Dietary protein intake and coronary heart disease in a large community based cohort: results from the Atherosclerosis Risk in Communities (ARIC) study [corrected]
Prospective data examining the relationship between dietary protein intake and incident coronary heart disease (CHD) are inconclusive. Most evidence is derived from homogenous populations such as health professionals. Large community-based analyses in more diverse samples are lacking. We studied the...
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| description | Prospective data examining the relationship between dietary protein intake and incident coronary heart disease (CHD) are inconclusive. Most evidence is derived from homogenous populations such as health professionals. Large community-based analyses in more diverse samples are lacking.
We studied the association of protein type and major dietary protein sources and risk for incident CHD in 12,066 middle-aged adults (aged 45-64 at baseline, 1987-1989) from four U.S. communities enrolled in the Atherosclerosis Risk in Communities (ARIC) Study who were free of diabetes mellitus and cardiovascular disease at baseline. Dietary protein intake was assessed at baseline and after 6 years of follow-up by food frequency questionnaire. Our primary outcome was adjudicated coronary heart disease events or deaths with following up through December 31, 2010. Cox proportional hazard models with multivariable adjustment were used for statistical analyses.
During a median follow-up of 22 years, there were 1,147 CHD events. In multivariable analyses total, animal and vegetable protein were not associated with an increased risk for CHD before or after adjustment. In food group analyses of major dietary protein sources, protein intake from red and processed meat, dairy products, fish, nuts, eggs, and legumes were not significantly associated with CHD risk. The hazard ratios [with 95% confidence intervals] for risk of CHD across quintiles of protein from poultry were 1.00 [ref], 0.83 [0.70-0.99], 0.93 [0.75-1.15], 0.88 [0.73-1.06], 0.79 [0.64-0.98], P for trend = 0.16). Replacement analyses evaluating the association of substituting one source of dietary protein for another or of decreasing protein intake at the expense of carbohydrates or total fats did not show any statistically significant association with CHD risk.
Based on a large community cohort we found no overall relationship between protein type and major dietary protein sources and risk for CHD. |
| doi_str_mv | 10.1371/journal.pone.0109552 |
| format | Article |
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We studied the association of protein type and major dietary protein sources and risk for incident CHD in 12,066 middle-aged adults (aged 45-64 at baseline, 1987-1989) from four U.S. communities enrolled in the Atherosclerosis Risk in Communities (ARIC) Study who were free of diabetes mellitus and cardiovascular disease at baseline. Dietary protein intake was assessed at baseline and after 6 years of follow-up by food frequency questionnaire. Our primary outcome was adjudicated coronary heart disease events or deaths with following up through December 31, 2010. Cox proportional hazard models with multivariable adjustment were used for statistical analyses.
During a median follow-up of 22 years, there were 1,147 CHD events. In multivariable analyses total, animal and vegetable protein were not associated with an increased risk for CHD before or after adjustment. In food group analyses of major dietary protein sources, protein intake from red and processed meat, dairy products, fish, nuts, eggs, and legumes were not significantly associated with CHD risk. The hazard ratios [with 95% confidence intervals] for risk of CHD across quintiles of protein from poultry were 1.00 [ref], 0.83 [0.70-0.99], 0.93 [0.75-1.15], 0.88 [0.73-1.06], 0.79 [0.64-0.98], P for trend = 0.16). Replacement analyses evaluating the association of substituting one source of dietary protein for another or of decreasing protein intake at the expense of carbohydrates or total fats did not show any statistically significant association with CHD risk.
Based on a large community cohort we found no overall relationship between protein type and major dietary protein sources and risk for CHD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0109552</identifier><identifier>PMID: 25303709</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adults ; Arteriosclerosis ; Atherosclerosis ; Biology and Life Sciences ; Carbohydrates ; Cardiovascular disease ; Cardiovascular diseases ; Cohort Studies ; Confidence intervals ; Coronary artery disease ; Coronary Disease - epidemiology ; Coronary Disease - etiology ; Dairy products ; Diabetes mellitus ; Diet ; Dietary intake ; Dietary Proteins - adverse effects ; Disease prevention ; Eggs ; Exercise ; Fats ; Female ; Food groups ; Health risk assessment ; Heart ; Heart diseases ; Humans ; Incidence ; Legumes ; Male ; Meat ; Medical personnel ; Medicine and Health Sciences ; Middle Aged ; Nutrition Surveys ; Nuts ; Prospective Studies ; Protein sources ; Risk ; Statistical analysis ; Statistical methods ; United States - epidemiology ; Womens health</subject><ispartof>PloS one, 2014-10, Vol.9 (10), p.e109552</ispartof><rights>2014 Haring et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Haring et al 2014 Haring et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-58e5c0f248e1baaa04a93421b2027d7676ff5ab48796564f2cb128c1a849a4e83</citedby><cites>FETCH-LOGICAL-c522t-58e5c0f248e1baaa04a93421b2027d7676ff5ab48796564f2cb128c1a849a4e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193805/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193805/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25303709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bayer, Antony</contributor><creatorcontrib>Haring, Bernhard</creatorcontrib><creatorcontrib>Gronroos, Noelle</creatorcontrib><creatorcontrib>Nettleton, Jennifer A</creatorcontrib><creatorcontrib>von Ballmoos, Moritz C Wyler</creatorcontrib><creatorcontrib>Selvin, Elizabeth</creatorcontrib><creatorcontrib>Alonso, Alvaro</creatorcontrib><title>Dietary protein intake and coronary heart disease in a large community based cohort: results from the Atherosclerosis Risk in Communities (ARIC) study [corrected]</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Prospective data examining the relationship between dietary protein intake and incident coronary heart disease (CHD) are inconclusive. Most evidence is derived from homogenous populations such as health professionals. Large community-based analyses in more diverse samples are lacking.
