The gene expression response of chronic lymphocytic leukemia cells to IL-4 is specific, depends on ZAP-70 status and is differentially affected by an NFκB inhibitor

Interleukin 4 (IL-4), an essential mediator of B cell development, plays a role in survival of chronic lymphocytic leukemia (CLL) cells. To obtain new insights into the function of the IL-4 pathway in CLL, we analyzed the gene expression response to IL-4 in CLL and in normal B cells (NBC) by oligonu...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109533-e109533
Hauptverfasser:	Ruiz-Lafuente, Natalia, Alcaraz-García, María-José, Sebastián-Ruiz, Silvia, Gómez-Espuch, Joaquín, Funes, Consuelo, Moraleda, José-María, García-Garay, María-Carmen, Montes-Barqueros, Natividad, Minguela, Alfredo, Álvarez-López, María-Rocío, Parrado, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Apoptosis Bcl-6 protein Biology and Life Sciences Biomarkers, Tumor - genetics Blotting, Western Cancer Case-Control Studies CC chemokine receptors CCR2 protein Cell Proliferation Cell survival Cells, Cultured Chronic lymphatic leukemia Chronic lymphocytic leukemia Correlation Cytokines DNA microarrays Gene expression Gene Expression Profiling Genes Humans I-kappa B Proteins - genetics Inhibitors Interleukin Interleukin 4 Interleukin-4 - pharmacology Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphatic leukemia Lymphocyte receptors Lymphocytes Lymphocytes - cytology Lymphocytes - metabolism Lymphocytes B Lymphoma Lymphomas Medical prognosis Medicine and Health Sciences Monocyte chemoattractant protein 1 Mutation NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-κB protein Oligonucleotide Array Sequence Analysis Oligonucleotides Pathogenesis Real-Time Polymerase Chain Reaction Research and Analysis Methods Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics ZAP-70 protein ZAP-70 Protein-Tyrosine Kinase - genetics
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Zusammenfassung:	Interleukin 4 (IL-4), an essential mediator of B cell development, plays a role in survival of chronic lymphocytic leukemia (CLL) cells. To obtain new insights into the function of the IL-4 pathway in CLL, we analyzed the gene expression response to IL-4 in CLL and in normal B cells (NBC) by oligonucleotide microarrays, resulting in the identification of 232 non-redundant entities in CLL and 146 in NBC (95 common, 283 altogether), of which 189 were well-defined genes in CLL and 123 in NBC (83 common, 229 altogether) (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0109533