Structural basis for substrate specificity of mammalian neuraminidases

The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes. The enzymes play distinct physiological roles, but their ability to discriminate between the types of linkages connect...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e106320-e106320
Hauptverfasser:	Smutova, Victoria, Albohy, Amgad, Pan, Xuefang, Korchagina, Elena, Miyagi, Taeko, Bovin, Nicolai, Cairo, Christopher W, Pshezhetsky, Alexey V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antigens Binding Sites Biology and Life Sciences Brain Brain - enzymology Cancer Chemistry Cloning D-Galactose Enzymes Galactose Genetics Glucosamine Glycoconjugates Heparan sulfate Hydrolysis Hydrophobicity Kinetics Localization Mammals Medicine and Health Sciences Membranes Mice, Knockout Models, Molecular Molecular dynamics Musculoskeletal system N-Acetylglucosamine N-Acetylneuraminic Acid - chemistry N-Acetylneuraminic Acid - metabolism Neuraminidase - chemistry Oligosaccharides Plasma Protein Structure, Tertiary Proteins Residues Substrate preferences Substrate Specificity Substrates Sugar Tissues Vertebrates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!