Familial correlations of onset age of hepatocellular carcinoma: a population-based case-control family study
There was lack of evidence for familial aggregation in onset age of hepatocellular carcinoma (HCC) in Chinese population. We conducted a population-based case-control family study to examine familial correlation of age of HCC onset in Taixing, China. A total of 202 cases and 202 matched controls as...
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| Veröffentlicht in: | PloS one 2014-09, Vol.9 (9), p.e108391-e108391 |
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| creator | Liu, Li Li, Lixia Zhou, Shudong Jiang, Qingwu Chen, Sidong Gao, Yanhui Chen, Yue |
| description | There was lack of evidence for familial aggregation in onset age of hepatocellular carcinoma (HCC) in Chinese population. We conducted a population-based case-control family study to examine familial correlation of age of HCC onset in Taixing, China.
A total of 202 cases and 202 matched controls as well as their relatives were included in the study. Lifetime cumulative risks of HCC were estimated using the Kaplan-Meier approach. Cross ratios (CRs) were obtained from stratified Cox proportional hazard models, to assess the familial correlation of onset age.
The mean age of HCC onset was decreased as increasing number of HCC cases in a family. The onset age was the earliest for first-degree relatives, intermediate for second-degree relatives, and latest for non-blood relatives (spouse) (log-rank test, P |
| doi_str_mv | 10.1371/journal.pone.0108391 |
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A total of 202 cases and 202 matched controls as well as their relatives were included in the study. Lifetime cumulative risks of HCC were estimated using the Kaplan-Meier approach. Cross ratios (CRs) were obtained from stratified Cox proportional hazard models, to assess the familial correlation of onset age.
The mean age of HCC onset was decreased as increasing number of HCC cases in a family. The onset age was the earliest for first-degree relatives, intermediate for second-degree relatives, and latest for non-blood relatives (spouse) (log-rank test, P<0.01). The onset age was significantly correlated between probands and their relatives. In stratified Cox proportional hazard models, the CRs for the probands versus their fathers, mothers, siblings and uncles/aunts were 6.25 (95% confidence interval (CI): 1.84-21.25), 9.81 (95% CI: 1.24-77.56), 6.22 (95% CI: 1.37-28.36) and 3.24 (95% CI: 1.26-8.33), respectively. After adjustment for hepatitis B virus infection, the CRs remained significant.
This current study suggested a significant correlation of onset age for HCC among blood relatives. Familial HCC cases yielded earlier age of onset and their relatives have higher HCC risk in early age, highlighting intensive surveillance should be start at an earlier age for individuals with family history of HCC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0108391</identifier><identifier>PMID: 25247419</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Age of Onset ; Aged ; Alcohol ; Alcohol use ; Antigens ; Asian Continental Ancestry Group - genetics ; Asian Continental Ancestry Group - statistics & numerical data ; Blood ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - ethnology ; Carcinoma, Hepatocellular - genetics ; Case-Control Studies ; Child ; China - epidemiology ; Confidence intervals ; Correlation ; Correlation analysis ; Data collection ; Disease ; Drinking water ; Epidemiology ; Families & family life ; Family medical history ; Family studies ; Genetic aspects ; Genetics ; Health aspects ; Hepatitis ; Hepatitis B ; Hepatitis B virus ; Hepatocellular carcinoma ; Humans ; Infant ; Infections ; Kaplan-Meier Estimate ; Liver cancer ; Liver Neoplasms - epidemiology ; Liver Neoplasms - ethnology ; Liver Neoplasms - genetics ; Medical diagnosis ; Medicine and Health Sciences ; Middle Aged ; Neoplastic Syndromes, Hereditary - epidemiology ; Neoplastic Syndromes, Hereditary - ethnology ; Neoplastic Syndromes, Hereditary - genetics ; Pharmaceuticals ; Population ; Population studies ; Population-based studies ; Proportional Hazards Models ; Public health ; Risk ; Studies ; Survival analysis ; Viruses ; Young Adult</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e108391-e108391</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Liu et al 2014 Liu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6510b9fef567613088c9ee2252b37164b4e9df5355eec14688937b50b021cbcf3</citedby><cites>FETCH-LOGICAL-c692t-6510b9fef567613088c9ee2252b37164b4e9df5355eec14688937b50b021cbcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172774/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172774/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25247419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Miao, Xiaoping</contributor><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Li, Lixia</creatorcontrib><creatorcontrib>Zhou, Shudong</creatorcontrib><creatorcontrib>Jiang, Qingwu</creatorcontrib><creatorcontrib>Chen, Sidong</creatorcontrib><creatorcontrib>Gao, Yanhui</creatorcontrib><creatorcontrib>Chen, Yue</creatorcontrib><title>Familial correlations of onset age of hepatocellular carcinoma: a population-based case-control family study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>There was lack of evidence for familial aggregation in onset age of hepatocellular carcinoma (HCC) in Chinese population. We conducted a population-based case-control family study to examine familial correlation of age of HCC onset in Taixing, China.
