Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate
Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo, sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism of Meniere's disease is still unclear. In this study, we evaluated autoimmunity as a potential cause of Meniere&#...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-10, Vol.9 (10), p.e111039-e111039 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e111039 |
|---|---|
| container_issue | 10 |
| container_start_page | e111039 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Kim, Sung Huhn Kim, Jin Young Lee, Hyun Jin Gi, Mia Kim, Bo Gyung Choi, Jae Young |
| description | Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo, sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism of Meniere's disease is still unclear. In this study, we evaluated autoimmunity as a potential cause of Meniere's disease. In addition we tried to find useful biomarker candidates for diagnosis. We investigated the protein composition of human inner ear fluid using liquid column mass spectrometry, the autoimmune reaction between circulating autoantibodies in patient serum and multiple antigens using the Protoarray system, the immune reaction between patient serum and mouse inner ear tissues using western blot analysis. Nine proteins, including immunoglobulin and its variants and interferon regulatory factor 7, were found only in the inner ear fluid of patients with Meniere's disease. Enhanced immune reactions with 18 candidate antigens were detected in patients with Meniere's disease in Protoarray analysis; levels of 8 of these antigens were more than 10-fold higher in patients than in controls. Antigen-antibody reactions between mouse inner ear proteins with molecular weights of 23-48 kDa and 63-75 kDa and patient sera were detected in 8 patients. These findings suggest that autoimmunity could be one of the pathologic mechanisms behind Meniere's disease. Multiple autoantibodies and antigens may be involved in the autoimmune reaction. Specific antigens that caused immune reactions with patient's serum in Protoarray analysis can be candidates for the diagnostic biomarkers of Meniere's disease. |
| doi_str_mv | 10.1371/journal.pone.0111039 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1613423941</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A418424598</galeid><doaj_id>oai_doaj_org_article_d9cf98df81ba419ea0bb2bde5cb85696</doaj_id><sourcerecordid>A418424598</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-17c08c81889e4ed45eeb312459343790b7e0fa8fbf4be479ef8e615f271e42db3</originalsourceid><addsrcrecordid>eNqNk1uPEyEUxydG466r38DoJJt4eWiFgZmCDybNxkuTNZt4eyUMHFrqDFRgjPsp_MrS29qafTA8QA6_8z8XOEXxGKMxJhP8aumH4GQ3XnkHY4QxRoTfKU4xJ9WoqRC5e3A-KR7EuESoJqxp7hcnVU0IIqQ5LX5Ph-Rt3w_OputSxlKWSjpttUxQGh_KtIASkvUrmRZ-Dg6ijaU35UdwFgI8j6W2EWSE16WGBCqjbn0v97pQBpAbcxZ3OuNy7nxMVpWt9b0M3yH8jfmwuGdkF-HRbj8rvr57--Xiw-jy6v3sYno5Ug2v0ghPFGKKYcY4UNC0BmgJrmjNCSUTjtoJICOZaQ1tgU44GAYNrk01wUAr3ZKz4ulWd9X5KHa9jAI3mNCKcIozMdsS2sulWAWbU70WXlqxMfgwFzLkKjoQmivDmTYMt5JiDhK1bdVqqFXL6oY3WevNLtrQ9qAVuBRkdyR6fOPsQsz9T0ErhGuGssCLnUDwPwaISfQ2Kug66cAPm7zrqkG8rjJ6_g96e3U7ai5zAdYZn-OqtaiYUszoupUsU-NbqLw09Fblj2dsth85vDxyyEyCX2kuhxjF7POn_2evvh2zzw7YBcguLaLvhs23OgbpFlTBxxjA3DQZI7Gem303xHpuxG5ustuTwwe6cdoPCvkD8KkV5Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1613423941</pqid></control><display><type>article</type><title>Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Kim, Sung Huhn ; Kim, Jin Young ; Lee, Hyun Jin ; Gi, Mia ; Kim, Bo Gyung ; Choi, Jae Young</creator><contributor>Sokolowski, Bernd</contributor><creatorcontrib>Kim, Sung Huhn ; Kim, Jin Young ; Lee, Hyun Jin ; Gi, Mia ; Kim, Bo Gyung ; Choi, Jae Young ; Sokolowski, Bernd</creatorcontrib><description>Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo, sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism of Meniere's disease is still unclear. In this study, we evaluated autoimmunity as a potential cause of Meniere's disease. In addition we tried to find useful biomarker candidates for diagnosis. We investigated the protein composition of human inner ear fluid using liquid column mass spectrometry, the autoimmune reaction between circulating autoantibodies in patient serum and multiple antigens using the Protoarray system, the immune reaction between patient serum and mouse inner