Impact of vitamin D supplementation during lactation on vitamin D status and body composition of mother-infant pairs: a MAVID randomized controlled trial
The optimal vitamin D intake for nursing women is controversial. Deterioration, at least in bone mass, is reported during lactation. This study evaluated whether vitamin D supplementation during lactation enhances the maternal and infant's vitamin D status, bone mass and body composition. After...
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| Veröffentlicht in: | PloS one 2014-09, Vol.9 (9), p.e107708-e107708 |
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| creator | Czech-Kowalska, Justyna Latka-Grot, Julita Bulsiewicz, Dorota Jaworski, Maciej Pludowski, Pawel Wygledowska, Grazyna Chazan, Bogdan Pawlus, Beata Zochowska, Anna Borszewska-Kornacka, Maria K Karczmarewicz, Elzbieta Czekuc-Kryskiewicz, Edyta Dobrzanska, Anna |
| description | The optimal vitamin D intake for nursing women is controversial. Deterioration, at least in bone mass, is reported during lactation. This study evaluated whether vitamin D supplementation during lactation enhances the maternal and infant's vitamin D status, bone mass and body composition.
After term delivery, 174 healthy mothers were randomized to receive 1200 IU/d (800 IU/d+400 IU/d from multivitamins) or 400 IU/d (placebo+400 IU/d from multivitamins) of cholecalciferol for 6 months while breastfeeding. All infants received 400 IU/d of cholecalciferol. Serum 25-hydroxyvitamin D [25(OH)D], iPTH, calcium, urinary calcium, and densitometry were performed in mother-offspring pairs after delivery, and at 3 and 6 months later.
A total of 137 (79%) (n = 70; 1200 IU/d, n = 67; 400 IU/d) completed the study. 25(OH)D was similar in both groups at baseline (13.7 ng/ml vs. 16.1 ng/ml; P = 0.09) and at 3 months (25.7 ng/ml vs. 24.5 ng/ml; P = 0.09), but appeared higher in the 1200 IU/d group at 6 months of supplementation (25.6 ng/ml vs. 23.1 ng/ml; P = 0.009). The prevalence of 25(OH)D 20 ng/ml in nursing women, while 1200 IU/d appeared more effective, but had no effect on breastfed offspring vitamin D status, or changes in the bone mass and the body composition observed in both during breastfeeding.
ClinicalTrials.gov NCT01506557. |
| doi_str_mv | 10.1371/journal.pone.0107708 |
| format | Article |
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After term delivery, 174 healthy mothers were randomized to receive 1200 IU/d (800 IU/d+400 IU/d from multivitamins) or 400 IU/d (placebo+400 IU/d from multivitamins) of cholecalciferol for 6 months while breastfeeding. All infants received 400 IU/d of cholecalciferol. Serum 25-hydroxyvitamin D [25(OH)D], iPTH, calcium, urinary calcium, and densitometry were performed in mother-offspring pairs after delivery, and at 3 and 6 months later.
A total of 137 (79%) (n = 70; 1200 IU/d, n = 67; 400 IU/d) completed the study. 25(OH)D was similar in both groups at baseline (13.7 ng/ml vs. 16.1 ng/ml; P = 0.09) and at 3 months (25.7 ng/ml vs. 24.5 ng/ml; P = 0.09), but appeared higher in the 1200 IU/d group at 6 months of supplementation (25.6 ng/ml vs. 23.1 ng/ml; P = 0.009). The prevalence of 25(OH)D <20 ng/ml was comparable between groups at baseline (71% vs. 64%, P = 0.36) but lower in the 1200 IU/d group after 3 months (9% vs. 25%, P = 0.009) and 6 months (14% vs. 30%, P = 0.03). Maternal and infants' iPTH, calciuria, bone mass and body composition as well as infants' 25(OH)D levels were not significantly different between groups during the study. Significant negative correlations were noted between maternal 25(OH)D and fat mass (R = -0.49, P = 0.00001), android fat mass (R = -0.53, P = 0.00001), and gynoid fat mass (R = -0.43, P = 0.00001) after 6 months of supplementation.
Vitamin D supplementation at a dose of 400 IU/d was not sufficient to maintain 25(OH)D >20 ng/ml in nursing women, while 1200 IU/d appeared more effective, but had no effect on breastfed offspring vitamin D status, or changes in the bone mass and the body composition observed in both during breastfeeding.
