MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression

A disintegrin and metalloproteinase15 (ADAM15) has been shown to be upregulated and mediate endothelial hyperpermeability during inflammation and sepsis. This molecule contains multiple functional domains with the ability to modulate diverse cellular processes including cell adhesion, extracellular...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110286-e110286
Hauptverfasser:	Chatterjee, Victor, Beard, Jr, Richard S, Reynolds, Jason J, Haines, Ricci, Guo, Mingzhang, Rubin, Matthew, Guido, Jenny, Wu, Mack H, Yuan, Sarah Y
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions ADAM Proteins - chemistry ADAM Proteins - genetics ADAM Proteins - metabolism Angiogenesis Base Sequence Binding Sites Biodegradation Biology and Life Sciences Blood-Air Barrier - metabolism Cancer Cell adhesion Cell adhesion & migration Cell cycle Cell Membrane - metabolism Cell surface Down-Regulation Endothelial cells Endothelial Cells - metabolism Endothelium Endothelium, Vascular - metabolism Extracellular matrix Gene expression Gene Expression Regulation Gene therapy Health aspects Human Umbilical Vein Endothelial Cells Humans Immunophenotyping Infection Inflammation Inflammatory bowel disease Kinases Lipopolysaccharides Luciferase Medicine Membrane proteins Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Metastasis MicroRNA MicroRNAs MicroRNAs - chemistry MicroRNAs - genetics miRNA Neutrophils Permeability Pharmacology Physiology Proteins Ribonucleic acid RNA RNA Interference Rodents Sepsis Surgery Therapeutic applications Transfection
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