ear tissues using western blot analysis. Nine proteins, including immunoglobulin and its variants and interferon regulatory factor 7, were found only in the inner ear fluid of patients with Meniere's disease. Enhanced immune reactions with 18 candidate antigens were detected in patients with Meniere's disease in Protoarray analysis; levels of 8 of these antigens were more than 10-fold higher in patients than in controls. Antigen-antibody reactions between mouse inner ear proteins with molecular weights of 23-48 kDa and 63-75 kDa and patient sera were detected in 8 patients. These findings suggest that autoimmunity could be one of the pathologic mechanisms behind Meniere's disease. Multiple autoantibodies and antigens may be involved in the autoimmune reaction. Specific antigens that caused immune reactions with patient's serum in Protoarray analysis can be candidates for the diagnostic biomarkers of Meniere's disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0111039</identifier><identifier>PMID: 25330336</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Animals ; Antigens ; Antigens - blood ; Antigens - immunology ; Antigens - isolation & purification ; Autoantibodies ; Autoantibodies - blood ; Autoimmune diseases ; Autoimmunity ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Diagnostic systems ; Ear ; Ear, Inner - immunology ; Ear, Inner - pathology ; Happiness ; Hearing loss ; Hearing Loss, Sensorineural - blood ; Hearing Loss, Sensorineural - immunology ; Hearing Loss, Sensorineural - physiopathology ; Hearing protection ; Humans ; Inner ear ; Interferon ; Interferon regulatory factor ; Interferon regulatory factor 7 ; Mass spectrometry ; Mass spectroscopy ; Medical diagnosis ; Medicine and Health Sciences ; Meniere Disease - blood ; Meniere Disease - etiology ; Meniere Disease - immunology ; Meniere Disease - physiopathology ; Meniere's disease ; Mice ; Middle Aged ; Otolaryngology ; Patients ; Protein composition ; Proteins ; Studies ; Systemic lupus erythematosus ; Tinnitus ; Tissues ; Vertigo</subject><ispartof>PloS one, 2014-10, Vol.9 (10), p.e111039-e111039</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Kim et al 2014 Kim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-17c08c81889e4ed45eeb312459343790b7e0fa8fbf4be479ef8e615f271e42db3</citedby><cites>FETCH-LOGICAL-c692t-17c08c81889e4ed45eeb312459343790b7e0fa8fbf4be479ef8e615f271e42db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201580/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201580/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25330336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sokolowski, Bernd</contributor><creatorcontrib>Kim, Sung Huhn</creatorcontrib><creatorcontrib>Kim, Jin Young</creatorcontrib><creatorcontrib>Lee, Hyun Jin</creatorcontrib><creatorcontrib>Gi, Mia</creatorcontrib><creatorcontrib>Kim, Bo Gyung</creatorcontrib><creatorcontrib>Choi, Jae Young</creatorcontrib><title>Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo, sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism of Meniere's disease is still unclear. In this study, we evaluated autoimmunity as a potential cause of Meniere's disease. In addition we tried to find useful biomarker candidates for diagnosis. We investigated the protein composition of human inner ear fluid using liquid column mass spectrometry, the autoimmune reaction between circulating autoantibodies in patient serum and multiple antigens using the Protoarray system, the immune reaction between patient serum and mouse inner ear tissues using western blot analysis. Nine proteins, including immunoglobulin and its variants and interferon regulatory factor 7, were found only in the inner ear fluid of patients with Meniere's disease. Enhanced immune reactions with 18 candidate antigens were detected in patients with Meniere's disease in Protoarray analysis; levels of 8 of these antigens were more than 10-fold higher in patients than in controls. Antigen-antibody reactions between mouse inner ear proteins with molecular weights of 23-48 kDa and 63-75 kDa and patient sera were detected in 8 patients. These findings suggest that autoimmunity could be one of the pathologic mechanisms behind Meniere's disease. Multiple autoantibodies and antigens may be involved in the autoimmune reaction. Specific antigens that caused immune reactions with patient's serum in Protoarray analysis can be candidates for the diagnostic biomarkers of Meniere's disease.