A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer

Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur in patients with non-small cell lung cancer (NSCLC). We investigated the kinetics of RT induced plasma inflammatory cytokines in these patients in order to identify clinical predictors of toxicity. In 12 NSCLC patients...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109560
Hauptverfasser:	Siva, Shankar, MacManus, Michael, Kron, Tomas, Best, Nickala, Smith, Jai, Lobachevsky, Pavel, Ball, David, Martin, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Analysis Biology Biomarkers Biomarkers - blood Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Chemokine CCL11 - blood Chemokine CCL11 - genetics Chemokine CCL2 - blood Chemokine CCL2 - genetics Chemokine CXCL10 - blood Chemokine CXCL10 - genetics Chemokines Chemoradiotherapy Chemotherapy Complications and side effects Cytokines Disease Eotaxin Experimental design Female Gamma Rays - adverse effects Gene Expression Growth factors Humans Inflammation Interleukin 6 Interleukin-6 - blood Interleukin-6 - genetics Ionizing radiation IP-10 protein Kinetics Laboratories Lung cancer Lung diseases Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Male Medical imaging Medical prognosis Medicine and Health Sciences Middle Aged Monocyte chemoattractant protein 1 Non-small cell lung cancer Non-small cell lung carcinoma Oncology Patients Plasma levels Pneumonia - blood Pneumonia - etiology Pneumonia - genetics Pneumonia - pathology Proteins Quality Radiation Radiation dosage Radiation effects Radiation Injuries - blood Radiation Injuries - genetics Radiation Injuries - pathology Radiation therapy Radiotherapy Dosage Rodents Small cell lung cancer Terminology Tissue inhibitor of metalloproteinase 1 Tissue Inhibitor of Metalloproteinase-1 - blood Tissue Inhibitor of Metalloproteinase-1 - genetics Toxicity Tumor necrosis factor-TNF Tumor necrosis factor-α Vascular endothelial growth factor
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