Comparison of the structure and function of phospholamban and the arginine-14 deficient mutant associated with dilated cardiomyopathy

Phospholamban (PLB) is a pentameric protein that plays an important role in regulating cardiac contractility via a reversible inhibitory association with the sarcoplasmic reticulum Ca2+ATPase (SERCA), the enzyme responsible for maintaining correct calcium homeostasis. Here we study the functional an...

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Veröffentlicht in:	PloS one 2014, Vol.9 (9), p.e106746-e106746
Hauptverfasser:	Hughes, Eleri, Middleton, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine Biochemistry Biology and Life Sciences Ca2+-transporting ATPase Calcium Calcium homeostasis Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cardiac muscle Cardiomyopathy Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - metabolism Chemistry Cornea Cyclic AMP-Dependent Protein Kinases - metabolism Deficient mutant Dilated cardiomyopathy Enzyme Activation Enzymes Heart diseases Homeostasis Humans Kinases Lipid Bilayers - chemistry Lipid Bilayers - metabolism Lipid membranes Localization Medicine and Health Sciences Membranes Models, Molecular Muscle contraction Musculoskeletal system Mutation NMR Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Phospholamban Phospholipids Phosphorylation Physical Sciences Protein Interaction Domains and Motifs Protein kinase A Protein Multimerization Protein Structure, Secondary Proteins Rodents Sarcoplasmic reticulum Structure-Activity Relationship Structure-function relationships Studies Thermodynamics
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