BdcA, a protein important for Escherichia coli biofilm dispersal, is a short-chain dehydrogenase/reductase that binds specifically to NADPH

The Escherichia coli protein BdcA (previously referred to as YjgI) plays a key role in the dispersal of cells from bacterial biofilms, and its constitutive activation provides an attractive therapeutic target for dismantling these communities. In order to investigate the function of BdcA at a molecu...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e105751
Hauptverfasser:	Lord, Dana M, Baran, Ayse Uzgoren, Wood, Thomas K, Peti, Wolfgang, Page, Rebecca
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus megaterium Bacteria bacterial biofilms BASIC BIOLOGICAL SCIENCES biochemical cofactors Biochemistry Biofilms Biofilms - growth & development Biology and Life Sciences Chains Chemistry Crystal structure Data collection Dehydrogenase Dehydrogenases dimers Dismantling Dispersal Dispersion E coli Escherichia coli Escherichia coli - metabolism Escherichia coli Proteins - metabolism health care isothermal titration calorimetry Ligands Molecular biology monomers NAD NADP NADP - metabolism oxidoreductases Pharmacology Physiology Protein Binding Protein Conformation protein structure Proteins Reductase Staphylococcus infections Structure-function relationships Substrate Specificity Thermal denaturation
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