The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons
The human immune system undergoes age-related changes that can lead to increased disease susceptibility. Using the baboon as a model for human immune system aging, we examined age-related changes in relative and absolute numbers of T cell subpopulations, cytomegalovirus (CMV) titer and markers of in...
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| creator | Willis, Erin L Eberle, Richard Wolf, Roman F White, Gary L McFarlane, Dianne |
| description | The human immune system undergoes age-related changes that can lead to increased disease susceptibility. Using the baboon as a model for human immune system aging, we examined age-related changes in relative and absolute numbers of T cell subpopulations, cytomegalovirus (CMV) titer and markers of inflammation. In addition, the effect of gender, social status and peer group on lymphocyte subpopulations was determined. Relative and absolute numbers of total lymphocytes (CD3+), T helper cells (CD4+), and cytotoxic T cells (CD8+) increased with age. The proportion of naïve T cells (CD45RA+) decreased, while the total number of cells negative for the co-stimulatory receptor, CD28 (CD28-) increased in an age-dependent manner. Furthermore, CMV titers were negatively correlated with the number of naive CD4+ cells. IL-6 and cortisol concentration were also negatively associated with T cell subpopulations. Additionally, socially dominant baboons exhibited decreases in naïve CD4+ and CD8+ cells (by 65% and 52%, respectively) compared to subordinate animals. These results suggest that factors such as CMV exposure and inflammation may contribute to the age-related decline in immune health and indicate that factors like social status should be considered when studying immunosenescence in animal models. |
| doi_str_mv | 10.1371/journal.pone.0107167 |
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Using the baboon as a model for human immune system aging, we examined age-related changes in relative and absolute numbers of T cell subpopulations, cytomegalovirus (CMV) titer and markers of inflammation. In addition, the effect of gender, social status and peer group on lymphocyte subpopulations was determined. Relative and absolute numbers of total lymphocytes (CD3+), T helper cells (CD4+), and cytotoxic T cells (CD8+) increased with age. The proportion of naïve T cells (CD45RA+) decreased, while the total number of cells negative for the co-stimulatory receptor, CD28 (CD28-) increased in an age-dependent manner. Furthermore, CMV titers were negatively correlated with the number of naive CD4+ cells. IL-6 and cortisol concentration were also negatively associated with T cell subpopulations. Additionally, socially dominant baboons exhibited decreases in naïve CD4+ and CD8+ cells (by 65% and 52%, respectively) compared to subordinate animals. These results suggest that factors such as CMV exposure and inflammation may contribute to the age-related decline in immune health and indicate that factors like social status should be considered when studying immunosenescence in animal models.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0107167</identifier><identifier>PMID: 25244034</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Age Factors ; Aging ; Aging - blood ; Aging - immunology ; Aging - pathology ; Analysis ; Animal models ; Animals ; Antigens ; Atherosclerosis ; B cells ; Baboons ; Biology and Life Sciences ; Biomarkers - blood ; CD28 antigen ; CD3 antigen ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - pathology ; CD45RA antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - pathology ; Cortisol ; Cytokines ; Cytomegalovirus ; Cytomegalovirus Infections - blood ; Cytomegalovirus Infections - immunology ; Cytomegalovirus Infections - pathology ; Cytotoxicity ; Glucocorticoids ; Health sciences ; Helper cells ; Hydrocortisone - blood ; Immune system ; Immune System - immunology ; Immune System - pathology ; Immunosenescence ; Infections ; Inflammation ; Inflammation - blood ; Inflammation - immunology ; Inflammation - pathology ; Interleukin 6 ; Interleukin-6 - blood ; Lymphocytes ; Lymphocytes T ; Markers ; Older people ; Papio ; Physiology ; Research and Analysis Methods ; Social aspects ; Social interactions ; Subpopulations ; T cells ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - pathology ; Viral infections</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e107167-e107167</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Willis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Willis et al 2014 Willis et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8dd59d5ad2aa10b01a616ac0e373d7294c0887a2e55a6b18f8e55ea227092e363</citedby><cites>FETCH-LOGICAL-c692t-8dd59d5ad2aa10b01a616ac0e373d7294c0887a2e55a6b18f8e55ea227092e363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170980/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170980/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25244034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dowd, Jennifer