Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways

The obligate intracellular parasite, Toxoplasma gondii, disseminates through its host inside infected immune cells. We hypothesize that parasite nutrient requirements lead to manipulation of migratory properties of the immune cell. We demonstrate that 1) T. gondii relies on glutamine for optimal inf...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109803
Hauptverfasser:	Lee, I-Ping, Evans, Andrew K, Yang, Cissy, Works, Melissa G, Kumar, Vineet, De Miguel, Zurine, Manley, Nathan C, Sapolsky, Robert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport Systems - genetics Amino Acid Transport Systems - immunology Amino acids Animals Animals, Newborn Biology Biology and Life Sciences Bone marrow Bone Marrow Cells - immunology Bone Marrow Cells - parasitology Bone Marrow Cells - pathology CD80 antigen Cell adhesion & migration Cell Differentiation Cell growth Cell Movement - drug effects Chemokine CXCL12 - genetics Chemokine CXCL12 - immunology Chemokines CXCR4 protein Cytosol Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - parasitology Dendritic Cells - pathology Fibroblasts - immunology Fibroblasts - parasitology Fibroblasts - pathology Gene expression Gene Expression Regulation Genes, Reporter Glucose Glutamine Glutamine - metabolism Glutamine - pharmacology Health aspects Host-Pathogen Interactions Humans Immune system Infection Infections Kinases Leukocyte migration Lipopolysaccharides Lipopolysaccharides - pharmacology Luciferases - genetics Luciferases - metabolism Medicine Medicine and Health Sciences Neurosciences Neurosurgery Nutrient requirements Organisms, Genetically Modified Parasites Phenotypes Primary Cell Culture Proteins Rats Rats, Sprague-Dawley Receptors, CXCR4 - genetics Receptors, CXCR4 - immunology SDF-1 protein Signal Transduction Sodium Toxoplasma - genetics Toxoplasma - immunology Toxoplasma - metabolism Toxoplasma gondii Transport Viability
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