Rad51 activates polyomavirus JC early transcription

The human neurotropic polyomavirus JC (JCV) causes the fatal CNS demyelinating disease progressive multifocal leukoencephalopathy (PML). JCV infection is very common and after primary infection, the virus is able to persist in an asymptomatic state. Rarely, and usually only under conditions of immun...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e110122
Hauptverfasser:	White, Martyn K, Kaminski, Rafal, Khalili, Kamel, Wollebo, Hassen S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Activation Antigens Astrocytes Binding sites Biology and Life Sciences Brain Butyric Acid - pharmacology CCAAT-Enhancer-Binding Protein-beta - metabolism Cell cycle Cell Fractionation Cell Line, Tumor Cell Nucleus - drug effects Cell Nucleus - metabolism Cellular proteins Central nervous system Cytokines Cytokines - pharmacology Demyelination Deoxyribonucleic acid DNA DNA damage DNA repair DNA, Intergenic - genetics Double-strand break repair Epigenetic inheritance Epigenetics Gene expression Genes, Dominant Genes, Reporter Genomes Health aspects Histone deacetylase HIV Homologous recombination Homology Human immunodeficiency virus Humans I-kappa B Proteins - metabolism Infection Infections JC Virus - drug effects JC Virus - genetics Kinases Leukoencephalopathy Medicine Medicine and Health Sciences Mutation Mutation - genetics Neurosciences NF-κB protein Oligodendrocytes Plasmids Positive feedback Progressive multifocal leukoencephalopathy Promoter Regions, Genetic - genetics Protein Binding - drug effects Protein Binding - genetics Protein Isoforms - metabolism Protein Transport - drug effects Proteins Rad51 Recombinase - metabolism Repair RNA, Small Interfering - metabolism siRNA Sodium Sodium butyrate Transcription (Genetics) Transcription Factor RelA - metabolism Transcription factors Transcription, Genetic - drug effects Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumor necrosis factor-α Virology Viruses
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