ClinicalTrials.gov NCT01506557.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0107708</identifier><identifier>PMID: 25232839</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>25-Hydroxyvitamin D ; Adult ; Babies ; Biochemistry ; Biology and Life Sciences ; Birth Weight ; Body Composition ; Body fat ; Body Mass Index ; Bone composition ; Bone Density ; Bone mass ; Breast Feeding ; Breastfeeding & lactation ; Calcium ; Calcium (urinary) ; Calcium - blood ; Calciuria ; Cholecalciferol - administration & dosage ; Correlation analysis ; Densitometers ; Densitometry ; Diabetes ; Dietary Supplements ; Double-Blind Method ; Drug dosages ; Ethics ; Families & family life ; Female ; Hospitals ; Humans ; Infant, Newborn ; Infants ; Intensive care ; Lactation ; Male ; Medicine ; Medicine and Health Sciences ; Metabolism ; Methyltestosterone ; Mothers ; Newborn babies ; Nursing ; Offspring ; Parathyroid Hormone - blood ; Physiological aspects ; Pregnancy ; Prospective Studies ; Randomization ; Supplements ; Treatment Outcome ; Vitamin D ; Vitamin deficiency ; Vitamins - administration & dosage ; Womens health</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e107708-e107708</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Czech-Kowalska et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Czech-Kowalska et al 2014 Czech-Kowalska et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-7815c41e13a2c8f593f5eeeaf7f1c69e9281d54b5f8917fac25799d4bb07197f3</citedby><cites>FETCH-LOGICAL-c692t-7815c41e13a2c8f593f5eeeaf7f1c69e9281d54b5f8917fac25799d4bb07197f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169453/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169453/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25232839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cameron, D. W.</contributor><creatorcontrib>Czech-Kowalska, Justyna</creatorcontrib><creatorcontrib>Latka-Grot, Julita</creatorcontrib><creatorcontrib>Bulsiewicz, Dorota</creatorcontrib><creatorcontrib>Jaworski, Maciej</creatorcontrib><creatorcontrib>Pludowski, Pawel</creatorcontrib><creatorcontrib>Wygledowska, Grazyna</creatorcontrib><creatorcontrib>Chazan, Bogdan</creatorcontrib><creatorcontrib>Pawlus, Beata</creatorcontrib><creatorcontrib>Zochowska, Anna</creatorcontrib><creatorcontrib>Borszewska-Kornacka, Maria K</creatorcontrib><creatorcontrib>Karczmarewicz, Elzbieta</creatorcontrib><creatorcontrib>Czekuc-Kryskiewicz, Edyta</creatorcontrib><creatorcontrib>Dobrzanska, Anna</creatorcontrib><title>Impact of vitamin D supplementation during lactation on vitamin D status and body composition of mother-infant pairs: a MAVID randomized controlled trial</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The optimal vitamin D intake for nursing women is controversial. Deterioration, at least in bone mass, is reported during lactation. This study evaluated whether vitamin D supplementation during lactation enhances the maternal and infant's vitamin D status, bone mass and body composition.
After term delivery, 174 healthy mothers were randomized to receive 1200 IU/d (800 IU/d+400 IU/d from multivitamins) or 400 IU/d (placebo+400 IU/d from multivitamins) of cholecalciferol for 6 months while breastfeeding. All infants received 400 IU/d of cholecalciferol. Serum 25-hydroxyvitamin D [25(OH)D], iPTH, calcium, urinary calcium, and densitometry were performed in mother-offspring pairs after delivery, and at 3 and 6 months later.
A total of 137 (79%) (n = 70; 1200 IU/d, n = 67; 400 IU/d) completed the study. 25(OH)D was similar in both groups at baseline (13.7 ng/ml vs. 16.1 ng/ml; P = 0.09) and at 3 months (25.7 ng/ml vs. 24.5 ng/ml; P = 0.09), but appeared higher in the 1200 IU/d group at 6 months of supplementation (25.6 ng/ml vs. 23.1 ng/ml; P = 0.009). The prevalence of 25(OH)D <20 ng/ml was comparable between groups at baseline (71% vs. 64%, P = 0.36) but lower in the 1200 IU/d group after 3 months (9% vs. 25%, P = 0.009) and 6 months (14% vs. 30%, P = 0.03). Maternal and infants' iPTH, calciuria, bone mass and body composition as well as infants' 25(OH)D levels were not significantly different between groups during the study. Significant negative correlations were noted between maternal 25(OH)D and fat mass (R = -0.49, P = 0.00001), android fat mass (R = -0.53, P = 0.00001), and gynoid fat mass (R = -0.43, P = 0.00001) after 6 months of supplementation.
Vitamin D supplementation at a dose of 400 IU/d was not sufficient to maintain 25(OH)D >20 ng/ml in nursing women, while 1200 IU/d appeared more effective, but had no effect on breastfed offspring vitamin D status, or changes in the bone mass and the body composition observed in both during breastfeeding.