</description><subject>Adult</subject><subject>Analysis</subject><subject>Animals</subject><subject>Antigens</subject><subject>Antigens - blood</subject><subject>Antigens - immunology</subject><subject>Antigens - isolation & purification</subject><subject>Autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune diseases</subject><subject>Autoimmunity</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Diagnostic systems</subject><subject>Ear</subject><subject>Ear, Inner - immunology</subject><subject>Ear, Inner - pathology</subject><subject>Happiness</subject><subject>Hearing loss</subject><subject>Hearing Loss, Sensorineural - blood</subject><subject>Hearing Loss, Sensorineural - immunology</subject><subject>Hearing Loss, Sensorineural - physiopathology</subject><subject>Hearing protection</subject><subject>Humans</subject><subject>Inner ear</subject><subject>Interferon</subject><subject>Interferon regulatory factor</subject><subject>Interferon regulatory factor 7</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medical diagnosis</subject><subject>Medicine and Health Sciences</subject><subject>Meniere Disease - blood</subject><subject>Meniere Disease - etiology</subject><subject>Meniere Disease - immunology</subject><subject>Meniere Disease - physiopathology</subject><subject>Meniere's disease</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Otolaryngology</subject><subject>Patients</subject><subject>Protein composition</subject><subject>Proteins</subject><subject>Studies</subject><subject>Systemic lupus erythematosus</subject><subject>Tinnitus</subject><subject>Tissues</subject><subject>Vertigo</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uPEyEUxydG466r38DoJJt4eWiFgZmCDybNxkuTNZt4eyUMHFrqDFRgjPsp_MrS29qafTA8QA6_8z8XOEXxGKMxJhP8aumH4GQ3XnkHY4QxRoTfKU4xJ9WoqRC5e3A-KR7EuESoJqxp7hcnVU0IIqQ5LX5Ph-Rt3w_OputSxlKWSjpttUxQGh_KtIASkvUrmRZ-Dg6ijaU35UdwFgI8j6W2EWSE16WGBCqjbn0v97pQBpAbcxZ3OuNy7nxMVpWt9b0M3yH8jfmwuGdkF-HRbj8rvr57--Xiw-jy6v3sYno5Ug2v0ghPFGKKYcY4UNC0BmgJrmjNCSUTjtoJICOZaQ1tgU44GAYNrk01wUAr3ZKz4ulWd9X5KHa9jAI3mNCKcIozMdsS2sulWAWbU70WXlqxMfgwFzLkKjoQmivDmTYMt5JiDhK1bdVqqFXL6oY3WevNLtrQ9qAVuBRkdyR6fOPsQsz9T0ErhGuGssCLnUDwPwaISfQ2Kug66cAPm7zrqkG8rjJ6_g96e3U7ai5zAdYZn-OqtaiYUszoupUsU-NbqLw09Fblj2dsth85vDxyyEyCX2kuhxjF7POn_2evvh2zzw7YBcguLaLvhs23OgbpFlTBxxjA3DQZI7Gem303xHpuxG5ustuTwwe6cdoPCvkD8KkV5Q</recordid><startdate>20141017</startdate><enddate>20141017</enddate><creator>Kim, Sung Huhn</creator><creator>Kim, Jin Young</creator><creator>Lee, Hyun Jin</creator><creator>Gi, Mia</creator><creator>Kim, Bo Gyung</creator><creator>Choi, Jae Young</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141017</creationdate><title>Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate</title><author>Kim, Sung Huhn ; Kim, Jin Young ; Lee, Hyun Jin ; Gi, Mia ; Kim, Bo Gyung ; Choi, Jae Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-17c08c81889e4ed45eeb312459343790b7e0fa8fbf4be479ef8e615f271e42db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Animals</topic><topic>Antigens</topic><topic>Antigens - blood</topic><topic>Antigens - immunology</topic><topic>Antigens - isolation & purification</topic><topic>Autoantibodies</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune diseases</topic><topic>Autoimmunity</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Diagnostic systems</topic><topic>Ear</topic><topic>Ear, Inner - immunology</topic><topic>Ear, Inner - pathology</topic><topic>Happiness</topic><topic>Hearing loss</topic><topic>Hearing Loss, Sensorineural - blood</topic><topic>Hearing Loss, Sensorineural - immunology</topic><topic>Hearing Loss, Sensorineural - physiopathology</topic><topic>Hearing protection</topic><topic>Humans</topic><topic>Inner ear</topic><topic>Interferon</topic><topic>Interferon regulatory factor</topic><topic>Interferon regulatory factor 7</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medical diagnosis</topic><topic>Medicine and Health Sciences</topic><topic>Meniere Disease - blood</topic><topic>Meniere Disease - etiology</topic><topic>Meniere Disease - immunology</topic><topic>Meniere Disease - physiopathology</topic><topic>Meniere's disease</topic><topic>Mice</topic><topic>Middle