Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia

Diet-induced hyperhomocysteinemia produces endothelial and cardiac dysfunction and promotes thrombosis through a mechanism proposed to involve oxidative stress. Inducible nitric oxide synthase (iNOS) is upregulated in hyperhomocysteinemia and can generate superoxide. We therefore tested the hypothes...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e107734-e107734
Hauptverfasser:	Dayal, Sanjana, Blokhin, Ilya O, Erger, Rochelle A, Jensen, Melissa, Arning, Erland, Stevens, Jeff W, Bottiglieri, Teodoro, Faraci, Frank M, Lentz, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Animals Arterioles Atherosclerosis Bioavailability Biology and Life Sciences Cardiovascular disease Carotid arteries Carotid artery Cerebral Arteries - drug effects Cerebral Arteries - metabolism Cerebral blood flow Diet Disease Models, Animal Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Female Folic acid Gene expression Heart diseases Homocysteine Homocysteine - blood Hyperhomocysteinemia Hyperhomocysteinemia - genetics Hyperhomocysteinemia - metabolism Hypotheses Internal medicine Ischemia Laboratory animals Male Medicine Medicine and Health Sciences Metabolic disorders Methionine Methionine - blood Mice Mice, Knockout Myocardial infarction Myocardial ischemia Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardium - metabolism Nitric oxide Nitric Oxide Synthase Type II - deficiency Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Occlusion Oxidative stress Phenotype Photochemicals Reactive Oxygen Species - metabolism Reperfusion Rodents Smooth muscle Studies Superoxide Thromboembolism Thrombosis Thrombosis - metabolism Vasodilator Agents - pharmacology Veins & arteries
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