Beam</contributor><creatorcontrib>Willis, Erin L</creatorcontrib><creatorcontrib>Eberle, Richard</creatorcontrib><creatorcontrib>Wolf, Roman F</creatorcontrib><creatorcontrib>White, Gary L</creatorcontrib><creatorcontrib>McFarlane, Dianne</creatorcontrib><title>The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The human immune system undergoes age-related changes that can lead to increased disease susceptibility. Using the baboon as a model for human immune system aging, we examined age-related changes in relative and absolute numbers of T cell subpopulations, cytomegalovirus (CMV) titer and markers of inflammation. In addition, the effect of gender, social status and peer group on lymphocyte subpopulations was determined. Relative and absolute numbers of total lymphocytes (CD3+), T helper cells (CD4+), and cytotoxic T cells (CD8+) increased with age. The proportion of naïve T cells (CD45RA+) decreased, while the total number of cells negative for the co-stimulatory receptor, CD28 (CD28-) increased in an age-dependent manner. Furthermore, CMV titers were negatively correlated with the number of naive CD4+ cells. IL-6 and cortisol concentration were also negatively associated with T cell subpopulations. Additionally, socially dominant baboons exhibited decreases in naïve CD4+ and CD8+ cells (by 65% and 52%, respectively) compared to subordinate animals. These results suggest that factors such as CMV exposure and inflammation may contribute to the age-related decline in immune health and indicate that factors like social status should be considered when studying immunosenescence in animal models.</description><subject>Age</subject><subject>Age Factors</subject><subject>Aging</subject><subject>Aging - blood</subject><subject>Aging - immunology</subject><subject>Aging - pathology</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antigens</subject><subject>Atherosclerosis</subject><subject>B cells</subject><subject>Baboons</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - blood</subject><subject>CD28 antigen</subject><subject>CD3 antigen</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - pathology</subject><subject>CD45RA antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - pathology</subject><subject>Cortisol</subject><subject>Cytokines</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections - blood</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Cytomegalovirus Infections - pathology</subject><subject>Cytotoxicity</subject><subject>Glucocorticoids</subject><subject>Health sciences</subject><subject>Helper cells</subject><subject>Hydrocortisone - blood</subject><subject>Immune system</subject><subject>Immune System - immunology</subject><subject>Immune System - pathology</subject><subject>Immunosenescence</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - immunology</subject><subject>Inflammation - pathology</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Markers</subject><subject>Older people</subject><subject>Papio</subject><subject>Physiology</subject><subject>Research and Analysis Methods</subject><subject>Social aspects</subject><subject>Social interactions</subject><subject>Subpopulations</subject><subject>T cells</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - pathology</subject><subject>Viral infections</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk02P0zAQhiMEYpeFf4AgEhKCQ4u_4tgXpNWKj0orrQQLV2viTNoUJw5xUtF_j9tmVy3aA8oh1szzvrZnPEnykpI55Tn9sPZj34Kbd77FOaEkpzJ_lJxTzdlMMsIfH63PkmchrAnJuJLyaXLGMiYE4eI88bcrTLGq0A4h9VUKS0yhLVO7HXyDS3B-U_djTLVpA_0v7PdU3VYOmgaGOsZ3uNs23cpHEaad70a3z4TIpRa6od5gWkDhY-h58qQCF_DF9L9Ifnz-dHv1dXZ982VxdXk9s1KzYabKMtNlBiUDoKQgFCSVYAnynJc508ISpXJgmGUgC6oqFVcIjOVEM-SSXySvD76d88FMtQqGZlJQoaVUkVgciNLD2nR9He-3NR5qsw_4fmmgH2rr0FQKVG4zqyTlogSh80pnVaGF0MAKnkWvj9NuY9FgabEdenAnpqeZtl6Zpd8YQeOBFYkG7yaD3v8eMQymqYNF56BFP-7PLRXLSK4j-uYf9OHbTVRsIZrYLx_3tTtTcymookxyvavS_AEqfiU2tY0Pq6pj_ETw_kQQmQH_DEsYQzCL79_-n735ecq-PWJXCG5YBe_G_TM6BcUBtL0PocfqvsiUmN1c3FXD7ObCTHMRZa-OG3QvuhsE_he5pQjZ</recordid><startdate>20140922</startdate><enddate>20140922</enddate><creator>Willis, Erin L</creator><creator>Eberle, Richard</creator><creator>Wolf, Roman F</creator><creator>White, Gary L</creator><creator>McFarlane, Dianne</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140922</creationdate><title>The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons</title><author>Willis, Erin L ; Eberle, Richard ; Wolf, Roman F ; White, Gary L ; McFarlane, Dianne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8dd59d5ad2aa10b01a616ac0e373d7294c0887a2e55a6b18f8e55ea227092e363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Aging</topic><topic>Aging - blood</topic><topic>Aging - immunology</topic><topic>Aging - pathology</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antigens</topic><topic>Atherosclerosis</topic><topic>B cells</topic><topic>Baboons</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - blood</topic><topic>CD28 antigen</topic><topic>CD3 