Quantifying the reconfiguration of intrinsic networks during working memory
Rapid, flexible reconfiguration of connections across brain regions is thought to underlie successful cognitive control. Two intrinsic networks in particular, the cingulo-opercular (CO) and fronto-parietal (FP), are thought to underlie two operations critical for cognitive control: task-set maintena...
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| Veröffentlicht in: | PloS one 2014-09, Vol.9 (9), p.e106636-e106636 |
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| creator | Cohen, Jessica R Gallen, Courtney L Jacobs, Emily G Lee, Taraz G D'Esposito, Mark |
| description | Rapid, flexible reconfiguration of connections across brain regions is thought to underlie successful cognitive control. Two intrinsic networks in particular, the cingulo-opercular (CO) and fronto-parietal (FP), are thought to underlie two operations critical for cognitive control: task-set maintenance/tonic alertness and adaptive, trial-by-trial updating. Using functional magnetic resonance imaging, we directly tested whether the functional connectivity of the CO and FP networks was related to cognitive demands and behavior. We focused on working memory because of evidence that during working memory tasks the entire brain becomes more integrated. When specifically probing the CO and FP cognitive control networks, we found that individual regions of both intrinsic networks were active during working memory and, as expected, integration across the two networks increased during task blocks that required cognitive control. Crucially, increased integration between each of the cognitive control networks and a task-related, non-cognitive control network (the hand somatosensory-motor network; SM) was related to increased accuracy. This implies that dynamic reconfiguration of the CO and FP networks so as to increase their inter-network communication underlies successful working memory. |
| doi_str_mv | 10.1371/journal.pone.0106636 |
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Two intrinsic networks in particular, the cingulo-opercular (CO) and fronto-parietal (FP), are thought to underlie two operations critical for cognitive control: task-set maintenance/tonic alertness and adaptive, trial-by-trial updating. Using functional magnetic resonance imaging, we directly tested whether the functional connectivity of the CO and FP networks was related to cognitive demands and behavior. We focused on working memory because of evidence that during working memory tasks the entire brain becomes more integrated. When specifically probing the CO and FP cognitive control networks, we found that individual regions of both intrinsic networks were active during working memory and, as expected, integration across the two networks increased during task blocks that required cognitive control. Crucially, increased integration between each of the cognitive control networks and a task-related, non-cognitive control network (the hand somatosensory-motor network; SM) was related to increased accuracy. This implies that dynamic reconfiguration of the CO and FP networks so as to increase their inter-network communication underlies successful working memory.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0106636</identifier><identifier>PMID: 25191704</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptive control ; Adolescent ; Adult ; Alertness ; Biology and Life Sciences ; Brain ; Brain - physiology ; Brain Mapping ; Cognition & reasoning ; Cognitive ability ; Female ; Functional magnetic resonance imaging ; Humans ; Integration ; Magnetic resonance ; Magnetic resonance imaging ; Male ; Memory ; Memory tasks ; Memory, Short-Term ; Mental task performance ; Nerve Net ; Networks ; Neural networks ; Neuroimaging ; Neurosciences ; Photic Stimulation ; Reconfiguration ; Research and Analysis Methods ; Short term memory ; Studies ; Womens health ; Young Adult</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e106636-e106636</ispartof><rights>2014 Cohen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Crucially, increased integration between each of the cognitive control networks and a task-related, non-cognitive control network (the hand somatosensory-motor network; SM) was related to increased accuracy. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, Jessica R</au><au>Gallen, Courtney L</au><au>Jacobs, Emily G</au><au>Lee, Taraz G</au><au>D'Esposito, Mark</au><au>Stamatakis, Emmanuel Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantifying the reconfiguration of intrinsic networks during working memory</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-09-05</date><risdate>2014</risdate><volume>9</volume><issue>9</issue><spage>e106636</spage><epage>e106636</epage><pages>e106636-e106636</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Rapid, flexible reconfiguration of connections across brain regions is thought to underlie successful cognitive control. Two intrinsic networks in particular, the cingulo-opercular (CO) and fronto-parietal (FP), are thought to underlie two operations critical for cognitive control: task-set maintenance/tonic alertness and adaptive, trial-by-trial updating. Using functional magnetic resonance imaging, we directly tested whether the functional connectivity of the CO and FP networks was related to cognitive demands and behavior. We focused on working memory because of evidence that during working memory tasks the entire brain becomes more integrated. When specifically probing the CO and FP cognitive control networks, we found that individual regions of both intrinsic networks were active during working memory and, as expected, integration across the two networks increased during task blocks that required cognitive control. Crucially, increased integration between each of the cognitive control networks and a task-related, non-cognitive control network (the hand somatosensory-motor network; SM) was related to increased accuracy. This implies that dynamic reconfiguration of the CO and FP networks so as to increase their inter-network communication underlies successful working memory.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25191704</pmid><doi>10.1371/journal.pone.0106636</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptive control Adolescent Adult Alertness Biology and Life Sciences Brain Brain - physiology Brain Mapping Cognition & reasoning Cognitive ability Female Functional magnetic resonance imaging Humans Integration Magnetic resonance Magnetic resonance imaging Male Memory Memory tasks Memory, Short-Term Mental task performance Nerve Net Networks Neural networks Neuroimaging Neurosciences Photic Stimulation Reconfiguration Research and Analysis Methods Short term memory Studies Womens health Young Adult |
| title | Quantifying the reconfiguration of intrinsic networks during working memory |
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