Androgen suppresses the proliferation of androgen receptor-positive castration-resistant prostate cancer cells via inhibition of Cdk2, CyclinA, and Skp2

The majority of prostate cancer (PCa) patient receiving androgen ablation therapy eventually develop castration-resistant prostate cancer (CRPC). We previously reported that androgen treatment suppresses Skp2 and c-Myc through androgen receptor (AR) and induced G1 cell cycle arrest in androgen-indep...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10), p.e109170
Hauptverfasser:	Kokontis, John M, Lin, Hui-Ping, Jiang, Shih Sheng, Lin, Ching-Yu, Fukuchi, Junichi, Hiipakka, Richard A, Chung, Chi-Jung, Chan, Tzu-Min, Liao, Shutsung, Chang, Chung-Ho, Chuu, Chih-Pin
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptors Androgens Androgens - physiology Biology and Life Sciences c-Myc protein Cancer Castration Cell culture Cell cycle Cell Line, Tumor Cell proliferation Cell Proliferation - physiology Cyclin A Cyclin A - antagonists & inhibitors Cyclin-dependent kinase 2 Cyclin-Dependent Kinase 2 - antagonists & inhibitors Cyclin-dependent kinase inhibitor p27 Cyclin-dependent kinases E2F1 protein Gene expression Humans Inhibition Kinases Male Medical research Medicine and Health Sciences Myc protein Orchiectomy Phosphorylation Prostate cancer Prostatic Neoplasms - pathology S-Phase Kinase-Associated Proteins - antagonists & inhibitors Skp2 protein
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