Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population
It has been reported that IKAROS family of zinc finger 3 (IKZF3)-deficient mice spontaneously develop human systemic lupus erythematosus (SLE)-like phenotypes and produce anti-dsDNA Ab leading to immune complex-mediated glomerulonephritis. Polymorphism of the IKZF3 gene corresponds with the suscepti...
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| creator | Cai, Xinze Qiao, Ying Diao, Cheng Xu, Xiaoxue Chen, Yang Du, Shuyan Liu, Xudong Liu, Nan Yu, Shuang Chen, Dong Jiang, Yi |
| description | It has been reported that IKAROS family of zinc finger 3 (IKZF3)-deficient mice spontaneously develop human systemic lupus erythematosus (SLE)-like phenotypes and produce anti-dsDNA Ab leading to immune complex-mediated glomerulonephritis. Polymorphism of the IKZF3 gene corresponds with the susceptibility to several immune-related diseases. Our intention was to establish an association between polymorphisms in the IKZF3 gene and SLE in the Chinese Han population.
The study involved obtaining blood samples for DNA extraction and genotyping the 4 selected single-nucleotide polymorphisms (SNPs) in IKZF3, including rs12150079, rs9909593, rs907091, and rs2872507, by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP). A group of 366 SLE patients were compared to 455 healthy controls.
A significant decrease in frequencies of the rs907091 CC genotype and C allele appeared in the SLE patients unlike that observed in the controls (p = 0.001 and 0.015, respectively). The frequencies of the rs12150079 genotype and allele were different between the SLE patients and the control individuals, although the significance was only marginal (p = 0.046 and 0.049, respectively). In addition, a significantly low frequency of the GGCG haplotype was observed in the SLE patients, suggesting that it may provide protection against SLE (p = 0.011).
To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IKZF3 and SLE in the Chinese Han population. A strong association between rs907091 in the IKZF3 gene and SLE was identified. |
| doi_str_mv | 10.1371/journal.pone.0108661 |
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The study involved obtaining blood samples for DNA extraction and genotyping the 4 selected single-nucleotide polymorphisms (SNPs) in IKZF3, including rs12150079, rs9909593, rs907091, and rs2872507, by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP). A group of 366 SLE patients were compared to 455 healthy controls.
A significant decrease in frequencies of the rs907091 CC genotype and C allele appeared in the SLE patients unlike that observed in the controls (p = 0.001 and 0.015, respectively). The frequencies of the rs12150079 genotype and allele were different between the SLE patients and the control individuals, although the significance was only marginal (p = 0.046 and 0.049, respectively). In addition, a significantly low frequency of the GGCG haplotype was observed in the SLE patients, suggesting that it may provide protection against SLE (p = 0.011).
To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IKZF3 and SLE in the Chinese Han population. A strong association between rs907091 in the IKZF3 gene and SLE was identified.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0108661</identifier><identifier>PMID: 25271777</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alleles ; Anti-DNA antibodies ; Arthritis ; Asian Continental Ancestry Group - genetics ; Asthma ; Autoimmune diseases ; Bioinformatics ; Biology and Life Sciences ; Case-Control Studies ; China ; Chronic conditions ; Deoxyribonucleic acid ; Disease ; DNA ; Gene Frequency ; Gene polymorphism ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Genotyping ; Glomerulonephritis ; Haplotypes ; Hospitals ; Humans ; Ikaros protein ; Ikaros Transcription Factor - genetics ; Immunology ; Laboratories ; Lupus ; Lupus Erythematosus, Systemic - genetics ; Medicine and Health Sciences ; Motivation ; Patients ; Polymerase chain reaction ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Population ; Population studies ; Restriction fragment length polymorphism ; Single-nucleotide polymorphism ; Systemic lupus erythematosus ; Tumor necrosis factor-TNF ; Zinc ; Zinc finger proteins</subject><ispartof>PloS one, 2014-10, Vol.9 (10), p.e108661-e108661</ispartof><rights>2014 Cai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Cai et al 2014 Cai et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-d3b2a66869de15118ce22a043bb974b1ffaa888d4f5789ff26a526de89e8efd03</citedby><cites>FETCH-LOGICAL-c592t-d3b2a66869de15118ce22a043bb974b1ffaa888d4f5789ff26a526de89e8efd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182708/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182708/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25271777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rieux-Laucat, Frederic</contributor><creatorcontrib>Cai, Xinze</creatorcontrib><creatorcontrib>Qiao, Ying</creatorcontrib><creatorcontrib>Diao, Cheng</creatorcontrib><creatorcontrib>Xu, Xiaoxue</creatorcontrib><creatorcontrib>Chen, Yang</creatorcontrib><creatorcontrib>Du, Shuyan</creatorcontrib><creatorcontrib>Liu, Xudong</creatorcontrib><creatorcontrib>Liu, Nan</creatorcontrib><creatorcontrib>Yu, Shuang</creatorcontrib><creatorcontrib>Chen, Dong</creatorcontrib><creatorcontrib>Jiang, Yi</creatorcontrib><title>Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>It has been reported that IKAROS family of zinc finger 3 (IKZF3)-deficient mice spontaneously develop human systemic lupus erythematosus (SLE)-like phenotypes and produce anti-dsDNA Ab leading to immune complex-mediated glomerulonephritis. Polymorphism of the IKZF3 gene corresponds with the susceptibility to several immune-related diseases. Our intention was to establish an association between polymorphisms in the IKZF3 gene and SLE in the Chinese Han population.
