Targeted mutagenesis in Atlantic salmon (Salmo salar L.) using the CRISPR/Cas9 system induces complete knockout individuals in the F0 generation

Understanding the biological function behind key proteins is of great concern in Atlantic salmon, both due to a high commercial importance and an interesting life history. Until recently, functional studies in salmonids appeared to be difficult. However, the recent discovery of targeted mutagenesis...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e108622
Hauptverfasser:	Edvardsen, Rolf B, Leininger, Sven, Kleppe, Lene, Skaftnesmo, Kai Ove, Wargelius, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Assaying Biology and Life Sciences Cold water CRISPR CRISPR-Cas Systems Embryonic development Embryos Fish Fishes Gene Knockout Techniques Gene Targeting - methods Genes Hatching Juveniles Laridae Life history Marine technology Mosaicism Mutagenesis Mutation Mutation Rate Mutation rates Oncorhynchus mykiss Phenotype Phenotypic variations Pigmentation Pigments Proteins Salmo salar Salmo salar - genetics Salmon Salmonidae Salmonids Site-directed mutagenesis Spots Targeted mutagenesis Tyrosinase Xenopus Zebrafish
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