The role of catechol-O-methyl transferase Val(108/158)Met polymorphism (rs4680) in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study
Green tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins. However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the func...
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| description | Green tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins. However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the functional COMT Val108/158Met polymorphism that are associated with COMT enzyme activity; high-activity enzyme, COMT(H)(Val/Val genotype), and low-activity COMT(L)(Met/Met genotype).
Fourteen Caucasian subjects (BMI: 22.2±2.3 kg/m2, age: 21.4±2.2 years) of whom 7 with the COMT(H)-genotype and 7 with the COMT(L)-genotype were included in a randomized, cross-over study in which EE and substrate oxidation were measured with a ventilated-hood system after decaffeinated GT and placebo(PL) consumption.
At baseline, EE, RQ, FATox and carbohydrate oxidation(CHOox) did not differ between groups. Significant interactions were observed between COMT genotypes and treatment for RQ, FATox and CHOox (p |
| doi_str_mv | 10.1371/journal.pone.0106220 |
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Fourteen Caucasian subjects (BMI: 22.2±2.3 kg/m2, age: 21.4±2.2 years) of whom 7 with the COMT(H)-genotype and 7 with the COMT(L)-genotype were included in a randomized, cross-over study in which EE and substrate oxidation were measured with a ventilated-hood system after decaffeinated GT and placebo(PL) consumption.
At baseline, EE, RQ, FATox and carbohydrate oxidation(CHOox) did not differ between groups. Significant interactions were observed between COMT genotypes and treatment for RQ, FATox and CHOox (p<0.05). After GT vs. PL, EE(GT: 62.2 vs. PL: 35.4 kJ.3.5 hrs; p<0.01), RQ(GT: 0.80 vs. PL: 0.83; p<0.01), FATox(GT: 18.3 vs. PL: 15.3 g/d; p<0.001) and CHOox(GT: 18.5 vs. PL: 24.3 g/d; p<0.001) were significantly different for subjects carrying the COMT(H) genotype, but not for subjects carrying the COMT(L) genotype (EE, GT: 60.3 vs. PL: 51.7 kJ.3.5 hrs; NS), (RQ, GT: 0.81 vs. PL: 0.81; NS), (FATox, GT: 17.3 vs. PL: 17.0 g/d; NS), (CHOox, GT: 22.1 vs. PL: 21.4 g/d; NS).
Subjects carrying the COMT(H) genotype increased energy expenditure and fat-oxidation upon ingestion of green tea catechins vs, placebo, whereas COMT(L) genotype carriers reacted similarly to GT and PL ingestion. The differences in responses were due to the different responses on PL ingestion, but similar responses to GT ingestion, pointing to different mechanisms. The different alleles of the functional COMT Val108/158Met polymorphism appear to play a role in the inter-individual variability for EE and FATox after GT treatment.
Nederlands Trial register NTR1918.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0106220</identifier><identifier>PMID: 25238062</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alcohol ; Alleles ; Biology ; Biology and Life Sciences ; Body mass ; Caffeine ; Camellia sinensis - chemistry ; Carbohydrates ; Catechin ; Catechin - pharmacology ; Catechol ; Catechol O-Methyltransferase - chemistry ; Catechol O-Methyltransferase - genetics ; Clean energy ; Cross-Over Studies ; Energy ; Energy expenditure ; Energy Metabolism - genetics ; Enzymatic activity ; Enzyme activity ; Enzymes ; European Continental Ancestry Group - genetics ; Female ; Flavonoids ; Gene polymorphism ; Genotype ; Genotype & phenotype ; Genotypes ; Green tea ; Humans ; Ingestion ; Lipid Metabolism - genetics ; Male ; Medicine and Health Sciences ; Metabolism ; Metabolites ; Nutrition ; Oxidation ; Oxidation-Reduction ; Pilot Projects ; Polymorphism ; Polymorphism, Genetic ; Polyphenols ; Questionnaires ; Research and Analysis Methods ; Substrates ; Tea ; Thermogenesis ; Toxicology ; Variability ; Ventilation ; White people</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e106220</ispartof><rights>2014 Hursel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Hursel et al 2014 Hursel et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-fb5b11aa6b754382cf2a7034c35faac029243587b27f7de0adbbc8c8739c16723</citedby><cites>FETCH-LOGICAL-c456t-fb5b11aa6b754382cf2a7034c35faac029243587b27f7de0adbbc8c8739c16723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169515/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169515/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25238062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hursel, Rick</creatorcontrib><creatorcontrib>Janssens, Pilou L H R</creatorcontrib><creatorcontrib>Bouwman, Freek G</creatorcontrib><creatorcontrib>Mariman, Edwin C</creatorcontrib><creatorcontrib>Westerterp-Plantenga, Margriet S</creatorcontrib><title>The role of catechol-O-methyl transferase Val(108/158)Met polymorphism (rs4680) in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Green tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins. However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the functional COMT Val108/158Met polymorphism that are associated with COMT enzyme activity; high-activity enzyme, COMT(H)(Val/Val genotype), and low-activity COMT(L)(Met/Met genotype).
