Validation of housekeeping genes in the brains of rats submitted to chronic intermittent hypoxia, a sleep apnea model

Obstructive sleep apnea (OSA) is a syndrome characterized by intermittent nocturnal hypoxia, sleep fragmentation, hypercapnia and respiratory effort, and it has been associated with several complications, such as diabetes, hypertension and obesity. Quantitative real-time PCR has been performed in pr...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109902-e109902
Hauptverfasser:	Julian, Guilherme Silva, de Oliveira, Renato Watanabe, Perry, Juliana Cini, Tufik, Sergio, Chagas, Jair Ribeiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - genetics Actins - metabolism Animal cognition Animals Apnea beta 2-Microglobulin - genetics beta 2-Microglobulin - metabolism Biology and Life Sciences Brain Brain - drug effects Brain - metabolism Brain Mapping Colorectal cancer Complications Computer programs Diabetes mellitus Disease Models, Animal Ethics Gene Expression Gene Expression Profiling Genes Genes, Essential Glyceraldehyde-3-phosphate dehydrogenase Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - genetics Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - metabolism Guanine Humans Hypercapnia Hypertension Hypoxanthine Hypoxanthine Phosphoribosyltransferase - genetics Hypoxanthine Phosphoribosyltransferase - metabolism Hypoxia Hypoxia - genetics Hypoxia - metabolism Hypoxia - pathology Laboratory animals Male Obesity Oxygen - pharmacology Phosphates Purines Rats Rats, Wistar Real-Time Polymerase Chain Reaction - standards Reference Standards RNA RNA, Ribosomal, 18S - genetics RNA, Ribosomal, 18S - metabolism Rodents rRNA 18S Sleep Sleep apnea Sleep Apnea, Obstructive - genetics Sleep Apnea, Obstructive - metabolism Sleep Apnea, Obstructive - pathology Sleep disorders Software Stability analysis Studies
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