Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels

Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke. Carboxylesterase 1 (CES1) is an enzyme that hydrolyzes triglycerides and cholesterol esters, and is important for lipid metabolism. Our pre...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109663
Hauptverfasser:	Xu, Jiesi, Yin, Liya, Xu, Yang, Li, Yuanyuan, Zalzala, Munaf, Cheng, Gang, Zhang, Yanqiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylation - drug effects Animal models Animals ATP Citrate (pro-S)-Lyase - metabolism ATP citrate lyase Biology and Life Sciences Blood Blood glucose Blood Glucose - metabolism Blood lipids Carboxylesterase Carboxylic Ester Hydrolases - metabolism Cardiovascular disease Cardiovascular diseases Cholesterol Chromatin Chromatin - metabolism Diabetes Diabetes mellitus Diet Dyslipidemia Enzymes Epigenetics Esters Fatty acids Gene expression Gene Expression Regulation, Enzymologic - drug effects Glucose Glucose - pharmacology Health risks Histones - metabolism Homeostasis Hyperglycemia Hypertension In vivo methods and tests Insulin Insulin resistance Kinases Lipid metabolism Lipids Liver Liver - enzymology Male Medicine and Health Sciences Metabolic disorders Metabolic syndrome Metabolism Mice Mice, Inbred C57BL Nutritional Status Obesity Overexpression Postprandial Period Rodents Triglycerides
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