Fourteen Caucasian subjects (BMI: 22.2±2.3 kg/m2, age: 21.4±2.2 years) of whom 7 with the COMT(H)-genotype and 7 with the COMT(L)-genotype were included in a randomized, cross-over study in which EE and substrate oxidation were measured with a ventilated-hood system after decaffeinated GT and placebo(PL) consumption.
At baseline, EE, RQ, FATox and carbohydrate oxidation(CHOox) did not differ between groups. Significant interactions were observed between COMT genotypes and treatment for RQ, FATox and CHOox (p<0.05). After GT vs. PL, EE(GT: 62.2 vs. PL: 35.4 kJ.3.5 hrs; p<0.01), RQ(GT: 0.80 vs. PL: 0.83; p<0.01), FATox(GT: 18.3 vs. PL: 15.3 g/d; p<0.001) and CHOox(GT: 18.5 vs. PL: 24.3 g/d; p<0.001) were significantly different for subjects carrying the COMT(H) genotype, but not for subjects carrying the COMT(L) genotype (EE, GT: 60.3 vs. PL: 51.7 kJ.3.5 hrs; NS), (RQ, GT: 0.81 vs. PL: 0.81; NS), (FATox, GT: 17.3 vs. PL: 17.0 g/d; NS), (CHOox, GT: 22.1 vs. PL: 21.4 g/d; NS).
Subjects carrying the COMT(H) genotype increased energy expenditure and fat-oxidation upon ingestion of green tea catechins vs, placebo, whereas COMT(L) genotype carriers reacted similarly to GT and PL ingestion. The differences in responses were due to the different responses on PL ingestion, but similar responses to GT ingestion, pointing to different mechanisms. The different alleles of the functional COMT Val108/158Met polymorphism appear to play a role in the inter-individual variability for EE and FATox after GT treatment.
Nederlands Trial register NTR1918.</description><subject>Adult</subject><subject>Alcohol</subject><subject>Alleles</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Caffeine</subject><subject>Camellia sinensis - chemistry</subject><subject>Carbohydrates</subject><subject>Catechin</subject><subject>Catechin - pharmacology</subject><subject>Catechol</subject><subject>Catechol O-Methyltransferase - chemistry</subject><subject>Catechol O-Methyltransferase - genetics</subject><subject>Clean energy</subject><subject>Cross-Over Studies</subject><subject>Energy</subject><subject>Energy expenditure</subject><subject>Energy Metabolism - genetics</subject><subject>Enzymatic activity</subject><subject>Enzyme activity</subject><subject>Enzymes</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Flavonoids</subject><subject>Gene polymorphism</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Green tea</subject><subject>Humans</subject><subject>Ingestion</subject><subject>Lipid Metabolism - 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chemistry</topic><topic>Carbohydrates</topic><topic>Catechin</topic><topic>Catechin - pharmacology</topic><topic>Catechol</topic><topic>Catechol O-Methyltransferase - chemistry</topic><topic>Catechol O-Methyltransferase - genetics</topic><topic>Clean energy</topic><topic>Cross-Over Studies</topic><topic>Energy</topic><topic>Energy expenditure</topic><topic>Energy Metabolism - genetics</topic><topic>Enzymatic activity</topic><topic>Enzyme activity</topic><topic>Enzymes</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Flavonoids</topic><topic>Gene polymorphism</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Green tea</topic><topic>Humans</topic><topic>Ingestion</topic><topic>Lipid Metabolism - genetics</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Nutrition</topic><topic>Oxidation</topic><topic>Oxidation-Reduction</topic><topic>Pilot Projects</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polyphenols</topic><topic>Questionnaires</topic><topic>Research and Analysis Methods</topic><topic>Substrates</topic><topic>Tea</topic><topic>Thermogenesis</topic><topic>Toxicology</topic><topic>Variability</topic><topic>Ventilation</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hursel, Rick</creatorcontrib><creatorcontrib>Janssens, Pilou L H R</creatorcontrib><creatorcontrib>Bouwman, Freek G</creatorcontrib><creatorcontrib>Mariman, Edwin C</creatorcontrib><creatorcontrib>Westerterp-Plantenga, Margriet S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the functional COMT Val108/158Met polymorphism that are associated with COMT enzyme activity; high-activity enzyme, COMT(H)(Val/Val genotype), and low-activity COMT(L)(Met/Met genotype).
