Aberrant upregulation of 14-3-3σ and EZH2 expression serves as an inferior prognostic biomarker for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world. It is of important significance to find biomarkers for the prognostic monitoring of HCC. The 14-3-3σ and EZH2 proteins are involved in cell cycle regulation and epigenetic silencing. We herein examined the significance...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e107251-e107251
Hauptverfasser:	Zhang, Yi, Li, Yang, Lin, Changwei, Ding, Jie, Liao, Guoqing, Tang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein 14-3-3 Proteins - genetics Aberration Adult Aged Bioindicators Biology and Life Sciences Biomarkers Breast cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell cycle Correlation Deoxyribonucleic acid DNA DNA methylation Enhancer of Zeste Homolog 2 Protein Ethanol Female Gastrointestinal surgery Gene expression Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Humans Immunohistochemistry Kinases Liver - metabolism Liver cancer Liver cirrhosis Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - pathology Male Malignancy Medical diagnosis Medical prognosis Medicine and Health Sciences Metastasis Middle Aged Neoplasm Grading Neoplasm Staging Patients Polycomb Repressive Complex 2 - genetics Polymerase chain reaction Prognosis Proteins ROC Curve Signal transduction Tumor Burden Tumors Up-Regulation
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