Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells
Interleukin-37 (IL-37), a member of IL-1 family, is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. However, the expression and role of IL-37 in Graves' disease (GD) remains unknown. This study aims to measure the levels of serum and peripheral blood mono...
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| description | Interleukin-37 (IL-37), a member of IL-1 family, is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. However, the expression and role of IL-37 in Graves' disease (GD) remains unknown. This study aims to measure the levels of serum and peripheral blood mononuclear cells (PBMCs) IL-37 in patients with Graves' disease and to examine its association with disease activity. Furthermore, we investigate the effect of IL-37 on proinflammatory cytokines involved in the pathogenesis of GD.
The expressions of IL-37, TNF-α, IL-6, and IL-17 mRNA in peripheral blood mononuclear cells (PBMCs) of 40 patients with Graves' disease were determined by real-time reverse transcription-polymerase chain reaction (RT-PCR), and the levels of IL-37, TNF-α, IL-6, and IL-17 in serum were detected by enzyme-linked immunoassay (ELISA). The correlation of serum IL-37 levels with cytokines and disease activity in Graves' disease patients were investigated. The expressions of cytokines TNF-α, IL-6, and IL-17 in PBMCs under recombinant IL-37 stimulation were determined by RT-PCR and ELISA respectively.
The levels of IL-37, TNF-α, IL-6, and IL-17 in PBMCs and serum were significantly increased in patients with GD compared with healthy controls (HC). Serum IL-37 were closely correlated with TNF-α, IL-6, IL-17, thyrotropin (TSH), free thyroxine (FT4),free triiodothyronine (FT3) and thyrotropin receptor antibody (TRAB). GD patients with active disease showed higher IL-37 mRNA and serum protein levels compared with those with inactive disease as well as HC. Moreover, IL-37 suppressed the production of IL-6, IL-17 and TNF-α in PBMCs of patients with GD.
Increased level of IL-37 in patients with GD are associated with TNF-α, IL-6, IL-17 and disease activity, and it plays a protective role against inflammatory effect in GD by inhibiting the production of proinflammatory cytokines. Thus, IL-37 may provide a novel research target for the pathogenesis and therapy of GD. |
| doi_str_mv | 10.1371/journal.pone.0107183 |
| format | Article |
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The expressions of IL-37, TNF-α, IL-6, and IL-17 mRNA in peripheral blood mononuclear cells (PBMCs) of 40 patients with Graves' disease were determined by real-time reverse transcription-polymerase chain reaction (RT-PCR), and the levels of IL-37, TNF-α, IL-6, and IL-17 in serum were detected by enzyme-linked immunoassay (ELISA). The correlation of serum IL-37 levels with cytokines and disease activity in Graves' disease patients were investigated. The expressions of cytokines TNF-α, IL-6, and IL-17 in PBMCs under recombinant IL-37 stimulation were determined by RT-PCR and ELISA respectively.
The levels of IL-37, TNF-α, IL-6, and IL-17 in PBMCs and serum were significantly increased in patients with GD compared with healthy controls (HC). Serum IL-37 were closely correlated with TNF-α, IL-6, IL-17, thyrotropin (TSH), free thyroxine (FT4),free triiodothyronine (FT3) and thyrotropin receptor antibody (TRAB). GD patients with active disease showed higher IL-37 mRNA and serum protein levels compared with those with inactive disease as well as HC. Moreover, IL-37 suppressed the production of IL-6, IL-17 and TNF-α in PBMCs of patients with GD.
