PRO-C3-levels in patients with HIV/HCV-Co-infection reflect fibrosis stage and degree of portal hypertension

Liver-related deaths represent the leading cause of mortality among patients with HIV/HCV-co-infection, and are mainly related to complications of fibrosis and portal hypertension. In this study, we aimed to evaluate the structural changes by the assessment of extracellular matrix (ECM) derived degr...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e108544-e108544
Hauptverfasser:	Jansen, Christian, Leeming, Diana J, Mandorfer, Mattias, Byrjalsen, Inger, Schierwagen, Robert, Schwabl, Philipp, Karsdal, Morten A, Anadol, Evrim, Strassburg, Christian P, Rockstroh, Jürgen, Peck-Radosavljevic, Markus, Møller, Søren, Bendtsen, Flemming, Krag, Aleksander, Reiberger, Thomas, Trebicka, Jonel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Alanine Alanine transaminase Alanine Transaminase - blood Biology Biomarkers Blood Coinfection - blood Coinfection - immunology Collagen Collagen (type III) Collagen (type IV) Collagen (type V) Complement C3 - immunology Complement C4 - immunology Complement C5 - immunology Complications Degradation Disease control Enzymes Extracellular matrix Extracellular Matrix - pathology Female Fibrosis Gastroenterology Gelatinase A Hepatitis C, Chronic - blood Hepatitis C, Chronic - immunology Hepatology HIV HIV Infections - blood HIV Infections - immunology Hospitals Human immunodeficiency virus Humans Hypertension Hypertension, Portal Infections Internal medicine Legal medicine Liver Liver - injuries Liver Cirrhosis - blood Liver Cirrhosis - immunology Liver diseases Male Medicine Medicine and health sciences Middle Aged Mortality Patients Peripheral blood Portal Pressure Retrospective Studies Young Adult
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