antigen</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - pathology</topic><topic>CD45RA antigen</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - pathology</topic><topic>Cortisol</topic><topic>Cytokines</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus Infections - blood</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Cytomegalovirus Infections - pathology</topic><topic>Cytotoxicity</topic><topic>Glucocorticoids</topic><topic>Health sciences</topic><topic>Helper cells</topic><topic>Hydrocortisone - blood</topic><topic>Immune system</topic><topic>Immune System - immunology</topic><topic>Immune System - pathology</topic><topic>Immunosenescence</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - immunology</topic><topic>Inflammation - pathology</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - blood</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Markers</topic><topic>Older people</topic><topic>Papio</topic><topic>Physiology</topic><topic>Research and Analysis Methods</topic><topic>Social aspects</topic><topic>Social interactions</topic><topic>Subpopulations</topic><topic>T cells</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - pathology</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Willis, Erin L</creatorcontrib><creatorcontrib>Eberle, Richard</creatorcontrib><creatorcontrib>Wolf, Roman F</creatorcontrib><creatorcontrib>White, Gary L</creatorcontrib><creatorcontrib>McFarlane, Dianne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Willis, Erin L</au><au>Eberle, Richard</au><au>Wolf, Roman F</au><au>White, Gary L</au><au>McFarlane, Dianne</au><au>Dowd, Jennifer Beam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-09-22</date><risdate>2014</risdate><volume>9</volume><issue>9</issue><spage>e107167</spage><epage>e107167</epage><pages>e107167-e107167</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The human immune system undergoes age-related changes that can lead to increased disease susceptibility. Using the baboon as a model for human immune system aging, we examined age-related changes in relative and absolute numbers of T cell subpopulations, cytomegalovirus (CMV) titer and markers of inflammation. In addition, the effect of gender, social status and peer group on lymphocyte subpopulations was determined. Relative and absolute numbers of total lymphocytes (CD3+), T helper cells (CD4+), and cytotoxic T cells (CD8+) increased with age. The proportion of naïve T cells (CD45RA+) decreased, while the total number of cells negative for the co-stimulatory receptor, CD28 (CD28-) increased in an age-dependent manner. Furthermore, CMV titers were negatively correlated with the number of naive CD4+ cells. IL-6 and cortisol concentration were also negatively associated with T cell subpopulations. Additionally, socially dominant baboons exhibited decreases in naïve CD4+ and CD8+ cells (by 65% and 52%, respectively) compared to subordinate animals. These results suggest that factors such as CMV exposure and inflammation may contribute to the age-related decline in immune health and indicate that factors like social status should be considered when studying immunosenescence in animal models.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25244034</pmid><doi>10.1371/journal.pone.0107167</doi><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Age Factors Aging Aging - blood Aging - immunology Aging - pathology Analysis Animal models Animals Antigens Atherosclerosis B cells Baboons Biology and Life Sciences Biomarkers - blood CD28 antigen CD3 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD45RA antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cortisol Cytokines Cytomegalovirus Cytomegalovirus Infections - blood Cytomegalovirus Infections - immunology Cytomegalovirus Infections - pathology Cytotoxicity Glucocorticoids Health sciences Helper cells Hydrocortisone - blood Immune system Immune System - immunology Immune System - pathology Immunosenescence Infections Inflammation Inflammation - blood Inflammation - immunology Inflammation - pathology Interleukin 6 Interleukin-6 - blood Lymphocytes Lymphocytes T Markers Older people Papio Physiology Research and Analysis Methods Social aspects Social interactions Subpopulations T cells T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology Viral infections |
| title | The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T14%3A16%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effects%20of%20age%20and%20cytomegalovirus%20on%20markers%20of%20inflammation%20and%20lymphocyte%20populations%20in%20captive%20baboons&rft.jtitle=PloS%20one&rft.au=Willis,%20Erin%20L&rft.date=2014-09-22&rft.volume=9&rft.issue=9&rft.spage=e107167&rft.epage=e107167&rft.pages=e107167-e107167&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0107167&rft_dat=%3Cgale_plos_%3EA418126396%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1564149668&rft_id=info:pmid/25244034&rft_galeid=A418126396&rft_doaj_id=oai_doaj_org_article_f8a87c5c86134da497f95fb9449a2b35&rfr_iscdi=true |