Increased level of IL-37 in patients with GD are associated with TNF-α, IL-6, IL-17 and disease activity, and it plays a protective role against inflammatory effect in GD by inhibiting the production of proinflammatory cytokines. Thus, IL-37 may provide a novel research target for the pathogenesis and therapy of GD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0107183</identifier><identifier>PMID: 25226272</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Biology ; Biology and Life Sciences ; Blood ; Case-Control Studies ; Cytokines ; Cytokines - blood ; Cytokines - genetics ; Cytokines - metabolism ; Disease ; Endocrinology ; Enzyme-linked immunosorbent assay ; Female ; Gene Expression ; Gene Expression Regulation ; Graves Disease - diagnosis ; Graves Disease - genetics ; Graves Disease - metabolism ; Graves' disease ; Humans ; Hyperthyroidism ; Immunoassay ; Immunology ; Immunotherapy ; Inflammation ; Inflammation Mediators - metabolism ; Interleukin 1 ; Interleukin 17 ; Interleukin 6 ; Interleukin-1 - blood ; Interleukin-1 - genetics ; Interleukin-1 - metabolism ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - metabolism ; Lupus ; Male ; Medical research ; Medicine ; Middle Aged ; Pathogenesis ; Pathogens ; Patients ; Peripheral blood mononuclear cells ; Polymerase chain reaction ; Psoriasis ; Reverse transcription ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; Studies ; Thyroid gland ; Thyroid hormones ; Thyroid-stimulating hormone ; Thyroxine ; TNF inhibitors ; Triiodothyronine ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Weight control ; Young Adult</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e107183-e107183</ispartof><rights>2014 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Li et al 2014 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-8d1ac82d030d4d0ef7c9159491552f4076e556e4020bfe63040eab33317a01dd3</citedby><cites>FETCH-LOGICAL-c526t-8d1ac82d030d4d0ef7c9159491552f4076e556e4020bfe63040eab33317a01dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165889/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165889/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25226272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yanqun</creatorcontrib><creatorcontrib>Wang, Zi</creatorcontrib><creatorcontrib>Yu, Ting</creatorcontrib><creatorcontrib>Chen, Bingni</creatorcontrib><creatorcontrib>Zhang, Jinshun</creatorcontrib><creatorcontrib>Huang, Kunzhao</creatorcontrib><creatorcontrib>Huang, Zhong</creatorcontrib><title>Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Interleukin-37 (IL-37), a member of IL-1 family, is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. However, the expression and role of IL-37 in Graves' disease (GD) remains unknown. This study aims to measure the levels of serum and peripheral blood mononuclear cells (PBMCs) IL-37 in patients with Graves' disease and to examine its association with disease activity. Furthermore, we investigate the effect of IL-37 on proinflammatory cytokines involved in the pathogenesis of GD.
The expressions of IL-37, TNF-α, IL-6, and IL-17 mRNA in peripheral blood mononuclear cells (PBMCs) of 40 patients with Graves' disease were determined by real-time reverse transcription-polymerase chain reaction (RT-PCR), and the levels of IL-37, TNF-α, IL-6, and IL-17 in serum were detected by enzyme-linked immunoassay (ELISA). The correlation of serum IL-37 levels with cytokines and disease activity in Graves' disease patients were investigated. The expressions of cytokines TNF-α, IL-6, and IL-17 in PBMCs under recombinant IL-37 stimulation were determined by RT-PCR and ELISA respectively.
The levels of IL-37, TNF-α, IL-6, and IL-17 in PBMCs and serum were significantly increased in patients with GD compared with healthy controls (HC). Serum IL-37 were closely correlated with TNF-α, IL-6, IL-17, thyrotropin (TSH), free thyroxine (FT4),free triiodothyronine (FT3) and thyrotropin receptor antibody (TRAB). GD patients with active disease showed higher IL-37 mRNA and serum protein levels compared with those with inactive disease as well as HC. Moreover, IL-37 suppressed the production of IL-6, IL-17 and TNF-α in PBMCs of patients with GD.