The study involved obtaining blood samples for DNA extraction and genotyping the 4 selected single-nucleotide polymorphisms (SNPs) in IKZF3, including rs12150079, rs9909593, rs907091, and rs2872507, by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP). A group of 366 SLE patients were compared to 455 healthy controls.
A significant decrease in frequencies of the rs907091 CC genotype and C allele appeared in the SLE patients unlike that observed in the controls (p = 0.001 and 0.015, respectively). The frequencies of the rs12150079 genotype and allele were different between the SLE patients and the control individuals, although the significance was only marginal (p = 0.046 and 0.049, respectively). In addition, a significantly low frequency of the GGCG haplotype was observed in the SLE patients, suggesting that it may provide protection against SLE (p = 0.011).
To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IKZF3 and SLE in the Chinese Han population. A strong association between rs907091 in the IKZF3 gene and SLE was identified.</description><subject>Alleles</subject><subject>Anti-DNA antibodies</subject><subject>Arthritis</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Asthma</subject><subject>Autoimmune diseases</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Chronic conditions</subject><subject>Deoxyribonucleic acid</subject><subject>Disease</subject><subject>DNA</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Glomerulonephritis</subject><subject>Haplotypes</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Ikaros protein</subject><subject>Ikaros Transcription Factor - genetics</subject><subject>Immunology</subject><subject>Laboratories</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Medicine and Health Sciences</subject><subject>Motivation</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Population studies</subject><subject>Restriction fragment length polymorphism</subject><subject>Single-nucleotide polymorphism</subject><subject>Systemic lupus erythematosus</subject><subject>Tumor necrosis factor-TNF</subject><subject>Zinc</subject><subject>Zinc finger proteins</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptkstu1DAUhiMEoqXlDRBYYsNmBt9iOxukakTpiErd0A0by0lOZjxy7GAnRfP2eDpp1aKufPvPdy7-i-IDwUvCJPm6C1P0xi2H4GGJCVZCkFfFKakYXQiK2esn-5PiXUo7jEuWVW-LE1pSSaSUp8VwkVJorBlt8KiG8S-AR0Nw-z7EYWtTn1Do0LgFtP75-5KhDXhAxrco7dMIvW2Qm4YpIYj7LOrNGFI-WY8MWm2thwToyhyIw-Tuk5wXbzrjEryf17Pi9vL7r9XV4vrmx3p1cb1oyoqOi5bV1AihRNUCKQlRDVBqMGd1XUlek64zRinV8q6Uquo6KkxJRQuqAgVdi9lZ8enIHVxIeh5W0qTMUMoYZ1mxPiraYHZ6iLY3ca-Dsfr-IsSNNnG0jQOdB9dQKGtV5UhKpJI1bhlwbmpOJK8y69ucbap7aBvwYzTuGfT5i7dbvQl3mhNFJVYZ8GUGxPBngjTq3qYGnDMewnSoWwmC8zeLLP38n_Tl7vhR1cSQUoTusRiC9cFAD1H6YCA9GyiHfXzayGPQg2PYPxDIxRk</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Cai, Xinze</creator><creator>Qiao, Ying</creator><creator>Diao, Cheng</creator><creator>Xu, Xiaoxue</creator><creator>Chen, Yang</creator><creator>Du, Shuyan</creator><creator>Liu, Xudong</creator><creator>Liu, Nan</creator><creator>Yu, Shuang</creator><creator>Chen, Dong</creator><creator>Jiang, Yi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141001</creationdate><title>Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population</title><author>Cai, Xinze ; Qiao, Ying ; Diao, Cheng ; Xu, Xiaoxue ; Chen, Yang ; Du, Shuyan ; Liu, Xudong ; Liu, Nan ; Yu, Shuang ; Chen, Dong ; Jiang, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-d3b2a66869de15118ce22a043bb974b1ffaa888d4f5789ff26a526de89e8efd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alleles</topic><topic>Anti-DNA antibodies</topic><topic>Arthritis</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Asthma</topic><topic>Autoimmune diseases</topic><topic>Bioinformatics</topic><topic>Biology and Life Sciences</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Chronic conditions</topic><topic>Deoxyribonucleic acid</topic><topic>Disease</topic><topic>DNA</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotyping</topic><topic>Glomerulonephritis</topic><topic>Haplotypes</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Ikaros protein</topic><topic>Ikaros Transcription Factor - genetics</topic><topic>Immunology</topic><topic>Laboratories</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - genetics</topic><topic>Medicine and Health Sciences</topic><topic>Motivation</topic><topic>Patients</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Population