LIN28A expression reduces sickling of cultured human erythrocytes

Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with sickle cell disease (SCD) and the beta-thalassemias. It was recently reported that increased expression of LIN28 proteins or decreased expression of its target let-7 miRNAs enhances HbF levels in cultured primary human...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e106924-e106924
Hauptverfasser:	de Vasconcellos, Jaira F, Fasano, Ross M, Lee, Y Terry, Kaushal, Megha, Byrnes, Colleen, Meier, Emily R, Anderson, Molly, Rabel, Antoinette, Braylan, Raul, Stroncek, David F, Miller, Jeffery L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Anemia, Sickle Cell - genetics Anemia, Sickle Cell - metabolism Anemia, Sickle Cell - pathology Anemia, Sickle Cell - therapy beta-Globins - genetics beta-Globins - metabolism Biology and Life Sciences Blood diseases Cancer CD34 antigen Cell Differentiation Cell Shape Cells (biology) Child Children & youth Diabetes Enucleation Erythroblasts Erythroblasts - metabolism Erythroblasts - pathology Erythrocyte Transfusion Erythrocytes Erythrocytes, Abnormal - metabolism Erythrocytes, Abnormal - pathology Fetal Hemoglobin - genetics Fetal Hemoglobin - metabolism Fetuses Gene expression Gene Expression Regulation Genetic engineering Genetic Vectors Genomes Genomics Health aspects Hemoglobin Hemoglobins Hemopoiesis Humans Kidney diseases Lentivirus - genetics Lentivirus - metabolism Male Medicine Medicine and Health Sciences MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Overexpression Peripheral blood Polymerization Primary Cell Culture Proteins RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Serum-free medium Sickle cell anemia Sickle cell disease Signal Transduction Studies Transfection Transgenic
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