A total of 202 cases and 202 matched controls as well as their relatives were included in the study. Lifetime cumulative risks of HCC were estimated using the Kaplan-Meier approach. Cross ratios (CRs) were obtained from stratified Cox proportional hazard models, to assess the familial correlation of onset age.
The mean age of HCC onset was decreased as increasing number of HCC cases in a family. The onset age was the earliest for first-degree relatives, intermediate for second-degree relatives, and latest for non-blood relatives (spouse) (log-rank test, P<0.01). The onset age was significantly correlated between probands and their relatives. In stratified Cox proportional hazard models, the CRs for the probands versus their fathers, mothers, siblings and uncles/aunts were 6.25 (95% confidence interval (CI): 1.84-21.25), 9.81 (95% CI: 1.24-77.56), 6.22 (95% CI: 1.37-28.36) and 3.24 (95% CI: 1.26-8.33), respectively. After adjustment for hepatitis B virus infection, the CRs remained significant.
This current study suggested a significant correlation of onset age for HCC among blood relatives. Familial HCC cases yielded earlier age of onset and their relatives have higher HCC risk in early age, highlighting intensive surveillance should be start at an earlier age for individuals with family history of HCC.</description><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Alcohol use</subject><subject>Antigens</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Blood</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - ethnology</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>China - epidemiology</subject><subject>Confidence intervals</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Data collection</subject><subject>Disease</subject><subject>Drinking water</subject><subject>Epidemiology</subject><subject>Families & family life</subject><subject>Family medical history</subject><subject>Family studies</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B virus</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - ethnology</subject><subject>Liver Neoplasms - genetics</subject><subject>Medical diagnosis</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Neoplastic Syndromes, Hereditary - epidemiology</subject><subject>Neoplastic Syndromes, Hereditary - ethnology</subject><subject>Neoplastic Syndromes, Hereditary - genetics</subject><subject>Pharmaceuticals</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Proportional Hazards Models</subject><subject>Public health</subject><subject>Risk</subject><subject>Studies</subject><subject>Survival analysis</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLguhFx6ZJ09QLYVlcHVhY8Os2nKanM1nSppu04vx705nuMpW9kFwkTZ73Tc45PVH0kqQrQgvy4caOrgOz6m2Hq5SkgpbkUXRKSpolPEvp46P1SfTM-5s0zang_Gl0kuUZKxgpTyNzCa02GkysrHNoYNC287Ft4jDhEMMGp48t9jBYhcaMBlyswCnd2RY-xhD3th8PuqQCj3U49Zgo2w3OmriZ_HexH8Z69zx60oDx-GKez6Kfl59_XHxNrq6_rC_OrxLFy2xIeE7SqmywyXnBCU2FUCViFh5dhcA5qxiWdZPTPEdUhHEhSlpUeVqlGVGVauhZ9Prg2xvr5ZwoL0nOGRUFFVkg1geitnAje6dbcDtpQcv9hnUbCW7QyqDkOVONIqVCQpigKRTIIUPGBIAAVMHr03zbWLVYKwyBg1mYLk86vZUb-1syUmRFwYLBu9nA2dsR_SBb7adcQ4d23L-bi4wXBQ3om3_Qh6ObqQ2EAHTX2HCvmkzlOSOCZIEigVo9QIVRY6tD-bDRYX8heL8QTCXGP8MGRu_l-vu3_2evfy3Zt0fsFsEMW2_NuP8VlyA7gMpZ7x0290kmqZya4i4bcmoKOTdFkL06LtC96K4L6F_mKAe5</recordid><startdate>20140923</startdate><enddate>20140923</enddate><creator>Liu, Li</creator><creator>Li, Lixia</creator><creator>Zhou, Shudong</creator><creator>Jiang, Qingwu</creator><creator>Chen, Sidong</creator><creator>Gao, Yanhui</creator><creator>Chen, Yue</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140923</creationdate><title>Familial correlations of onset age of hepatocellular carcinoma: a population-based case-control family study</title><author>Liu, Li ; Li, Lixia ; Zhou, Shudong ; Jiang, Qingwu ; Chen, Sidong ; Gao, Yanhui ; Chen, Yue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6510b9fef567613088c9ee2252b37164b4e9df5355eec14688937b50b021cbcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Alcohol</topic><topic>Alcohol use</topic><topic>Antigens</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Asian Continental Ancestry Group - statistics & numerical data</topic><topic>Blood</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - ethnology</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>China - epidemiology</topic><topic>Confidence intervals</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Data collection</topic><topic>Disease</topic><topic>Drinking water</topic><topic>Epidemiology</topic><topic>Families & family life</topic><topic>Family medical history</topic><topic>Family