Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study

Self-assembly of the intrinsically unstructured proteins, amyloid beta (Aβ) and alpha synclein (αSyn), are associated with Alzheimer's Disease, and Parkinson's and Lewy Body Diseases, respectively. Importantly, pathological overlaps between these neurodegenerative diseases, and the possibi...

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Veröffentlicht in:	PloS one 2014, Vol.9 (9), p.e106883-e106883
Hauptverfasser:	Jose, Jaya C, Chatterjee, Prathit, Sengupta, Neelanjana
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - genetics alpha-Synuclein - metabolism Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Biology and Life Sciences Computer and Information Sciences Dimerization Electrostatic properties Entropy Humans Hydrophobic and Hydrophilic Interactions Hydrophobicity Laboratories Lewy bodies Molecular chains Molecular dynamics Molecular Dynamics Simulation Neurodegeneration Neurodegenerative diseases Neurological diseases Neurosciences Peptides Physical chemistry Principal Component Analysis Principal components analysis Protein Interaction Maps Proteins Self-assembly Studies Water - chemistry
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