A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer
Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur in patients with non-small cell lung cancer (NSCLC). We investigated the kinetics of RT induced plasma inflammatory cytokines in these patients in order to identify clinical predictors of toxicity. In 12 NSCLC patients...
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| creator | Siva, Shankar MacManus, Michael Kron, Tomas Best, Nickala Smith, Jai Lobachevsky, Pavel Ball, David Martin, Olga |
| description | Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur in patients with non-small cell lung cancer (NSCLC). We investigated the kinetics of RT induced plasma inflammatory cytokines in these patients in order to identify clinical predictors of toxicity.
In 12 NSCLC patients, RT to 60 Gy (30 fractions over 6 weeks) was delivered; 6 received concurrent chemoradiation (chemoRT) and 6 received RT alone. Blood samples were taken before therapy, at 1 and 24 hours after delivery of the 1st fraction, 4 weeks into RT, and 12 weeks after completion of treatment, for analysis of a panel of 22 plasma cytokines. The severity of respiratory toxicities were recorded using common terminology criteria for adverse events (CTCAE) v4.0.
Twelve cytokines were detected in response to RT, of which ten demonstrated significant temporal changes in plasma concentration. For Eotaxin, IL-33, IL-6, MDC, MIP-1α and VEGF, plasma concentrations were dependent upon treatment group (chemoRT vs RT alone, all p-values |
| doi_str_mv | 10.1371/journal.pone.0109560 |
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In 12 NSCLC patients, RT to 60 Gy (30 fractions over 6 weeks) was delivered; 6 received concurrent chemoradiation (chemoRT) and 6 received RT alone. Blood samples were taken before therapy, at 1 and 24 hours after delivery of the 1st fraction, 4 weeks into RT, and 12 weeks after completion of treatment, for analysis of a panel of 22 plasma cytokines. The severity of respiratory toxicities were recorded using common terminology criteria for adverse events (CTCAE) v4.0.
Twelve cytokines were detected in response to RT, of which ten demonstrated significant temporal changes in plasma concentration. For Eotaxin, IL-33, IL-6, MDC, MIP-1α and VEGF, plasma concentrations were dependent upon treatment group (chemoRT vs RT alone, all p-values <0.05), whilst concentrations of MCP-1, IP-10, MCP-3, MIP-1β, TIMP-1 and TNF-α were not. Mean lung radiation dose correlated with a reduction at 1 hour in plasma levels of IP-10 (r2 = 0.858, p<0.01), MCP-1 (r2 = 0.653, p<0.01), MCP-3 (r2 = 0.721, p<0.01), and IL-6 (r2 = 0.531, p = 0.02). Patients who sustained pulmonary toxicity demonstrated significantly different levels of IP-10 and MCP-1 at 1 hour, and Eotaxin, IL-6 and TIMP-1 concentration at 24 hours (all p-values <0.05) when compared to patients without respiratory toxicity.
