Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines

Lymphoblastoid cell lines (LCLs) are commonly used in molecular genetics, supplying DNA for the HapMap and 1000 Genomes Projects, used to test chemotherapeutic agents, and informing the basis of a number of population genetics studies of gene expression. The process of transforming human B cells int...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e108384
Hauptverfasser:	Houldcroft, Charlotte J, Petrova, Velislava, Liu, Jimmy Z, Frampton, Dan, Anderson, Carl A, Gall, Astrid, Kellam, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	B cells B-Lymphocytes - metabolism B-Lymphocytes - pathology B-Lymphocytes - virology Biology and life sciences Biotechnology Blood diseases Cell Line, Transformed Chemotherapy College campuses Copy number CXCL16 protein Cytokines Cytomegalovirus Deoxyribonucleic acid Disease DNA Epstein-Barr virus Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - immunology Epstein-Barr Virus Infections - virology Gene Dosage Gene expression Gene Expression Regulation Genes Genetic aspects Genetic control Genetic diversity Genetic research Genetic variance Genetic Variation Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Genotypes Herpesvirus 4, Human - genetics Herpesvirus 4, Human - immunology Humans Infections Lymphoblastoid cell lines Lymphocytes B Lymphoma Medicine and Health Sciences Phenotypes Polymorphism, Single Nucleotide Population genetics Population studies Quantitative Trait Loci Research and Analysis Methods Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Transcriptome Viruses
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