studies</topic><topic>Genetic aspects</topic><topic>Genetics</topic><topic>Health aspects</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B virus</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Infant</topic><topic>Infections</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Li</au><au>Li, Lixia</au><au>Zhou, Shudong</au><au>Jiang, Qingwu</au><au>Chen, Sidong</au><au>Gao, Yanhui</au><au>Chen, Yue</au><au>Miao, Xiaoping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Familial correlations of onset age of hepatocellular carcinoma: a population-based case-control family study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-09-23</date><risdate>2014</risdate><volume>9</volume><issue>9</issue><spage>e108391</spage><epage>e108391</epage><pages>e108391-e108391</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>There was lack of evidence for familial aggregation in onset age of hepatocellular carcinoma (HCC) in Chinese population. We conducted a population-based case-control family study to examine familial correlation of age of HCC onset in Taixing, China.
A total of 202 cases and 202 matched controls as well as their relatives were included in the study. Lifetime cumulative risks of HCC were estimated using the Kaplan-Meier approach. Cross ratios (CRs) were obtained from stratified Cox proportional hazard models, to assess the familial correlation of onset age.
The mean age of HCC onset was decreased as increasing number of HCC cases in a family. The onset age was the earliest for first-degree relatives, intermediate for second-degree relatives, and latest for non-blood relatives (spouse) (log-rank test, P<0.01). The onset age was significantly correlated between probands and their relatives. In stratified Cox proportional hazard models, the CRs for the probands versus their fathers, mothers, siblings and uncles/aunts were 6.25 (95% confidence interval (CI): 1.84-21.25), 9.81 (95% CI: 1.24-77.56), 6.22 (95% CI: 1.37-28.36) and 3.24 (95% CI: 1.26-8.33), respectively. After adjustment for hepatitis B virus infection, the CRs remained significant.
This current study suggested a significant correlation of onset age for HCC among blood relatives. Familial HCC cases yielded earlier age of onset and their relatives have higher HCC risk in early age, highlighting intensive surveillance should be start at an earlier age for individuals with family history of HCC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25247419</pmid><doi>10.1371/journal.pone.0108391</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-09, Vol.9 (9), p.e108391-e108391 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1564387382 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Age of Onset Aged Alcohol Alcohol use Antigens Asian Continental Ancestry Group - genetics Asian Continental Ancestry Group - statistics & numerical data Blood Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - ethnology Carcinoma, Hepatocellular - genetics Case-Control Studies Child China - epidemiology Confidence intervals Correlation Correlation analysis Data collection Disease Drinking water Epidemiology Families & family life Family medical history Family studies Genetic aspects Genetics Health aspects Hepatitis Hepatitis B Hepatitis B virus Hepatocellular carcinoma Humans Infant Infections Kaplan-Meier Estimate Liver cancer Liver Neoplasms - epidemiology Liver Neoplasms - ethnology Liver Neoplasms - genetics Medical diagnosis Medicine and Health Sciences Middle Aged Neoplastic Syndromes, Hereditary - epidemiology Neoplastic Syndromes, Hereditary - ethnology Neoplastic Syndromes, Hereditary - genetics Pharmaceuticals Population Population studies Population-based studies Proportional Hazards Models Public health Risk Studies Survival analysis Viruses Young Adult |
| title | Familial correlations of onset age of hepatocellular carcinoma: a population-based case-control family study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T06%3A21%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Familial%20correlations%20of%20onset%20age%20of%20hepatocellular%20carcinoma:%20a%20population-based%20case-control%20family%20study&rft.jtitle=PloS%20one&rft.au=Liu,%20Li&rft.date=2014-09-23&rft.volume=9&rft.issue=9&rft.spage=e108391&rft.epage=e108391&rft.pages=e108391-e108391&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0108391&rft_dat=%3Cgale_plos_%3EA418127381%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1564387382&rft_id=info:pmid/25247419&rft_galeid=A418127381&rft_doaj_id=oai_doaj_org_article_654cfc19ce114830a7e6a2e448aa8aec&rfr_iscdi=true |