Effects of single injection of local anesthetic agents on intervertebral disc degeneration: ex vivo and long-term in vivo experimental study

Analgesic discography (discoblock) can be used to diagnose or treat discogenic low back pain by injecting a small amount of local anesthetics. However, recent in vitro studies have revealed cytotoxic effects of local anesthetics on intervertebral disc (IVD) cells. Here we aimed to investigate the de...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109851
Hauptverfasser:	Iwasaki, Koji, Sudo, Hideki, Yamada, Katsuhisa, Higashi, Hideaki, Ohnishi, Takashi, Tsujimoto, Takeru, Iwasaki, Norimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Analgesics Anesthetics Anesthetics, Local - administration & dosage Anesthetics, Local - adverse effects Anesthetics, Local - therapeutic use Animals Apoptosis Back pain Bupivacaine Bupivacaine - administration & dosage Bupivacaine - adverse effects Bupivacaine - therapeutic use Cell culture Cell death Confocal microscopy Cytotoxicity Degeneration Drug dosages Experiments Feasibility studies Gene expression In vivo methods and tests Injection Injections Intervertebral Disc Degeneration - drug therapy Intervertebral discs Lidocaine Lidocaine - administration & dosage Lidocaine - adverse effects Lidocaine - therapeutic use Local anesthesia Local anesthetics Low back pain Magnetic resonance Magnetic resonance imaging Medicine Medicine and Health Sciences Microscopy Nuclei Nuclei (cytology) Nucleus pulposus Organ Culture Techniques Pain Rabbits Saline solutions Surgery Time Factors University graduates Vertebra Vertebrae
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