Pronounced effects of HERG-blockers E-4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbits

Prolongation of action potential duration (APD), increased spatial APD dispersion, and triangulation are major factors promoting drug-induced ventricular arrhythmia. Preclinical identification of HERG/IKr-blocking drugs and their pro-arrhythmic potential, however, remains a challenge. We hypothesize...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e107210-e107210
Hauptverfasser:	Ziupa, David, Beck, Julia, Franke, Gerlind, Perez Feliz, Stefanie, Hartmann, Maximilian, Koren, Gideon, Zehender, Manfred, Bode, Christoph, Brunner, Michael, Odening, Katja E
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - drug effects Action Potentials - physiology Analysis Animals Animals, Genetically Modified Antibiotics Arrhythmia Biology and Life Sciences Cardiac arrhythmia Dispersion Drugs Electrocardiography Erythromycin Erythromycin - pharmacology Erythromycin - therapeutic use Female Genetic engineering Heart - drug effects Heart - physiopathology Long QT Syndrome - drug therapy Long QT Syndrome - physiopathology Medicine and Health Sciences Mutation Piperidines - pharmacology Piperidines - therapeutic use Potassium Prolongation Pyridines - pharmacology Pyridines - therapeutic use Rabbits Research and Analysis Methods Transgenic Triangulation Ventricle
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