboratory animals Luteinizing hormone Male Melanin Melanins - metabolism Microinjection Microinjections Morpholinos - administration & dosage Morpholinos - genetics Neuropeptides Neuropeptides - metabolism Orexins Pituitary Hormones - metabolism Protein expression Proteins Psychopharmacology Rats Rats, Long-Evans Surgery
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