Development of a fatal noncompressible truncal hemorrhage model with combined hepatic and portal venous injury in normothermic normovolemic swine
Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatme...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-09, Vol.9 (9), p.e108293-e108293 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e108293 |
|---|---|
| container_issue | 9 |
| container_start_page | e108293 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Yanala, Ujwal R Johanning, Jason M Pipinos, Iraklis I Larsen, Gustavo Velander, William H Carlson, Mark A |
| description | Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ∼ 50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34-36 kg) underwent one of three injury types through a midline incision: 1) central stellate injury (N = 6); 2) excision of a portal vein branch distal to the main PV trunk (N = 6); or 3) hemi-transection of the left lateral lobe of the liver at its base (N = 10). The one-hour mortality of these injuries was 0, 82, and 40%, respectively; the final mean arterial pressure was 65, 24, and 30 mm Hg, respectively; and the final hemoglobin was 8.3, 2.3, and 3.6 g/dL, respectively. Hemi-transection of the left lateral lobe of the liver appeared to target our desired mortality rate better than the other injury mechanisms. |
| doi_str_mv | 10.1371/journal.pone.0108293 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1564617586</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_1d1ee835c216433a9d2124ea28960b02</doaj_id><sourcerecordid>1566826009</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-e63145d868f6f3feba8412f8b535326ee709447d7fdb6734994c7ee76a5cc2663</originalsourceid><addsrcrecordid>eNptks1u1DAQxyMEoqXwBggsceGyi7-TXJBQoaVSJS5wthx7ssnKsYOdbNXH4I1xumnVIk7jmfnPzzOjKYq3BG8JK8mnfZij1247Bg9bTHBFa_asOCU1oxtJMXv-6H1SvEppj7FglZQvixMqqCAck9Piz1c4gAvjAH5CoUUatXrSDvngTRjGCCn1jQM0xdmbHO9gCDF2egdoCBYcuumnDmVp03uwOT3qqTdIe4vGEBfSAXyYE-r9fo632WR0HMLUQRyy8M45BAeLk24y5HXxotUuwZvVnhW_Lr79PP--uf5xeXX-5XpjBJXTBiQjXNhKVq1sWQuNrjihbdUIJhiVACWuOS9t2dpGlozXNTdljkotjKFSsrPi_ZE7upDUus2kiJBcklJUi-LqqLBB79UY-0HHWxV0r-4CIe6UjnlaB4pYAlAxYSiRnDFdW0ooB02rWuIG08z6vP42NwNYk9cdtXsCfZrxfad24aA4KWUt6wz4uAJi-D1DmtTQJwPOaQ95v0vfsqIS40X64R_p_6fjR5WJIaUI7UMzBKvlwu6r1HJhar2wXPbu8SAPRfcnxf4CDULSZQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1564617586</pqid></control><display><type>article</type><title>Development of a fatal noncompressible truncal hemorrhage model with combined hepatic and portal venous injury in normothermic normovolemic swine</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Yanala, Ujwal R ; Johanning, Jason M ; Pipinos, Iraklis I ; Larsen, Gustavo ; Velander, William H ; Carlson, Mark A</creator><contributor>Raju, Raghavan</contributor><creatorcontrib>Yanala, Ujwal R ; Johanning, Jason M ; Pipinos, Iraklis I ; Larsen, Gustavo ; Velander, William H ; Carlson, Mark A ; Raju, Raghavan</creatorcontrib><description>Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ∼ 50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34-36 kg) underwent one of three injury types through a midline incision: 1) central stellate injury (N = 6); 2) excision of a portal vein branch distal to the main PV trunk (N = 6); or 3) hemi-transection of the left lateral lobe of the liver at its base (N = 10). The one-hour mortality of these injuries was 0, 82, and 40%, respectively; the final mean arterial pressure was 65, 24, and 30 mm Hg, respectively; and the final hemoglobin was 8.3, 2.3, and 3.6 g/dL, respectively. Hemi-transection of the left lateral lobe of the liver appeared to target our desired mortality rate better than the other injury mechanisms.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0108293</identifier><identifier>PMID: 25251401</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biology and Life Sciences ; Blood pressure ; Brain ; Brain injury ; Casualties ; Disease Models, Animal ; Fatalities ; Head injuries ; Hemoglobin ; Hemorrhage ; Hemorrhage - etiology ; Hemorrhage - mortality ; Hemorrhage - physiopathology ; Hepatic Veins - injuries ; Humans ; Injuries ; Laboratory animals ; Liver ; Livestock ; Male ; Medicine and Health Sciences ; Mercury ; Mortality ; Portal vein ; Portal Vein - injuries ; Research and Analysis Methods ; Studies ; Surgery ; Sus scrofa ; Swine ; Trauma ; Vascular surgery</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e108293-e108293</ispartof><rights>2014. