Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolic pathway which catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate donates methyl group for the methylation of homocysteine to methionine. Several...

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Veröffentlicht in:	PloS one 2014, Vol.9 (9), p.e108552-e108552
Hauptverfasser:	Rai, Vandana, Yadav, Upendra, Kumar, Pradeep, Yadav, Sushil Kumar, Mishra, Om Prakesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Bias Biology and Life Sciences Biotechnology Chromosomes Confidence intervals Defects Deoxyribonucleic acid DNA DNA methylation Down syndrome Down Syndrome - epidemiology Down Syndrome - genetics Down's syndrome Female Folic acid Gene polymorphism Genes Genetic Association Studies Genetic Predisposition to Disease Genetics Homocysteine Humans Laboratories Medical ethics Medicine and Health Sciences Meta-analysis Metabolism Methionine Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Polymorphism Polymorphism, Single Nucleotide Pregnancy Risk Risk analysis Risk assessment Risk Factors Scientific papers Search engines Studies Vitamin B Vitamin deficiency
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