Increased level of IL-37 in patients with GD are associated with TNF-α, IL-6, IL-17 and disease activity, and it plays a protective role against inflammatory effect in GD by inhibiting the production of proinflammatory cytokines. Thus, IL-37 may provide a novel research target for the pathogenesis and therapy of GD.</description><subject>Adult</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Case-Control Studies</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Disease</subject><subject>Endocrinology</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Expression Regulation</subject><subject>Graves Disease - diagnosis</subject><subject>Graves Disease - genetics</subject><subject>Graves Disease - metabolism</subject><subject>Graves' disease</subject><subject>Humans</subject><subject>Hyperthyroidism</subject><subject>Immunoassay</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukin 1</subject><subject>Interleukin 17</subject><subject>Interleukin 6</subject><subject>Interleukin-1 - blood</subject><subject>Interleukin-1 - genetics</subject><subject>Interleukin-1 - metabolism</subject><subject>Leukocytes (mononuclear)</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Lupus</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Peripheral blood mononuclear cells</subject><subject>Polymerase chain reaction</subject><subject>Psoriasis</subject><subject>Reverse transcription</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>Studies</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroxine</subject><subject>TNF inhibitors</subject><subject>Triiodothyronine</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Weight control</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk2P0zAUjBCIXQr_AIElDnBp8UfsJBcktIKlUiUucLYc-2XrktjBdhb6r_iJOG131UVcbMtvZt680SuKlwSvCKvI-52fglP9avQOVpjgitTsUXFJGkaXgmL2-Ox9UTyLcYcxZ7UQT4sLyikVtKKXxZ-10wFUBIPg9xggRusd8h1ab5asQtahUSULLkX0y6Ytug7qFuJbZGycWUg5g2wuau9SsO2UZnryKE7judoYvHVdr4ZBJR_2SO-T_2EdxLliJn2gzc0g2HELQfWo7b03aPDOu0n3oALS0PfxefGkU32EF6d7UXz__Onb1Zfl5uv1-urjZqk5FWlZG6J0TQ1m2JQGQ1fphvCmzAenXYkrAZwLKDHFbQeC4RKDahljpFKYGMMWxeuj7tj7KE9hR0m4oCWlvKIZsT4ijFc7OQY7qLCXXll5-PDhRqqQbPYu25bUmtCywlxnC2XdKiq4YlXVdAZ3PGt9OHWb2gGMzoHnDB6IPqw4u5U3_laWRPC6brLAu5NA8D8niEkONs6BKQd-OvhmmDdNnnBRvPkH-v_pyiNKBx9jgO7eDMFyXsA7lpwXUJ4WMNNenQ9yT7rbOPYX1jndJw</recordid><startdate>20140916</startdate><enddate>20140916</enddate><creator>Li, Yanqun</creator><creator>Wang, Zi</creator><creator>Yu, Ting</creator><creator>Chen, Bingni</creator><creator>Zhang, Jinshun</creator><creator>Huang, Kunzhao</creator><creator>Huang, Zhong</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140916</creationdate><title>Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells</title><author>Li, Yanqun ; Wang, Zi ; Yu, Ting ; Chen, Bingni ; Zhang, Jinshun ; Huang, Kunzhao ; Huang, Zhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-8d1ac82d030d4d0ef7c9159491552f4076e556e4020bfe63040eab33317a01dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Case-Control Studies</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Disease</topic><topic>Endocrinology</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Expression Regulation</topic><topic>Graves Disease - diagnosis</topic><topic>Graves Disease - genetics</topic><topic>Graves Disease - metabolism</topic><topic>Graves' disease</topic><topic>Humans</topic><topic>Hyperthyroidism</topic><topic>Immunoassay</topic><topic>Immunology</topic><topic>Immunotherapy</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukin 1</topic><topic>Interleukin 17</topic><topic>Interleukin 6</topic><topic>Interleukin-1 - blood</topic><topic>Interleukin-1 - genetics</topic><topic>Interleukin-1 - metabolism</topic><topic>Leukocytes (mononuclear)</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lupus</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Pathogens</topic><topic>Patients</topic><topic>Peripheral blood mononuclear cells</topic><topic>Polymerase chain reaction</topic><topic>Psoriasis</topic><topic>Reverse transcription</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>Studies</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroxine</topic><topic>TNF inhibitors</topic><topic>Triiodothyronine</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Weight control</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yanqun</creatorcontrib><creatorcontrib>Wang, Zi</creatorcontrib><creatorcontrib>Yu, Ting</creatorcontrib><creatorcontrib>Chen, Bingni</creatorcontrib><creatorcontrib>Zhang, Jinshun</creatorcontrib><creatorcontrib>Huang, Kunzhao</creatorcontrib><creatorcontrib>Huang, Zhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yanqun</au><au>Wang, Zi</au><au>Yu, Ting</au><au>Chen, Bingni</au><au>Zhang, Jinshun</au><au>Huang, Kunzhao</au><au>Huang, Zhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-09-16</date><risdate>2014</risdate><volume>9</volume><issue>9</issue><spage>e107183</spage><epage>e107183</epage><pages>e107183-e107183</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Interleukin-37 (IL-37), a member of IL-1 family, is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. However, the expression and role of IL-37 in Graves' disease (GD) remains unknown. This study aims to measure the levels of serum and peripheral blood mononuclear cells (PBMCs) IL-37 in patients with Graves' disease and to examine its association with disease activity. Furthermore, we investigate the effect of IL-37 on proinflammatory cytokines involved in the pathogenesis of GD.