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blood</subject><subject>Physiological aspects</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Randomization</subject><subject>Supplements</subject><subject>Treatment Outcome</subject><subject>Vitamin D</subject><subject>Vitamin deficiency</subject><subject>Vitamins - administration & dosage</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QDgujFjEnTNIkXwrDrx8DKgh97G9I0mcmQNjVJF9d_4r81Y2eXGdkLaaCH0-d9k5zTUxRPEZwjTNGbjR9DL9188L2eQwQphexecYw4Lmd1CfH9vfioeBTjBkKCWV0_LI5KUuKSYX5c_F52g1QJeAOubJKd7cEZiOMwON3pPslkfQ_aMdh-BVwGp0Ree3ROjhHIvgWNb6-B8t3go51AAzqf1jrMbG9kn8AgbYhvgQSfF5fLMxCyynf2l26zrE_BO5fDFKx0j4sHRrqon-zeJ8X3D--_nX6anV98XJ4uzmeq5mWaUYaIqpBGWJaKGcKxIVpraahBmdC8ZKglVUMM44gaqUpCOW-rpoEUcWrwSfF88h2cj2JX1SgQqTGsGMFVJpYT0Xq5EUOwnQzXwksr_iZ8WAkZklVOC1XDklLSMk54JWHdYAU15KxGGNJKyez1brfb2HS6VbnGQboD08MvvV2Llb8SFap5RXA2eLUzCP7HqGMSnY1KOyd77cfp3JwxiuqMvvgHvft2O2ol8wVym3zeV21NxaJCDOFM8UzN76Dy0-rO5tZpY3P-QPD6QLBtr_6ZVnKMUSy_fvl_9uLykH25x661dGkdvRu3v1s8BKsJVMHHGLS5LTKCYjtBN9UQ2wkSuwnKsmf7DboV3YwM_gMCzxeP</recordid><startdate>20140918</startdate><enddate>20140918</enddate><creator>Czech-Kowalska, Justyna</creator><creator>Latka-Grot, Julita</creator><creator>Bulsiewicz, Dorota</creator><creator>Jaworski, Maciej</creator><creator>Pludowski, Pawel</creator><creator>Wygledowska, Grazyna</creator><creator>Chazan, Bogdan</creator><creator>Pawlus, Beata</creator><creator>Zochowska, Anna</creator><creator>Borszewska-Kornacka, Maria K</creator><creator>Karczmarewicz, Elzbieta</creator><creator>Czekuc-Kryskiewicz, Edyta</creator><creator>Dobrzanska, Anna</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140918</creationdate><title>Impact of vitamin D supplementation during lactation on vitamin D status and body composition of mother-infant pairs: a MAVID randomized controlled trial</title><author>Czech-Kowalska, Justyna ; Latka-Grot, Julita ; Bulsiewicz, Dorota ; Jaworski, Maciej ; Pludowski, Pawel ; Wygledowska, Grazyna ; Chazan, Bogdan ; Pawlus, Beata ; Zochowska, Anna ; Borszewska-Kornacka, Maria K ; Karczmarewicz, Elzbieta ; Czekuc-Kryskiewicz, Edyta ; Dobrzanska, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-7815c41e13a2c8f593f5eeeaf7f1c69e9281d54b5f8917fac25799d4bb07197f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adult</topic><topic>Babies</topic><topic>Biochemistry</topic><topic>Biology and Life Sciences</topic><topic>Birth Weight</topic><topic>Body Composition</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Bone composition</topic><topic>Bone Density</topic><topic>Bone mass</topic><topic>Breast Feeding</topic><topic>Breastfeeding & lactation</topic><topic>Calcium</topic><topic>Calcium (urinary)</topic><topic>Calcium - blood</topic><topic>Calciuria</topic><topic>Cholecalciferol - administration & dosage</topic><topic>Correlation analysis</topic><topic>Densitometers</topic><topic>Densitometry</topic><topic>Diabetes</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Drug dosages</topic><topic>Ethics</topic><topic>Families & family life</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Intensive care</topic><topic>Lactation</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Methyltestosterone</topic><topic>Mothers</topic><topic>Newborn babies</topic><topic>Nursing</topic><topic>Offspring</topic><topic>Parathyroid Hormone - blood</topic><topic>Physiological aspects</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Randomization</topic><topic>Supplements</topic><topic>Treatment Outcome</topic><topic>Vitamin D</topic><topic>Vitamin deficiency</topic><topic>Vitamins - administration & dosage</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Czech-Kowalska, Justyna</creatorcontrib><creatorcontrib>Latka-Grot, Julita</creatorcontrib><creatorcontrib>Bulsiewicz, Dorota</creatorcontrib><creatorcontrib>Jaworski, Maciej</creatorcontrib><creatorcontrib>Pludowski, Pawel</creatorcontrib><creatorcontrib>Wygledowska, Grazyna</creatorcontrib><creatorcontrib>Chazan, Bogdan</creatorcontrib><creatorcontrib>Pawlus, Beata</creatorcontrib><creatorcontrib>Zochowska, Anna</creatorcontrib><creatorcontrib>Borszewska-Kornacka, Maria K</creatorcontrib><creatorcontrib>Karczmarewicz, Elzbieta</creatorcontrib><creatorcontrib>Czekuc-Kryskiewicz, Edyta</creatorcontrib><creatorcontrib>Dobrzanska, Anna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Czech-Kowalska, Justyna</au><au>Latka-Grot, Julita</au><au>Bulsiewicz, Dorota</au><au>Jaworski, Maciej</au><au>Pludowski, Pawel</au><au>Wygledowska, Grazyna</au><au>Chazan, Bogdan</au><au>Pawlus, Beata</au><au>Zochowska, Anna</au><au>Borszewska-Kornacka, Maria K</au><au>Karczmarewicz, Elzbieta</au><au>Czekuc-Kryskiewicz, Edyta</au><au>Dobrzanska, Anna</au><au>Cameron, D. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of vitamin D supplementation during lactation on vitamin D status and body composition of mother-infant pairs: a MAVID randomized controlled trial</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-09-18</date><risdate>2014</risdate><volume>9</volume><issue>9</issue><spage>e107708</spage><epage>e107708</epage><pages>e107708-e107708</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The optimal vitamin D intake for nursing women is controversial. Deterioration, at least in bone mass, is reported during lactation. This study evaluated whether vitamin D supplementation during lactation enhances the maternal and infant's vitamin D status, bone mass and body composition.
After term delivery, 174 healthy mothers were randomized to receive 1200 IU/d (800 IU/d+400 IU/d from multivitamins) or 400 IU/d (placebo+400 IU/d from multivitamins) of cholecalciferol for 6 months while breastfeeding. All infants received 400 IU/d of cholecalciferol. Serum 25-hydroxyvitamin D [25(OH)D], iPTH, calcium, urinary calcium, and densitometry were performed in mother-offspring pairs after delivery, and at 3 and 6 months later.
A total of 137 (79%) (n = 70; 1200 IU/d, n = 67; 400 IU/d) completed the study. 25(OH)D was similar in both groups at baseline (13.7 ng/ml vs. 16.1 ng/ml; P = 0.09) and at 3 months (25.7 ng/ml vs. 24.5 ng/ml; P = 0.09), but appeared higher in the 1200 IU/d group at 6 months of supplementation (25.6 ng/ml vs. 23.1 ng/ml; P = 0.009). The prevalence of 25(OH)D <20 ng/ml was comparable between groups at baseline (71% vs. 64%, P = 0.36) but lower in the 1200 IU/d group after 3 months (9% vs. 25%, P = 0.009) and 6 months (14% vs. 30%, P = 0.03). Maternal and infants' iPTH, calciuria, bone mass and body composition as well as infants' 25(OH)D levels were not significantly different between groups during the study. Significant negative correlations were noted between maternal 25(OH)D and fat mass (R = -0.49, P = 0.00001), android fat mass (R = -0.53, P = 0.00001), and gynoid fat mass (R = -0.43, P = 0.00001) after 6 months of supplementation.
Vitamin D supplementation at a dose of 400 IU/d was not sufficient to maintain 25(OH)D >20 ng/ml in nursing women, while 1200 IU/d appeared more effective, but had no effect on breastfed offspring vitamin D status, or changes in the bone mass and the body composition observed in both during breastfeeding.
ClinicalTrials.gov NCT01506557.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25232839</pmid><doi>10.1371/journal.pone.0107708</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-09, Vol.9 (9), p.e107708-e107708 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1563048534 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 25-Hydroxyvitamin D Adult Babies Biochemistry Biology and Life Sciences Birth Weight Body Composition Body fat Body Mass Index Bone composition Bone Density Bone mass Breast Feeding Breastfeeding & lactation Calcium Calcium (urinary) Calcium - blood Calciuria Cholecalciferol - administration & dosage Correlation analysis Densitometers Densitometry Diabetes Dietary Supplements Double-Blind Method Drug dosages Ethics Families & family life Female Hospitals Humans Infant, Newborn Infants Intensive care Lactation Male Medicine Medicine and Health Sciences Metabolism Methyltestosterone Mothers Newborn babies Nursing Offspring Parathyroid Hormone - blood Physiological aspects Pregnancy Prospective Studies Randomization Supplements Treatment Outcome Vitamin D Vitamin deficiency Vitamins - administration & dosage Womens health |
| title | Impact of vitamin D supplementation during lactation on vitamin D status and body composition of mother-infant pairs: a MAVID randomized controlled trial |
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