studies</topic><topic>Restriction fragment length polymorphism</topic><topic>Single-nucleotide polymorphism</topic><topic>Systemic lupus erythematosus</topic><topic>Tumor necrosis factor-TNF</topic><topic>Zinc</topic><topic>Zinc finger proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Xinze</creatorcontrib><creatorcontrib>Qiao, Ying</creatorcontrib><creatorcontrib>Diao, Cheng</creatorcontrib><creatorcontrib>Xu, Xiaoxue</creatorcontrib><creatorcontrib>Chen, Yang</creatorcontrib><creatorcontrib>Du, Shuyan</creatorcontrib><creatorcontrib>Liu, Xudong</creatorcontrib><creatorcontrib>Liu, Nan</creatorcontrib><creatorcontrib>Yu, Shuang</creatorcontrib><creatorcontrib>Chen, Dong</creatorcontrib><creatorcontrib>Jiang, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Xinze</au><au>Qiao, Ying</au><au>Diao, Cheng</au><au>Xu, Xiaoxue</au><au>Chen, Yang</au><au>Du, Shuyan</au><au>Liu, Xudong</au><au>Liu, Nan</au><au>Yu, Shuang</au><au>Chen, Dong</au><au>Jiang, Yi</au><au>Rieux-Laucat, Frederic</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>9</volume><issue>10</issue><spage>e108661</spage><epage>e108661</epage><pages>e108661-e108661</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>It has been reported that IKAROS family of zinc finger 3 (IKZF3)-deficient mice spontaneously develop human systemic lupus erythematosus (SLE)-like phenotypes and produce anti-dsDNA Ab leading to immune complex-mediated glomerulonephritis. Polymorphism of the IKZF3 gene corresponds with the susceptibility to several immune-related diseases. Our intention was to establish an association between polymorphisms in the IKZF3 gene and SLE in the Chinese Han population.
The study involved obtaining blood samples for DNA extraction and genotyping the 4 selected single-nucleotide polymorphisms (SNPs) in IKZF3, including rs12150079, rs9909593, rs907091, and rs2872507, by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP). A group of 366 SLE patients were compared to 455 healthy controls.
A significant decrease in frequencies of the rs907091 CC genotype and C allele appeared in the SLE patients unlike that observed in the controls (p = 0.001 and 0.015, respectively). The frequencies of the rs12150079 genotype and allele were different between the SLE patients and the control individuals, although the significance was only marginal (p = 0.046 and 0.049, respectively). In addition, a significantly low frequency of the GGCG haplotype was observed in the SLE patients, suggesting that it may provide protection against SLE (p = 0.011).
To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IKZF3 and SLE in the Chinese Han population. A strong association between rs907091 in the IKZF3 gene and SLE was identified.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25271777</pmid><doi>10.1371/journal.pone.0108661</doi><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alleles Anti-DNA antibodies Arthritis Asian Continental Ancestry Group - genetics Asthma Autoimmune diseases Bioinformatics Biology and Life Sciences Case-Control Studies China Chronic conditions Deoxyribonucleic acid Disease DNA Gene Frequency Gene polymorphism Genetic Association Studies Genetic Predisposition to Disease Genotype Genotyping Glomerulonephritis Haplotypes Hospitals Humans Ikaros protein Ikaros Transcription Factor - genetics Immunology Laboratories Lupus Lupus Erythematosus, Systemic - genetics Medicine and Health Sciences Motivation Patients Polymerase chain reaction Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide Population Population studies Restriction fragment length polymorphism Single-nucleotide polymorphism Systemic lupus erythematosus Tumor necrosis factor-TNF Zinc Zinc finger proteins |
| title | Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T02%3A51%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20polymorphisms%20of%20the%20IKZF3%20gene%20and%20systemic%20lupus%20erythematosus%20in%20a%20Chinese%20Han%20population&rft.jtitle=PloS%20one&rft.au=Cai,%20Xinze&rft.date=2014-10-01&rft.volume=9&rft.issue=10&rft.spage=e108661&rft.epage=e108661&rft.pages=e108661-e108661&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0108661&rft_dat=%3Cproquest_plos_%3E3449158651%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1566823343&rft_id=info:pmid/25271777&rft_doaj_id=oai_doaj_org_article_053c2e5b8933421787b0d3e44ab41749&rfr_iscdi=true |