Inflammatory cytokines were induced in NSCLC patients during and after RT. Early changes in levels of IP-10, MCP-1, Eotaxin, IL-6 and TIMP-1 were associated with higher grade toxicity. Measurement of cytokine concentrations during RT could help predict lung toxicity and lead to new therapeutic strategies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0109560</identifier><identifier>PMID: 25289758</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Analysis ; Biology ; Biomarkers ; Biomarkers - blood ; Cancer ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - radiotherapy ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Chemokine CCL11 - blood ; Chemokine CCL11 - genetics ; Chemokine CCL2 - blood ; Chemokine CCL2 - genetics ; Chemokine CXCL10 - blood ; Chemokine CXCL10 - genetics ; Chemokines ; Chemoradiotherapy ; Chemotherapy ; Complications and side effects ; Cytokines ; Disease ; Eotaxin ; Experimental design ; Female ; Gamma Rays - adverse effects ; Gene Expression ; Growth factors ; Humans ; Inflammation ; Interleukin 6 ; Interleukin-6 - blood ; Interleukin-6 - genetics ; Ionizing radiation ; IP-10 protein ; Kinetics ; Laboratories ; Lung cancer ; Lung diseases ; Lung Neoplasms - pathology ; Lung Neoplasms - radiotherapy ; Male ; Medical imaging ; Medical prognosis ; Medicine and Health Sciences ; Middle Aged ; Monocyte chemoattractant protein 1 ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Oncology ; Patients ; Plasma levels ; Pneumonia - blood ; Pneumonia - etiology ; Pneumonia - genetics ; Pneumonia - pathology ; Proteins ; Quality ; Radiation ; Radiation dosage ; Radiation effects ; Radiation Injuries - blood ; Radiation Injuries - genetics ; Radiation Injuries - pathology ; Radiation therapy ; Radiotherapy Dosage ; Rodents ; Small cell lung cancer ; Terminology ; Tissue inhibitor of metalloproteinase 1 ; Tissue Inhibitor of Metalloproteinase-1 - blood ; Tissue Inhibitor of Metalloproteinase-1 - genetics ; Toxicity ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Vascular endothelial growth factor</subject><ispartof>PloS one, 2014-10, Vol.9 (10), p.e109560</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Siva et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Siva et al 2014 Siva et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b82a2396603144498596755136679dc890fefb4a1c54428bdfd4b6454b3689773</citedby><cites>FETCH-LOGICAL-c692t-b82a2396603144498596755136679dc890fefb4a1c54428bdfd4b6454b3689773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188745/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188745/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25289758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>LEE, Yong J.</contributor><creatorcontrib>Siva, Shankar</creatorcontrib><creatorcontrib>MacManus, Michael</creatorcontrib><creatorcontrib>Kron, Tomas</creatorcontrib><creatorcontrib>Best, Nickala</creatorcontrib><creatorcontrib>Smith, Jai</creatorcontrib><creatorcontrib>Lobachevsky, Pavel</creatorcontrib><creatorcontrib>Ball, David</creatorcontrib><creatorcontrib>Martin, Olga</creatorcontrib><title>A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur in patients with non-small cell lung cancer (NSCLC). We investigated the kinetics of RT induced plasma inflammatory cytokines in these patients in order to identify clinical predictors of toxicity.
In 12 NSCLC patients, RT to 60 Gy (30 fractions over 6 weeks) was delivered; 6 received concurrent chemoradiation (chemoRT) and 6 received RT alone. Blood samples were taken before therapy, at 1 and 24 hours after delivery of the 1st fraction, 4 weeks into RT, and 12 weeks after completion of treatment, for analysis of a panel of 22 plasma cytokines. The severity of respiratory toxicities were recorded using common terminology criteria for adverse events (CTCAE) v4.0.
Twelve cytokines were detected in response to RT, of which ten demonstrated significant temporal changes in plasma concentration. For Eotaxin, IL-33, IL-6, MDC, MIP-1α and VEGF, plasma concentrations were dependent upon treatment group (chemoRT vs RT alone, all p-values <0.05), whilst concentrations of MCP-1, IP-10, MCP-3, MIP-1β, TIMP-1 and TNF-α were not. Mean lung radiation dose correlated with a reduction at 1 hour in plasma levels of IP-10 (r2 = 0.858, p<0.01), MCP-1 (r2 = 0.653, p<0.01), MCP-3 (r2 = 0.721, p<0.01), and IL-6 (r2 = 0.531, p = 0.02). Patients who sustained pulmonary toxicity demonstrated significantly different levels of IP-10 and MCP-1 at 1 hour, and Eotaxin, IL-6 and TIMP-1 concentration at 24 hours (all p-values <0.05) when compared to patients without respiratory toxicity.