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-e63145d868f6f3feba8412f8b535326ee709447d7fdb6734994c7ee76a5cc2663</citedby><cites>FETCH-LOGICAL-c526t-e63145d868f6f3feba8412f8b535326ee709447d7fdb6734994c7ee76a5cc2663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176969/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176969/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25251401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Raju, Raghavan</contributor><creatorcontrib>Yanala, Ujwal R</creatorcontrib><creatorcontrib>Johanning, Jason M</creatorcontrib><creatorcontrib>Pipinos, Iraklis I</creatorcontrib><creatorcontrib>Larsen, Gustavo</creatorcontrib><creatorcontrib>Velander, William H</creatorcontrib><creatorcontrib>Carlson, Mark A</creatorcontrib><title>Development of a fatal noncompressible truncal hemorrhage model with combined hepatic and portal venous injury in normothermic normovolemic swine</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ∼ 50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34-36 kg) underwent one of three injury types through a midline incision: 1) central stellate injury (N = 6); 2) excision of a portal vein branch distal to the main PV trunk (N = 6); or 3) hemi-transection of the left lateral lobe of the liver at its base (N = 10). The one-hour mortality of these injuries was 0, 82, and 40%, respectively; the final mean arterial pressure was 65, 24, and 30 mm Hg, respectively; and the final hemoglobin was 8.3, 2.3, and 3.6 g/dL, respectively. Hemi-transection of the left lateral lobe of the liver appeared to target our desired mortality rate better than the other injury mechanisms.</description><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Brain</subject><subject>Brain injury</subject><subject>Casualties</subject><subject>Disease Models, Animal</subject><subject>Fatalities</subject><subject>Head injuries</subject><subject>Hemoglobin</subject><subject>Hemorrhage</subject><subject>Hemorrhage - etiology</subject><subject>Hemorrhage - mortality</subject><subject>Hemorrhage - physiopathology</subject><subject>Hepatic Veins - injuries</subject><subject>Humans</subject><subject>Injuries</subject><subject>Laboratory animals</subject><subject>Liver</subject><subject>Livestock</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mercury</subject><subject>Mortality</subject><subject>Portal vein</subject><subject>Portal Vein - injuries</subject><subject>Research and Analysis Methods</subject><subject>Studies</subject><subject>Surgery</subject><subject>Sus scrofa</subject><subject>Swine</subject><subject>Trauma</subject><subject>Vascular surgery</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptks1u1DAQxyMEoqXwBggsceGyi7-TXJBQoaVSJS5wthx7ssnKsYOdbNXH4I1xumnVIk7jmfnPzzOjKYq3BG8JK8mnfZij1247Bg9bTHBFa_asOCU1oxtJMXv-6H1SvEppj7FglZQvixMqqCAck9Piz1c4gAvjAH5CoUUatXrSDvngTRjGCCn1jQM0xdmbHO9gCDF2egdoCBYcuumnDmVp03uwOT3qqTdIe4vGEBfSAXyYE-r9fo632WR0HMLUQRyy8M45BAeLk24y5HXxotUuwZvVnhW_Lr79PP--uf5xeXX-5XpjBJXTBiQjXNhKVq1sWQuNrjihbdUIJhiVACWuOS9t2dpGlozXNTdljkotjKFSsrPi_ZE7upDUus2kiJBcklJUi-LqqLBB79UY-0HHWxV0r-4CIe6UjnlaB4pYAlAxYSiRnDFdW0ooB02rWuIG08z6vP42NwNYk9cdtXsCfZrxfad24aA4KWUt6wz4uAJi-D1DmtTQJwPOaQ95v0vfsqIS40X64R_p_6fjR5WJIaUI7UMzBKvlwu6r1HJhar2wXPbu8SAPRfcnxf4CDULSZQ</recordid><startdate>20140924</startdate><enddate>20140924</enddate><creator>Yanala, Ujwal R</creator><creator>Johanning, Jason M</creator><creator>Pipinos, Iraklis I</creator><creator>Larsen, Gustavo</creator><creator>Velander, William H</creator><creator>Carlson, Mark A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140924</creationdate><title>Development of a fatal noncompressible truncal hemorrhage model with combined hepatic and portal venous injury in normothermic normovolemic swine</title><author>Yanala, Ujwal R ; Johanning, Jason M ; Pipinos, Iraklis I ; Larsen, Gustavo ; Velander, William H ; Carlson, Mark