Characterization of programmed death-1 homologue-1 (PD-1H) expression and function in normal and HIV infected individuals

Chronic immune activation that persists despite anti-retroviral therapy (ART) is the strongest predictor of disease progression in HIV infection. Monocyte/macrophages in HIV-infected individuals are known to spontaneously secrete cytokines, although neither the mechanism nor the molecules involved a...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109103-e109103
Hauptverfasser:	Bharaj, Preeti, Chahar, Harendra Singh, Alozie, Ogechika K, Rodarte, Lizette, Bansal, Anju, Goepfert, Paul A, Dwivedi, Alok, Manjunath, N, Shankar, Premlata
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Antigen presentation Apoptosis B cells B7 Antigens - metabolism Biology and Life Sciences CD4 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell activation Chemical properties Clonal deletion Cytokines Cytokines - metabolism Development and progression Evaluation Health aspects HIV HIV infections HIV Infections - immunology HIV Infections - metabolism HIV patients Homology Human immunodeficiency virus Humans Immune response Immune system Infection Infections Kinases Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Macrophages - metabolism Monocytes Monocytes - immunology Monocytes - metabolism PD-1 protein Signaling T cell receptors T cells Viral Load - immunology
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