Aged</topic><topic>Otolaryngology</topic><topic>Patients</topic><topic>Protein composition</topic><topic>Proteins</topic><topic>Studies</topic><topic>Systemic lupus erythematosus</topic><topic>Tinnitus</topic><topic>Tissues</topic><topic>Vertigo</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sung Huhn</creatorcontrib><creatorcontrib>Kim, Jin Young</creatorcontrib><creatorcontrib>Lee, Hyun Jin</creatorcontrib><creatorcontrib>Gi, Mia</creatorcontrib><creatorcontrib>Kim, Bo Gyung</creatorcontrib><creatorcontrib>Choi, Jae Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sung Huhn</au><au>Kim, Jin Young</au><au>Lee, Hyun Jin</au><au>Gi, Mia</au><au>Kim, Bo Gyung</au><au>Choi, Jae Young</au><au>Sokolowski, Bernd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-10-17</date><risdate>2014</risdate><volume>9</volume><issue>10</issue><spage>e111039</spage><epage>e111039</epage><pages>e111039-e111039</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo, sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism of Meniere's disease is still unclear. In this study, we evaluated autoimmunity as a potential cause of Meniere's disease. In addition we tried to find useful biomarker candidates for diagnosis. We investigated the protein composition of human inner ear fluid using liquid column mass spectrometry, the autoimmune reaction between circulating autoantibodies in patient serum and multiple antigens using the Protoarray system, the immune reaction between patient serum and mouse inner ear tissues using western blot analysis. Nine proteins, including immunoglobulin and its variants and interferon regulatory factor 7, were found only in the inner ear fluid of patients with Meniere's disease. Enhanced immune reactions with 18 candidate antigens were detected in patients with Meniere's disease in Protoarray analysis; levels of 8 of these antigens were more than 10-fold higher in patients than in controls. Antigen-antibody reactions between mouse inner ear proteins with molecular weights of 23-48 kDa and 63-75 kDa and patient sera were detected in 8 patients. These findings suggest that autoimmunity could be one of the pathologic mechanisms behind Meniere's disease. Multiple autoantibodies and antigens may be involved in the autoimmune reaction. Specific antigens that caused immune reactions with patient's serum in Protoarray analysis can be candidates for the diagnostic biomarkers of Meniere's disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25330336</pmid><doi>10.1371/journal.pone.0111039</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-10, Vol.9 (10), p.e111039-e111039 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1613423941 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Analysis Animals Antigens Antigens - blood Antigens - immunology Antigens - isolation & purification Autoantibodies Autoantibodies - blood Autoimmune diseases Autoimmunity Biology and Life Sciences Biomarkers Biomarkers - blood Diagnostic systems Ear Ear, Inner - immunology Ear, Inner - pathology Happiness Hearing loss Hearing Loss, Sensorineural - blood Hearing Loss, Sensorineural - immunology Hearing Loss, Sensorineural - physiopathology Hearing protection Humans Inner ear Interferon Interferon regulatory factor Interferon regulatory factor 7 Mass spectrometry Mass spectroscopy Medical diagnosis Medicine and Health Sciences Meniere Disease - blood Meniere Disease - etiology Meniere Disease - immunology Meniere Disease - physiopathology Meniere's disease Mice Middle Aged Otolaryngology Patients Protein composition Proteins Studies Systemic lupus erythematosus Tinnitus Tissues Vertigo |
| title | Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T16%3A32%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Autoimmunity%20as%20a%20candidate%20for%20the%20etiopathogenesis%20of%20Meniere's%20disease:%20detection%20of%20autoimmune%20reactions%20and%20diagnostic%20biomarker%20candidate&rft.jtitle=PloS%20one&rft.au=Kim,%20Sung%20Huhn&rft.date=2014-10-17&rft.volume=9&rft.issue=10&rft.spage=e111039&rft.epage=e111039&rft.pages=e111039-e111039&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0111039&rft_dat=%3Cgale_plos_%3EA418424598%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1613423941&rft_id=info:pmid/25330336&rft_galeid=A418424598&rft_doaj_id=oai_doaj_org_article_d9cf98df81ba419ea0bb2bde5cb85696&rfr_iscdi=true |