Inflammatory cytokines were induced in NSCLC patients during and after RT. Early changes in levels of IP-10, MCP-1, Eotaxin, IL-6 and TIMP-1 were associated with higher grade toxicity. Measurement of cytokine concentrations during RT could help predict lung toxicity and lead to new therapeutic strategies.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - radiotherapy</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Chemokine CCL11 - blood</subject><subject>Chemokine CCL11 - genetics</subject><subject>Chemokine CCL2 - blood</subject><subject>Chemokine CCL2 - genetics</subject><subject>Chemokine CXCL10 - blood</subject><subject>Chemokine CXCL10 - genetics</subject><subject>Chemokines</subject><subject>Chemoradiotherapy</subject><subject>Chemotherapy</subject><subject>Complications and side effects</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Eotaxin</subject><subject>Experimental design</subject><subject>Female</subject><subject>Gamma Rays - adverse effects</subject><subject>Gene Expression</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - genetics</subject><subject>Ionizing radiation</subject><subject>IP-10 protein</subject><subject>Kinetics</subject><subject>Laboratories</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Oncology</subject><subject>Patients</subject><subject>Plasma levels</subject><subject>Pneumonia - blood</subject><subject>Pneumonia - etiology</subject><subject>Pneumonia - genetics</subject><subject>Pneumonia - pathology</subject><subject>Proteins</subject><subject>Quality</subject><subject>Radiation</subject><subject>Radiation dosage</subject><subject>Radiation effects</subject><subject>Radiation Injuries - blood</subject><subject>Radiation Injuries - genetics</subject><subject>Radiation Injuries - pathology</subject><subject>Radiation therapy</subject><subject>Radiotherapy Dosage</subject><subject>Rodents</subject><subject>Small cell lung cancer</subject><subject>Terminology</subject><subject>Tissue inhibitor of metalloproteinase 1</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - blood</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - genetics</subject><subject>Toxicity</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Vascular endothelial growth factor</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk-2K1DAYhYso7rp6B6IBQfDHjEmbpMkfYVj8GFhY8OtvSNN0JmOazCapztyGV2xmp7tMQUEKbUmec963p3mL4jmCc1TV6O3GD8FJO996p-cQQU4ofFCcI16VM1rC6uHJ-1nxJMYNhKRilD4uzkpSMl4Tdl78XoCtTEkHB3wHtAx2D4JsjUzGu5lx7aB0C4zrrOx7mXzYA7VP_odxGujdNugYMwhMBDJGr7Iu479MWgM7uBVIfmeUSfvscKhjtEvxuO2yfeyltUDpfLullXRKh6fFo07aqJ-Nz4vi24f3Xy8_za6uPy4vF1czRXmZZg0rZVlxSmGFMMacEU5rQlBFac1bxTjsdNdgiRTBuGRN27W4oZjgpqL54-vqonh59N1aH8UYZxSIQo4gPBLLI9F6uRHbYHoZ9sJLI24XfFgJGZJRVota5kxRSZhSEpOWM624zO3kWhAp2mavd2O1oel1q3ISQdqJ6XTHmbVY-Z8CI8ZqTLLBq9Eg-JtBx_SPlkdqJXNX-b_5bKZ6E5VYZKcaMkRgpuZ_ofLV6t6ofKA6k9cngjcTQWaS3qWVHGIUyy-f_5-9_j5lX5-way1tWkdvh8Ppi1MQH0EVfIxBd_fJISgO83CXhjjMgxjnIctenKZ-L7obgOoP0yMHIg</recordid><startdate>20141007</startdate><enddate>20141007</enddate><creator>Siva, Shankar</creator><creator>MacManus, Michael</creator><creator>Kron, Tomas</creator><creator>Best, Nickala</creator><creator>Smith, Jai</creator><creator>Lobachevsky, Pavel</creator><creator>Ball, David</creator><creator>Martin, Olga</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141007</creationdate><title>A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer</title><author>Siva, Shankar ; MacManus, Michael ; Kron, Tomas ; Best, Nickala ; Smith, Jai ; Lobachevsky, Pavel ; Ball, David ; Martin, Olga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b82a2396603144498596755136679dc890fefb4a1c54428bdfd4b6454b3689773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biology</topic><topic>Biomarkers</topic><topic>Biomarkers - 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pathology</topic><topic>Radiation therapy</topic><topic>Radiotherapy Dosage</topic><topic>Rodents</topic><topic>Small cell lung cancer</topic><topic>Terminology</topic><topic>Tissue inhibitor of metalloproteinase 1</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - blood</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - genetics</topic><topic>Toxicity</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siva, Shankar</creatorcontrib><creatorcontrib>MacManus, Michael</creatorcontrib><creatorcontrib>Kron, Tomas</creatorcontrib><creatorcontrib>Best, Nickala</creatorcontrib><creatorcontrib>Smith, Jai</creatorcontrib><creatorcontrib>Lobachevsky, Pavel</creatorcontrib><creatorcontrib>Ball, David</creatorcontrib><creatorcontrib>Martin, Olga</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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We investigated the kinetics of RT induced plasma inflammatory cytokines in these patients in order to identify clinical predictors of toxicity.
