Separation anxiety, attachment and inter-personal representations: disentangling the role of oxytocin in the perinatal period
In this paper, we aimed to assess cross-sectionally and longitudinally associations between disturbances in maternal early attachment experiences, symptoms of separation anxiety and depression and oxytocin plasma levels. We examined a mediational model that tested the hypothesis that anxious attachm...
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| Veröffentlicht in: | PloS one 2014-09, Vol.9 (9), p.e107745-e107745 |
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| creator | Eapen, Valsamma Dadds, Mark Barnett, Bryanne Kohlhoff, Jane Khan, Feroza Radom, Naomi Silove, Derrick M |
| description | In this paper, we aimed to assess cross-sectionally and longitudinally associations between disturbances in maternal early attachment experiences, symptoms of separation anxiety and depression and oxytocin plasma levels. We examined a mediational model that tested the hypothesis that anxious attachment style arising from the mothers' early bonding experiences with her own parents was associated with high levels of separation anxiety which, via its impact on depression, was associated with reduced levels of oxytocin in the postnatal period. Data is reported on a structured sample of 127 women recruited during pregnancy from a general hospital antenatal clinic and an initial follow up cohort of 57 women who were re-assessed at 3-months post-partum. We found an association between lower oxytocin level in the post partum period and symptoms of separation anxiety and depression during pregnancy, as well as maternal negative interpersonal representations, upbringing attributes and anxious attachment style. Further meditational analysis revealed that the unique association between anxious attachment and depression is mediated by separation anxiety and that depressed mood mediated the relationship between separation anxiety and oxytocin. In conjunction with evidence from the literature suggesting that lower oxytocin level is associated with bonding difficulties, our findings have significant implications for understanding the biological processes underpinning adverse attachment experiences, negative affect state, and mother-to-infant bonding difficulties. |
| doi_str_mv | 10.1371/journal.pone.0107745 |
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We examined a mediational model that tested the hypothesis that anxious attachment style arising from the mothers' early bonding experiences with her own parents was associated with high levels of separation anxiety which, via its impact on depression, was associated with reduced levels of oxytocin in the postnatal period. Data is reported on a structured sample of 127 women recruited during pregnancy from a general hospital antenatal clinic and an initial follow up cohort of 57 women who were re-assessed at 3-months post-partum. We found an association between lower oxytocin level in the post partum period and symptoms of separation anxiety and depression during pregnancy, as well as maternal negative interpersonal representations, upbringing attributes and anxious attachment style. Further meditational analysis revealed that the unique association between anxious attachment and depression is mediated by separation anxiety and that depressed mood mediated the relationship between separation anxiety and oxytocin. In conjunction with evidence from the literature suggesting that lower oxytocin level is associated with bonding difficulties, our findings have significant implications for understanding the biological processes underpinning adverse attachment experiences, negative affect state, and mother-to-infant bonding difficulties.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0107745</identifier><identifier>PMID: 25229827</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Analysis ; Anxiety ; Anxiety, Separation - blood ; Anxiety, Separation - psychology ; Attachment ; Babies ; Behavior ; Biological activity ; Biology and Life Sciences ; Bonding ; Brain research ; Child & adolescent psychiatry ; Child psychology ; Comorbidity ; Cross-Sectional Studies ; Depression (Mood disorder) ; Depression, Postpartum - psychology ; Emotions ; Epigenetics ; Female ; Females ; Gene expression ; Hormones ; Humans ; Infant ; Longitudinal Studies ; Medicine and Health Sciences ; Mental depression ; Mental health ; Middle Aged ; Models, Psychological ; Mood ; Mother-Child Relations - psychology ; Mothers ; Neurosciences ; Object Attachment ; Oxytocin ; Oxytocin - blood ; Parent-child relations ; Parents ; Parents & parenting ; Parents - psychology ; Pituitary hormones ; Plasma levels ; Postpartum depression ; Pregnancy ; Psychobiology ; Representations ; Rodents ; Separation ; Separation anxiety ; Studies ; Young Adult</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e107745-e107745</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Eapen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Further meditational analysis revealed that the unique association between anxious attachment and depression is mediated by separation anxiety and that depressed mood mediated the relationship between separation anxiety and oxytocin. 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We examined a mediational model that tested the hypothesis that anxious attachment style arising from the mothers' early bonding experiences with her own parents was associated with high levels of separation anxiety which, via its impact on depression, was associated with reduced levels of oxytocin in the postnatal period. Data is reported on a structured sample of 127 women recruited during pregnancy from a general hospital antenatal clinic and an initial follow up cohort of 57 women who were re-assessed at 3-months post-partum. We found an association between lower oxytocin level in the post partum period and symptoms of separation anxiety and depression during pregnancy, as well as maternal negative interpersonal representations, upbringing attributes and anxious attachment style. Further meditational analysis revealed that the unique association between anxious attachment and depression is mediated by separation anxiety and that depressed mood mediated the relationship between separation anxiety and oxytocin. In conjunction with evidence from the literature suggesting that lower oxytocin level is associated with bonding difficulties, our findings have significant implications for understanding the biological processes underpinning adverse attachment experiences, negative affect state, and mother-to-infant bonding difficulties.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25229827</pmid><doi>10.1371/journal.pone.0107745</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-09, Vol.9 (9), p.e107745-e107745 |
| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Analysis Anxiety Anxiety, Separation - blood Anxiety, Separation - psychology Attachment Babies Behavior Biological activity Biology and Life Sciences Bonding Brain research Child & adolescent psychiatry Child psychology Comorbidity Cross-Sectional Studies Depression (Mood disorder) Depression, Postpartum - psychology Emotions Epigenetics Female Females Gene expression Hormones Humans Infant Longitudinal Studies Medicine and Health Sciences Mental depression Mental health Middle Aged Models, Psychological Mood Mother-Child Relations - psychology Mothers Neurosciences Object Attachment Oxytocin Oxytocin - blood Parent-child relations Parents Parents & parenting Parents - psychology Pituitary hormones Plasma levels Postpartum depression Pregnancy Psychobiology Representations Rodents Separation Separation anxiety Studies Young Adult |
| title | Separation anxiety, attachment and inter-personal representations: disentangling the role of oxytocin in the perinatal period |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T01%3A23%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Separation%20anxiety,%20attachment%20and%20inter-personal%20representations:%20disentangling%20the%20role%20of%20oxytocin%20in%20the%20perinatal%20period&rft.jtitle=PloS%20one&rft.au=Eapen,%20Valsamma&rft.date=2014-09-17&rft.volume=9&rft.issue=9&rft.spage=e107745&rft.epage=e107745&rft.pages=e107745-e107745&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0107745&rft_dat=%3Cgale_plos_%3EA418424485%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1562653860&rft_id=info:pmid/25229827&rft_galeid=A418424485&rft_doaj_id=oai_doaj_org_article_2965f9f0caf24b1d98ae1330049e659c&rfr_iscdi=true |