PSMA-specific CAR-engineered T cells eradicate disseminated prostate cancer in preclinical models

Immunology-based interventions have been proposed as a promising curative chance to effectively attack postoperative minimal residual disease and distant metastatic localizations of prostate tumors. We developed a chimeric antigen receptor (CAR) construct targeting the human prostate-specific membra...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109427-e109427
Hauptverfasser:	Zuccolotto, Gaia, Fracasso, Giulio, Merlo, Anna, Montagner, Isabella Monia, Rondina, Maria, Bobisse, Sara, Figini, Mariangela, Cingarlini, Sara, Colombatti, Marco, Zanovello, Paola, Rosato, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Animal models Animals Antigens Antigens, Surface - immunology Apoptosis B cells Biology and Life Sciences Blotting, Western Cancer therapies Cell Proliferation Chimeric antigen receptors Cytokines Cytotoxicity Expression vectors Flow Cytometry Gastroenterology Gene expression Genetic engineering Genetic Vectors Glutamate Carboxypeptidase II - immunology Hematology Humans Immunology Immunotherapy, Adoptive Leukemia Leukocytes, Mononuclear - immunology Lymphocytes Lymphocytes T Male Medicine and Health Sciences Metastases Mice Mice, Inbred NOD Mice, SCID Minimal residual disease Oncology Peripheral blood mononuclear cells Prostate cancer Prostatic Neoplasms - immunology Prostatic Neoplasms - prevention & control Prostatic Neoplasms - secondary Protein Engineering Receptors, Antigen, T-Cell - immunology Reporter gene Signal transduction Surgery T cell receptors T cells T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - transplantation Transgenic Tumor cells Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays
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