Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma

The contribution of chronic hepatitis B virus (HBV) infection in the pathogenesis of hepatocellular carcinoma (HCC) through progressive stages of liver fibrosis is exacerbated by the acquisition of naturally occurring mutations in its genome. This study has investigated the prevalence of single and...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110012-e110012
Hauptverfasser:	Datta, Somenath, Ghosh, Alip, Dasgupta, Debanjali, Ghosh, Amit, Roychoudhury, Shrabasti, Roy, Gaurav, Das, Soumyojit, Das, Kausik, Gupta, Subash, Basu, Keya, Basu, Analabha, Datta, Simanti, Chowdhury, Abhijit, Banerjee, Soma
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigenic determinants Antigens Biology and life sciences Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - virology Care and treatment Chronic infection Clinical outcomes Comparative analysis Cytotoxicity Development and progression Disease Progression DNA, Viral Epitopes Female Fibrosis Gastroenterology Gene sequencing Genetic aspects Genome, Viral Genomes Genomics Genotype & phenotype Genotypes Health aspects Health education Hepatitis Hepatitis B Hepatitis B e antigen Hepatitis B virus Hepatitis B virus - genetics Hepatitis B, Chronic - pathology Hepatitis B, Chronic - virology Hepatocellular carcinoma Hepatology Humans Infection Infections Liver Liver - pathology Liver - virology Liver cancer Liver cirrhosis Liver diseases Liver Neoplasms - pathology Liver Neoplasms - virology Lymphocytes B Lymphocytes T Male Medical residencies Medical treatment Medicine and Health Sciences Middle Aged Mutation Nucleotide sequence Pathogenesis Patients Predictions Promoters (Genetics) Risk analysis Risk factors T cells Virology Viruses Young Adult
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