Fourteen Caucasian subjects (BMI: 22.2±2.3 kg/m2, age: 21.4±2.2 years) of whom 7 with the COMT(H)-genotype and 7 with the COMT(L)-genotype were included in a randomized, cross-over study in which EE and substrate oxidation were measured with a ventilated-hood system after decaffeinated GT and placebo(PL) consumption.
At baseline, EE, RQ, FATox and carbohydrate oxidation(CHOox) did not differ between groups. Significant interactions were observed between COMT genotypes and treatment for RQ, FATox and CHOox (p<0.05). After GT vs. PL, EE(GT: 62.2 vs. PL: 35.4 kJ.3.5 hrs; p<0.01), RQ(GT: 0.80 vs. PL: 0.83; p<0.01), FATox(GT: 18.3 vs. PL: 15.3 g/d; p<0.001) and CHOox(GT: 18.5 vs. PL: 24.3 g/d; p<0.001) were significantly different for subjects carrying the COMT(H) genotype, but not for subjects carrying the COMT(L) genotype (EE, GT: 60.3 vs. PL: 51.7 kJ.3.5 hrs; NS), (RQ, GT: 0.81 vs. PL: 0.81; NS), (FATox, GT: 17.3 vs. PL: 17.0 g/d; NS), (CHOox, GT: 22.1 vs. PL: 21.4 g/d; NS).
Subjects carrying the COMT(H) genotype increased energy expenditure and fat-oxidation upon ingestion of green tea catechins vs, placebo, whereas COMT(L) genotype carriers reacted similarly to GT and PL ingestion. The differences in responses were due to the different responses on PL ingestion, but similar responses to GT ingestion, pointing to different mechanisms. The different alleles of the functional COMT Val108/158Met polymorphism appear to play a role in the inter-individual variability for EE and FATox after GT treatment.
Nederlands Trial register NTR1918.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25238062</pmid><doi>10.1371/journal.pone.0106220</doi><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1563701918 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Alcohol Alleles Biology Biology and Life Sciences Body mass Caffeine Camellia sinensis - chemistry Carbohydrates Catechin Catechin - pharmacology Catechol Catechol O-Methyltransferase - chemistry Catechol O-Methyltransferase - genetics Clean energy Cross-Over Studies Energy Energy expenditure Energy Metabolism - genetics Enzymatic activity Enzyme activity Enzymes European Continental Ancestry Group - genetics Female Flavonoids Gene polymorphism Genotype Genotype & phenotype Genotypes Green tea Humans Ingestion Lipid Metabolism - genetics Male Medicine and Health Sciences Metabolism Metabolites Nutrition Oxidation Oxidation-Reduction Pilot Projects Polymorphism Polymorphism, Genetic Polyphenols Questionnaires Research and Analysis Methods Substrates Tea Thermogenesis Toxicology Variability Ventilation White people |
| title | The role of catechol-O-methyl transferase Val(108/158)Met polymorphism (rs4680) in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T18%3A26%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20catechol-O-methyl%20transferase%20Val(108/158)Met%20polymorphism%20(rs4680)%20in%20the%20effect%20of%20green%20tea%20on%20resting%20energy%20expenditure%20and%20fat%20oxidation:%20a%20pilot%20study&rft.jtitle=PloS%20one&rft.au=Hursel,%20Rick&rft.date=2014-09-19&rft.volume=9&rft.issue=9&rft.spage=e106220&rft.pages=e106220-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0106220&rft_dat=%3Cproquest_plos_%3E3437397621%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1563701918&rft_id=info:pmid/25238062&rft_doaj_id=oai_doaj_org_article_1a6368299df6412abf08df9a918b4604&rfr_iscdi=true |