Synergistic combination of gemcitabine and dietary molecule induces apoptosis in pancreatic cancer cells and down regulates PKM2 expression

Gemcitabine, an effective agent in treatment of cancer of pancreas, has undergone failures in many instances after multiple cycles of therapy due to emergence of drug resistance. Combination of dietary compounds with clinically validated drugs has emerged as an effective therapeutic approach to trea...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e107154
Hauptverfasser:	Pandita, Archana, Kumar, Bhupender, Manvati, Siddharth, Vaishnavi, Samantha, Singh, Shashank K, Bamezai, Rameshwar N K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antagonism Antimetabolites, Antineoplastic - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Benzoquinones - pharmacology Betulinic Acid Biotechnology Cancer Cancer therapies Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Cell division Cell proliferation Cell Proliferation - drug effects Colorectal cancer Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Diet Drug dosages Drug resistance Drug Synergism Enzymes Flow Cytometry Gemcitabine Gene Expression Regulation, Neoplastic - drug effects Humans Immunoblotting Kinases Leukemia Life sciences Medicine and Health Sciences Membrane Potential, Mitochondrial - drug effects Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Metabolism Mitochondria Nigella sativa Oils & fats Pancreas Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pentacyclic Triterpenes Permeability Pyruvate kinase Pyruvic acid Synergism Therapy Thyroid Hormone-Binding Proteins Thyroid Hormones - metabolism Triterpenes - pharmacology Tumor cell lines Tumor Cells, Cultured Tumors
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