The expressions of IL-37, TNF-α, IL-6, and IL-17 mRNA in peripheral blood mononuclear cells (PBMCs) of 40 patients with Graves' disease were determined by real-time reverse transcription-polymerase chain reaction (RT-PCR), and the levels of IL-37, TNF-α, IL-6, and IL-17 in serum were detected by enzyme-linked immunoassay (ELISA). The correlation of serum IL-37 levels with cytokines and disease activity in Graves' disease patients were investigated. The expressions of cytokines TNF-α, IL-6, and IL-17 in PBMCs under recombinant IL-37 stimulation were determined by RT-PCR and ELISA respectively.
The levels of IL-37, TNF-α, IL-6, and IL-17 in PBMCs and serum were significantly increased in patients with GD compared with healthy controls (HC). Serum IL-37 were closely correlated with TNF-α, IL-6, IL-17, thyrotropin (TSH), free thyroxine (FT4),free triiodothyronine (FT3) and thyrotropin receptor antibody (TRAB). GD patients with active disease showed higher IL-37 mRNA and serum protein levels compared with those with inactive disease as well as HC. Moreover, IL-37 suppressed the production of IL-6, IL-17 and TNF-α in PBMCs of patients with GD.
Increased level of IL-37 in patients with GD are associated with TNF-α, IL-6, IL-17 and disease activity, and it plays a protective role against inflammatory effect in GD by inhibiting the production of proinflammatory cytokines. Thus, IL-37 may provide a novel research target for the pathogenesis and therapy of GD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25226272</pmid><doi>10.1371/journal.pone.0107183</doi><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1562422572 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Biology Biology and Life Sciences Blood Case-Control Studies Cytokines Cytokines - blood Cytokines - genetics Cytokines - metabolism Disease Endocrinology Enzyme-linked immunosorbent assay Female Gene Expression Gene Expression Regulation Graves Disease - diagnosis Graves Disease - genetics Graves Disease - metabolism Graves' disease Humans Hyperthyroidism Immunoassay Immunology Immunotherapy Inflammation Inflammation Mediators - metabolism Interleukin 1 Interleukin 17 Interleukin 6 Interleukin-1 - blood Interleukin-1 - genetics Interleukin-1 - metabolism Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Lupus Male Medical research Medicine Middle Aged Pathogenesis Pathogens Patients Peripheral blood mononuclear cells Polymerase chain reaction Psoriasis Reverse transcription RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Studies Thyroid gland Thyroid hormones Thyroid-stimulating hormone Thyroxine TNF inhibitors Triiodothyronine Tumor necrosis factor-TNF Tumor necrosis factor-α Weight control Young Adult |
| title | Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T23%3A36%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20expression%20of%20IL-37%20in%20patients%20with%20Graves'%20disease%20and%20its%20contribution%20to%20suppression%20of%20proinflammatory%20cytokines%20production%20in%20peripheral%20blood%20mononuclear%20cells&rft.jtitle=PloS%20one&rft.au=Li,%20Yanqun&rft.date=2014-09-16&rft.volume=9&rft.issue=9&rft.spage=e107183&rft.epage=e107183&rft.pages=e107183-e107183&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0107183&rft_dat=%3Cproquest_plos_%3E1563059933%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1562422572&rft_id=info:pmid/25226272&rft_doaj_id=oai_doaj_org_article_bb18c124705c49148ba265a3779fd0f5&rfr_iscdi=true |