Withaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cells

Currently, the treatment for ovarian cancer entails cytoreductive surgery followed by chemotherapy, mainly, carboplatin combined with paclitaxel. Although this regimen is initially effective in a high percentage of cases, unfortunately within few months of initial treatment, tumor relapse occurs bec...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e107596
Hauptverfasser:	Kakar, Sham S, Ratajczak, Mariusz Z, Powell, Karen S, Moghadamfalahi, Mana, Miller, Donald M, Batra, Surinder K, Singh, Sanjay K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioactive compounds Biology and Life Sciences Biomarkers Biomarkers, Tumor - metabolism Biophysics Breast cancer Cancer Carboplatin Carcinoma, Ovarian Epithelial CD34 antigen CD44 antigen Cell cycle Cell Division - drug effects Cell Line, Tumor Chemotherapy Cisplatin Cisplatin - administration & dosage Cisplatin - pharmacology Deoxyribonucleic acid DNA Drug resistance Female Gene expression Humans Lupus Medical prognosis Medicine and Health Sciences Metastases Metastasis Mice Mice, Nude Neoplasm Metastasis - prevention & control Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Notch1 protein Oct-4 protein Organs Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Paclitaxel Physiology Platinum Signal transduction Signaling Stem cell transplantation Stem cells Surgery Tumors Withanolides - administration & dosage Withanolides - pharmacology Womens health
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