Ocular localization and transduction by adenoviral vectors are serotype-dependent and can be modified by inclusion of RGD fiber modifications

To evaluate localization and transgene expression from adenoviral vector of serotypes 5, 35, and 28, ± an RGD motif in the fiber following intravitreal or subretinal administration. Ocular transduction by adenoviral vector serotypes ± RGD was studied in the eyes of mice receiving an intravitreous or...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e108071-e108071
Hauptverfasser:	Ueyama, Kazuhiro, Mori, Keisuke, Shoji, Takuhei, Omata, Hidekazu, Gehlbach, Peter L, Brough, Douglas E, Wei, Lisa L, Yoneya, Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Animals Biology and Life Sciences Chemical compounds Clonal deletion Cornea Cytomegalovirus Expression vectors Eye Eye (anatomy) Eye diseases Female Gene deletion Gene Expression Gene therapy Genomes Green Fluorescent Proteins - biosynthesis Green Fluorescent Proteins - genetics Health aspects Injections, Intraocular Iris Laboratory animals Localization LUC gene Luciferase Macular degeneration Medicine and Health Sciences Mice, Inbred C57BL Oligopeptides - genetics Pathogenesis Pharmacology Proteins Research and Analysis Methods Serotypes Transduction, Genetic Vectors (Biology)
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