A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-e63145d868f6f3feba8412f8b535326ee709447d7fdb6734994c7ee76a5cc2663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Blood pressure</topic><topic>Brain</topic><topic>Brain injury</topic><topic>Casualties</topic><topic>Disease Models, Animal</topic><topic>Fatalities</topic><topic>Head injuries</topic><topic>Hemoglobin</topic><topic>Hemorrhage</topic><topic>Hemorrhage - etiology</topic><topic>Hemorrhage - mortality</topic><topic>Hemorrhage - physiopathology</topic><topic>Hepatic Veins - injuries</topic><topic>Humans</topic><topic>Injuries</topic><topic>Laboratory animals</topic><topic>Liver</topic><topic>Livestock</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Mercury</topic><topic>Mortality</topic><topic>Portal vein</topic><topic>Portal Vein - injuries</topic><topic>Research and Analysis Methods</topic><topic>Studies</topic><topic>Surgery</topic><topic>Sus scrofa</topic><topic>Swine</topic><topic>Trauma</topic><topic>Vascular surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanala, Ujwal R</creatorcontrib><creatorcontrib>Johanning, Jason M</creatorcontrib><creatorcontrib>Pipinos, Iraklis I</creatorcontrib><creatorcontrib>Larsen, Gustavo</creatorcontrib><creatorcontrib>Velander, William H</creatorcontrib><creatorcontrib>Carlson, Mark A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanala, Ujwal R</au><au>Johanning, Jason M</au><au>Pipinos, Iraklis I</au><au>Larsen, Gustavo</au><au>Velander, William H</au><au>Carlson, Mark A</au><au>Raju, Raghavan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a fatal noncompressible truncal hemorrhage model with combined hepatic and portal venous injury in normothermic normovolemic swine</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-09-24</date><risdate>2014</risdate><volume>9</volume><issue>9</issue><spage>e108293</spage><epage>e108293</epage><pages>e108293-e108293</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ∼ 50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34-36 kg) underwent one of three injury types through a midline incision: 1) central stellate injury (N = 6); 2) excision of a portal vein branch distal to the main PV trunk (N = 6); or 3) hemi-transection of the left lateral lobe of the liver at its base (N = 10). The one-hour mortality of these injuries was 0, 82, and 40%, respectively; the final mean arterial pressure was 65, 24, and 30 mm Hg, respectively; and the final hemoglobin was 8.3, 2.3, and 3.6 g/dL, respectively. Hemi-transection of the left lateral lobe of the liver appeared to target our desired mortality rate better than the other injury mechanisms.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25251401</pmid><doi>10.1371/journal.pone.0108293</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-09, Vol.9 (9), p.e108293-e108293 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1564617586 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Biology and Life Sciences Blood pressure Brain Brain injury Casualties Disease Models, Animal Fatalities Head injuries Hemoglobin Hemorrhage Hemorrhage - etiology Hemorrhage - mortality Hemorrhage - physiopathology Hepatic Veins - injuries Humans Injuries Laboratory animals Liver Livestock Male Medicine and Health Sciences Mercury Mortality Portal vein Portal Vein - injuries Research and Analysis Methods Studies Surgery Sus scrofa Swine Trauma Vascular surgery |
| title | Development of a fatal noncompressible truncal hemorrhage model with combined hepatic and portal venous injury in normothermic normovolemic swine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T15%3A51%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20a%20fatal%20noncompressible%20truncal%20hemorrhage%20model%20with%20combined%20hepatic%20and%20portal%20venous%20injury%20in%20normothermic%20normovolemic%20swine&rft.jtitle=PloS%20one&rft.au=Yanala,%20Ujwal%20R&rft.date=2014-09-24&rft.volume=9&rft.issue=9&rft.spage=e108293&rft.epage=e108293&rft.pages=e108293-e108293&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0108293&rft_dat=%3Cproquest_plos_%3E1566826009%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1564617586&rft_id=info:pmid/25251401&rft_doaj_id=oai_doaj_org_article_1d1ee835c216433a9d2124ea28960b02&rfr_iscdi=true |