In 12 NSCLC patients, RT to 60 Gy (30 fractions over 6 weeks) was delivered; 6 received concurrent chemoradiation (chemoRT) and 6 received RT alone. Blood samples were taken before therapy, at 1 and 24 hours after delivery of the 1st fraction, 4 weeks into RT, and 12 weeks after completion of treatment, for analysis of a panel of 22 plasma cytokines. The severity of respiratory toxicities were recorded using common terminology criteria for adverse events (CTCAE) v4.0.
Twelve cytokines were detected in response to RT, of which ten demonstrated significant temporal changes in plasma concentration. For Eotaxin, IL-33, IL-6, MDC, MIP-1α and VEGF, plasma concentrations were dependent upon treatment group (chemoRT vs RT alone, all p-values <0.05), whilst concentrations of MCP-1, IP-10, MCP-3, MIP-1β, TIMP-1 and TNF-α were not. Mean lung radiation dose correlated with a reduction at 1 hour in plasma levels of IP-10 (r2 = 0.858, p<0.01), MCP-1 (r2 = 0.653, p<0.01), MCP-3 (r2 = 0.721, p<0.01), and IL-6 (r2 = 0.531, p = 0.02). Patients who sustained pulmonary toxicity demonstrated significantly different levels of IP-10 and MCP-1 at 1 hour, and Eotaxin, IL-6 and TIMP-1 concentration at 24 hours (all p-values <0.05) when compared to patients without respiratory toxicity.
Inflammatory cytokines were induced in NSCLC patients during and after RT. Early changes in levels of IP-10, MCP-1, Eotaxin, IL-6 and TIMP-1 were associated with higher grade toxicity. Measurement of cytokine concentrations during RT could help predict lung toxicity and lead to new therapeutic strategies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25289758</pmid><doi>10.1371/journal.pone.0109560</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-10, Vol.9 (10), p.e109560 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1609100977 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Analysis Biology Biomarkers Biomarkers - blood Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Chemokine CCL11 - blood Chemokine CCL11 - genetics Chemokine CCL2 - blood Chemokine CCL2 - genetics Chemokine CXCL10 - blood Chemokine CXCL10 - genetics Chemokines Chemoradiotherapy Chemotherapy Complications and side effects Cytokines Disease Eotaxin Experimental design Female Gamma Rays - adverse effects Gene Expression Growth factors Humans Inflammation Interleukin 6 Interleukin-6 - blood Interleukin-6 - genetics Ionizing radiation IP-10 protein Kinetics Laboratories Lung cancer Lung diseases Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Male Medical imaging Medical prognosis Medicine and Health Sciences Middle Aged Monocyte chemoattractant protein 1 Non-small cell lung cancer Non-small cell lung carcinoma Oncology Patients Plasma levels Pneumonia - blood Pneumonia - etiology Pneumonia - genetics Pneumonia - pathology Proteins Quality Radiation Radiation dosage Radiation effects Radiation Injuries - blood Radiation Injuries - genetics Radiation Injuries - pathology Radiation therapy Radiotherapy Dosage Rodents Small cell lung cancer Terminology Tissue inhibitor of metalloproteinase 1 Tissue Inhibitor of Metalloproteinase-1 - blood Tissue Inhibitor of Metalloproteinase-1 - genetics Toxicity Tumor necrosis factor-TNF Tumor necrosis factor-α Vascular endothelial growth factor |
| title | A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer |
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