Tumorigenesis of papillary thyroid cancer is not BRAF-dependent in patients with acromegaly

Several studies have reported a high frequency of papillary thyroid cancer (PTC) in patients with acromegaly. The aim of this study was to determine the prevalence and predictors of thyroid cancer in patients with acromegaly and to investigate the frequency of the BRAFV600E mutation in PTC patients...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110241
Hauptverfasser:	Kim, Hee Kyung, Lee, Ji Shin, Park, Min Ho, Cho, Jin Seong, Yoon, Jee Hee, Kim, Soo Jeong, Kang, Ho-Cheol
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly Acromegaly - complications Acromegaly - diagnosis Acromegaly - genetics Adult Analysis Cancer Cancer patients Carcinogenesis - genetics Carcinoma - complications Carcinoma - diagnosis Carcinoma - genetics Carcinoma, Papillary Care and treatment Deoxyribonucleic acid Disease DNA Female Growth hormone Growth hormones Hospitals Humans Insulin Insulin-like growth factor I Insulin-like growth factors Internal medicine Kinases Male Malignancy Medical diagnosis Medical prognosis Medical schools Medicine Medicine and Health Sciences Middle Aged Mutation Nodules Papillary thyroid cancer Paraffin Patients Polymerase chain reaction Proto-Oncogene Proteins B-raf - genetics Somatotropin Staining Surgery Thyroid Thyroid cancer Thyroid Cancer, Papillary Thyroid Neoplasms - complications Thyroid Neoplasms - diagnosis Thyroid Neoplasms - genetics Tissues Tumorigenesis Tumors Ultrasound Ultrasound imaging
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