Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability

Vascular calcification, recapitulating bone formation, has a profound impact on plaque stability. The aim of the present study was to determine the influence of bone-like vascular calcification (named osteoid metaplasia = OM) and of osteoprotegerin on plaque stability. Tissue from carotid endarterec...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e107642-e107642
Hauptverfasser:	Davaine, Jean-Michel, Quillard, Thibaut, Brion, Régis, Lapérine, Olivier, Guyomarch, Béatrice, Merlini, Thierry, Chatelais, Mathias, Guilbaud, Florian, Brennan, Meadhbh Áine, Charrier, Céline, Heymann, Dominique, Gouëffic, Yann, Heymann, Marie-Françoise
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Biocompatibility Biology and Life Sciences Biomedical materials Bone growth Bones Calcification Calcification (ectopic) Cardiovascular disease Carotid Stenosis - diagnosis Carotid Stenosis - metabolism Carotid Stenosis - pathology CD14 antigen CD146 Antigen - metabolism Cell Differentiation Computed tomography Cytokines Differentiation Endothelial cells Evaluation Family medical history Histochemistry Homeostasis Humans Ligands Magnetic resonance imaging Medicine and Health Sciences Metaplasia Mineralization Mortality Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteoclastogenesis Osteoclasts Osteogenesis Osteoid Osteoprotegerin Osteoprotegerin - blood Osteoprotegerin - metabolism Patients Pericytes Pericytes - cytology Pericytes - metabolism Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Plaques RANK Ligand - metabolism Rodents Stability analysis Stroke Studies Surgery Tumor necrosis factor-TNF Vascular Calcification
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