We studied the association of protein type and major dietary protein sources and risk for incident CHD in 12,066 middle-aged adults (aged 45-64 at baseline, 1987-1989) from four U.S. communities enrolled in the Atherosclerosis Risk in Communities (ARIC) Study who were free of diabetes mellitus and cardiovascular disease at baseline. Dietary protein intake was assessed at baseline and after 6 years of follow-up by food frequency questionnaire. Our primary outcome was adjudicated coronary heart disease events or deaths with following up through December 31, 2010. Cox proportional hazard models with multivariable adjustment were used for statistical analyses.
During a median follow-up of 22 years, there were 1,147 CHD events. In multivariable analyses total, animal and vegetable protein were not associated with an increased risk for CHD before or after adjustment. In food group analyses of major dietary protein sources, protein intake from red and processed meat, dairy products, fish, nuts, eggs, and legumes were not significantly associated with CHD risk. The hazard ratios [with 95% confidence intervals] for risk of CHD across quintiles of protein from poultry were 1.00 [ref], 0.83 [0.70-0.99], 0.93 [0.75-1.15], 0.88 [0.73-1.06], 0.79 [0.64-0.98], P for trend = 0.16). Replacement analyses evaluating the association of substituting one source of dietary protein for another or of decreasing protein intake at the expense of carbohydrates or total fats did not show any statistically significant association with CHD risk.
Based on a large community cohort we found no overall relationship between protein type and major dietary protein sources and risk for CHD.</description><subject>Adults</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biology and Life Sciences</subject><subject>Carbohydrates</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - etiology</subject><subject>Dairy products</subject><subject>Diabetes mellitus</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Dietary Proteins - adverse effects</subject><subject>Disease prevention</subject><subject>Eggs</subject><subject>Exercise</subject><subject>Fats</subject><subject>Female</subject><subject>Food groups</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Legumes</subject><subject>Male</subject><subject>Meat</subject><subject>Medical personnel</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nutrition Surveys</subject><subject>Nuts</subject><subject>Prospective Studies</subject><subject>Protein sources</subject><subject>Risk</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>United States - 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Most evidence is derived from homogenous populations such as health professionals. Large community-based analyses in more diverse samples are lacking.
We studied the association of protein type and major dietary protein sources and risk for incident CHD in 12,066 middle-aged adults (aged 45-64 at baseline, 1987-1989) from four U.S. communities enrolled in the Atherosclerosis Risk in Communities (ARIC) Study who were free of diabetes mellitus and cardiovascular disease at baseline. Dietary protein intake was assessed at baseline and after 6 years of follow-up by food frequency questionnaire. Our primary outcome was adjudicated coronary heart disease events or deaths with following up through December 31, 2010. Cox proportional hazard models with multivariable adjustment were used for statistical analyses.
During a median follow-up of 22 years, there were 1,147 CHD events. In multivariable analyses total, animal and vegetable protein were not associated with an increased risk for CHD before or after adjustment. In food group analyses of major dietary protein sources, protein intake from red and processed meat, dairy products, fish, nuts, eggs, and legumes were not significantly associated with CHD risk. The hazard ratios [with 95% confidence intervals] for risk of CHD across quintiles of protein from poultry were 1.00 [ref], 0.83 [0.70-0.99], 0.93 [0.75-1.15], 0.88 [0.73-1.06], 0.79 [0.64-0.98], P for trend = 0.16). Replacement analyses evaluating the association of substituting one source of dietary protein for another or of decreasing protein intake at the expense of carbohydrates or total fats did not show any statistically significant association with CHD risk.
Based on a large community cohort we found no overall relationship between protein type and major dietary protein sources and risk for CHD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25303709</pmid><doi>10.1371/journal.pone.0109552</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adults Arteriosclerosis Atherosclerosis Biology and Life Sciences Carbohydrates Cardiovascular disease Cardiovascular diseases Cohort Studies Confidence intervals Coronary artery disease Coronary Disease - epidemiology Coronary Disease - etiology Dairy products Diabetes mellitus Diet Dietary intake Dietary Proteins - adverse effects Disease prevention Eggs Exercise Fats Female Food groups Health risk assessment Heart Heart diseases Humans Incidence Legumes Male Meat Medical personnel Medicine and Health Sciences Middle Aged Nutrition Surveys Nuts Prospective Studies Protein sources Risk Statistical analysis Statistical methods United States - epidemiology Womens health |
| title | Dietary protein intake and coronary heart disease in a large community based cohort: results from the Atherosclerosis Risk in Communities (ARIC) study [corrected] |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T11%3A46%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20protein%20intake%20and%20coronary%20heart%20disease%20in%20a%20large%20community%20based%20cohort:%20results%20from%20the%20Atherosclerosis%20Risk%20in%20Communities%20(ARIC)%20study%20%5Bcorrected%5D&rft.jtitle=PloS%20one&rft.au=Haring,%20Bernhard&rft.date=2014-10-10&rft.volume=9&rft.issue=10&rft.spage=e109552&rft.pages=e109552-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0109552&rft_dat=%3Cproquest_plos_%3E3457744501%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1610133523&rft_id=info:pmid/25303709&rft_doaj_id=oai_doaj_org_article_581bd17d6d654ecda6761d589c9ef43f&rfr_iscdi=true |