Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese

To examine whether GNAQ and GNA11 somatic mutations previously identified in uveal melanomas of Caucasians are associated with uveal melanomas in Chinese patients. Uveal melanomas treated by primary enucleation in Chinese patients underwent a mutation analysis of GNAQ and GNA11 with sequencing of ex...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109699-e109699
Hauptverfasser:	Xu, Xiaolin, Wei, Wen Bin, Li, Bin, Gao, Fei, Zhang, Zhibao, Jonas, Jost B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Asian Continental Ancestry Group - genetics Binding sites Biology and Life Sciences Deoxyribonucleic acid DNA DNA Mutational Analysis Enucleation Female Follow-Up Studies Genetic aspects GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits, Gq-G11 Humans Kinases Laboratories Male Medicine and Health Sciences Melanoma Melanoma - genetics Melanoma - mortality Melanoma - pathology Metastases Metastasis Middle Aged Mutation Mutation - genetics Neoplasm Staging Patients Prognosis Proteins Skin cancer Survival Rate Tumors Uveal Neoplasms - genetics Uveal Neoplasms - mortality Uveal Neoplasms - pathology Young Adult
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